Patents by Inventor Noel P. Bouck
Noel P. Bouck has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 7723313Abstract: The present invention provides a method of inhibiting angiogenesis within a tissue by providing exogenous PEDF to cells associated with the tissue. The presence of exogenous PEDF inhibits angiogenesis within the tissue, in part by interfering with the ability of vascular endothelia to expand within the tissue. The invention also provides a method for determining the severity of a tumor be assaying for the presence of PEDF within the tumor. To facilitate the inventive methods, the present invention provides pharmaceutical compositions including sources of PEDF.Type: GrantFiled: July 26, 2006Date of Patent: May 25, 2010Assignee: Northwestern UniversityInventors: Noel P. Bouck, David W. Dawson, Paul R. Gillis, Olga Volpert, Susan E. Crawford, Veronica M. Stellmach
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Patent number: 7105496Abstract: The present invention provides a method of inhibiting angiogenesis within a tissue by providing exogenous PEDF to cells associated with the tissue. The presence of exogenous PEDF inhibits angiogenesis within the tissue, in part by interfering with the ability of vascular endothelia to expand within the tissue. The invention also provides a method for determining the severity of a tumor be assaying for the presence of PEDF within the tumor. To facilitate the inventive methods, the present invention provides pharmaceutical compositions including sources of PEDF.Type: GrantFiled: June 25, 2003Date of Patent: September 12, 2006Assignee: Northwestern UniversityInventors: Noël P. Bouck, David W. Dawson, Paul R. Gillis, Olga Volpert, Susan E. Crawford, Veronica M. Stellmach
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Patent number: 6919309Abstract: The present invention provides a method of inhibiting angiogenesis within a tissue by providing exogenous PEDF to cells associated with the tissue. The presence of exogenous PEDF inhibits angiogenesis within the tissue, in part by interfering with the ability of vascular endothelia to expand within the tissue. The invention also provides a method for determining the severity of a tumor by assaying for the presence of PEDF within the tumor. The invention further provides a method of inhibiting endothelial cell migration, a method of stimulating the growth of hair in a mammal, a method for inhibiting the growth of a tumor, a method of inducing differentiation of a neuroblastoma cell, a method of slowing the growth of a neuroblastoma cell, and method of treating ischemic retinopathy in a mammal. To facilitate the inventive methods, the present invention provides pharmaceutical compositions including sources of PEDF.Type: GrantFiled: January 14, 2003Date of Patent: July 19, 2005Assignee: Northwestern UniversityInventors: Noël P. Bouck, David W. Dawson, Paul R. Gillis, Olga Volpert, Susan E. Crawford, Veronica M. Stellmach
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Patent number: 6797691Abstract: The present invention provides a method of inhibiting angiogenesis within a tissue by providing exogenous PEDF to cells associated with the tissue. The presence of exogenous PEDF inhibits angiogenesis within the tissue, in part by interfering with the ability of vascular endothelia to expand within the tissue. The invention also provides a method for determining the severity of a tumor by assaying for the presence of PEDF within the tumor. The invention further provides a method of inhibiting endothelial cell migration, a method of stimulating the growth of hair in a mammal, a method for inhibiting the growth of a tumor, a method of inducing differentiation of a neuroblastoma cell, a method of slowing the growth of a neuroblastoma cell, and method of treating ischemic retinopathy in a mammal. To facilitate the inventive methods, the present invention provides pharmaceutical compositions including sources of PEDF.Type: GrantFiled: June 23, 2000Date of Patent: September 28, 2004Assignee: Northwestern UniversityInventors: Noël P. Bouck, David W. Dawson, Paul R. Gillis, Olga Volpert, Susan E. Crawford, Veronica M. Stellmach
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Publication number: 20040014664Abstract: The present invention provides a method of inhibiting angiogenesis within a tissue by providing exogenous PEDF to cells associated with the tissue. The presence of exogenous PEDF inhibits angiogenesis within the tissue, in part by interfering with the ability of vascular endothelia to expand within the tissue. The invention also provides a method for determining the severity of a tumor be assaying for the presence of PEDF within the tumor. To facilitate the inventive methods, the present invention provides pharmaceutical compositions including sources of PEDF.Type: ApplicationFiled: June 25, 2003Publication date: January 22, 2004Applicant: NORTHWESTERN UNIVERSITYInventors: Noel P. Bouck, David W. Dawson, Paul R. Gillis, Olga Volpert, Susan E. Crawford, Veronica M. Stellmach
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Publication number: 20040003423Abstract: The present invention relates to transgenic knockout animal models null for pigment epithelium-derived factor (PEDF). The present invention also provides methods for generating animal disease models and screening methods for identifying biologically active compounds.Type: ApplicationFiled: February 10, 2003Publication date: January 1, 2004Applicant: Northwestern UniversityInventors: Noel P. Bouck, Susan E. Crawford, Veronica Stellmach
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Patent number: 6670333Abstract: The present invention provides a method of inhibiting angiogenesis within a tissue by providing exogenous SLED to cells associated with the tissue. The presence of exogenous SLED inhibits angiogenesis within the tissue, in part by interfering with the ability of vascular endothelia to expand within the tissue. The invention also provides a method for determining the severity of a tumor be assaying for the presence of SLED within the tumor. To facilitate the inventive methods, the present invention provides pharmaceutical compositions including sources of SLED.Type: GrantFiled: June 6, 2001Date of Patent: December 30, 2003Assignee: Northwestern UniversityInventors: Noel P. Bouck, David W. Dawson, Paul R. Gillis
