Patents by Inventor Noelia BLANCO TALAVAN

Noelia BLANCO TALAVAN has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20220064610
    Abstract: PiggyBac transposases engineered to increase stability in a cell. The engineered piggyBac transposases are useful for stably transforming cells, cell line development, genome modification, and improving titer of recombinant proteins, among other uses.
    Type: Application
    Filed: December 9, 2019
    Publication date: March 3, 2022
    Applicant: AMGEN INC.
    Inventors: Neeraj J. AGRAWAL, Kristine M. DARIS, Jennitte L. STEVENS, Huong Thi Ngoc LE, Noelia Blanco TALAVAN
  • Publication number: 20210363178
    Abstract: The present disclosure relates to the production of multimeric polypeptides (e.g., comprising two or more subunits, each subunit comprising two or more polypeptide chains, such as a multispecific or bispecific antibody) in eukaryotic host cells. In some embodiments, provided herein are methods for producing a multimeric polypeptide in a eukaryotic host cell using a host cell that comprises a polynucleotide comprising a translation initiation sequence operably linked to an open-reading frame encoding each polypeptide of the multimeric polypeptide. Advantageously, the present disclosure demonstrates that tuning the strength of the translation initiation sequences linked to each open-reading frame allows for higher production of the multimeric polypeptide with fewer incorrectly assembled side products. The present disclosure further provides cells, methods of screening, and kits related thereto.
    Type: Application
    Filed: July 19, 