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Publication number: 20030216286Abstract: The present invention provides a method of inhibiting angiogenesis within a tissue by providing exogenous PEDF to cells associated with the tissue. The presence of exogenous PEDF inhibits angiogenesis within the tissue, in part by interfering with the ability of vascular endothelia to expand within the tissue. The invention also provides a method for determining the severity of a tumor by assaying for the presence of PEDF within the tumor. The invention further provides a method of inhibiting endothelial cell migration, a method of stimulating the growth of hair in a mammal, a method for inhibiting the growth of a tumor, a method of inducing differentiation of a neuroblastoma cell, a method of slowing the growth of a neuroblastoma cell, and method of treating ischemic retinopathy in a mammal. To facilitate the inventive methods, the present invention provides pharmaceutical compositions including sources of PEDF.Type: ApplicationFiled: January 14, 2003Publication date: November 20, 2003Applicant: NORTHWESTERN UNIVERSITYInventors: Noel P. Bouck, David W. Dawson, Paul R. Gillis, Olga Volpert, Susan E. Crawford, Veronica M. Stellmach
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Patent number: 6391850Abstract: The present invention provides a method of inhibiting angiogenesis within a tissue by providing exogenous SLED to cells associated with the tissue. The presence of exogenous SLED inhibits angiogenesis within the tissue, in part by interfering with the ability of vascular endothelia to expand within the tissue. The invention also provides a method for determining the severity of a tumor be assaying for the presence of SLED within the tumor. To facilitate the inventive methods, the present invention provides pharmaceutical compositions including sources of SLED.Type: GrantFiled: June 6, 2001Date of Patent: May 21, 2002Assignee: Northwestern UniversityInventors: Noel P. Bouck, David W. Dawson, Paul R. Gillis
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Publication number: 20020002131Abstract: The present invention provides a method of inhibiting angiogenesis within a tissue by providing exogenous SLED to cells associated with the tissue. The presence of exogenous SLED inhibits angiogenesis within the tissue, in part by interfering with the ability of vascular endothelia to expand within the tissue. The invention also provides a method for determining the severity of a tumor be assaying for the presence of SLED within the tumor. To facilitate the inventive methods, the present invention provides pharmaceutical compositions including sources of SLED.Type: ApplicationFiled: June 6, 2001Publication date: January 3, 2002Inventors: Noel P. Bouck, David W. Dawson, Paul R. Gillis
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Publication number: 20010049355Abstract: The present invention provides a method of inhibiting angiogenesis within a tissue by providing exogenous SLED to cells associated with the tissue. The presence of exogenous SLED inhibits angiogenesis within the tissue, in part by interfering with the ability of vascular endothelia to expand within the tissue. The invention also provides a method for determining the severity of a tumor be assaying for the presence of SLED within the tumor. To facilitate the inventive methods, the present invention provides pharmaceutical compositions including sources of SLED.Type: ApplicationFiled: June 6, 2001Publication date: December 6, 2001Inventors: Noel P. Bouck, David W. Dawson, Paul R. Gillis
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Patent number: 6288024Abstract: The present invention provides a method of inhibiting angiogenesis within a tissue by providing exogenous SLED to cells associated with the tissue. The presence of exogenous SLED inhibits angiogenesis within the tissue, in part by interfering with the ability of vascular endothelia to expand within the tissue. The invention also provides a method for determining the severity of a tumor be assaying for the presence of SLED within the tumor. To facilitate the inventive methods, the present invention provides pharmaceutical compositions including sources of SLED.Type: GrantFiled: July 23, 1998Date of Patent: September 11, 2001Assignee: Northwestern UniversityInventors: Noel P. Bouck, David W. Dawson, Paul R. Gillis
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Patent number: 5932545Abstract: Peptides having the formula:T-Gly-Val-D-Ile-Thr-Arg-Ile-U,V-Gly-D-Val-Ile-D-Thr-D-Arg-D-Ile-W,X-D-Arg-D-Ile-D-Arg-D-Thr-lle-D-Val-Y, andZ-Gly-Val-Ile-Thr-Arg-Ile-Uwherein T is absent or is selected from N-protecting group and a polypeptide of up to 12 amino acid residues optionally terminated with a N-protecting group; U is selected from Arg and Arg-NR.sup.1 R.sup.2 wherein R.sup.1 and R.sup.2 are independently selected from hydrogen and alkyl of one to four carbon atoms; V is absent or a N-protecting group; W is selected from D-Arg and D-Arg-NR.sup.1 R.sup.2 ; X is absent or a N-protecting group; Y is selected from Gly and Gly-NR.sup.1 R.sup.2 ; and Z is 1-12 amino acid residues optionally terminated with a N-protecting group wherein at least one of the amino acid residues is a D-amino acid residue inhibit angiogenesis and are useful in the treatment of disease states such as cancer, arthritis, macular degeneration and diabetic retinopathyin which angiogenesis plays a role.Type: GrantFiled: March 16, 1998Date of Patent: August 3, 1999Assignee: Abbott LaboratoriesInventors: Jack Henkin, Noel P. Bouck, David W. Dawson, Andrew J. Schneider
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Patent number: 5192744Abstract: A method of inhibiting angiogenesis and preparations for use therein are disclosed. The preparations comprise human thrombospondin in trimer or monomer form or a fragment thereof capable of inhibiting vascularization. The method and preparations are especially applicable to the treatment of solid tumors including skin cancers for controlling tumor neovascularization and thereby arresting tumor enlargement.Type: GrantFiled: January 12, 1990Date of Patent: March 9, 1993Assignee: Northwestern UniversityInventors: Noel P. Bouck, Peter J. Polverini, Deborah J. Good, Farzan Rastinejad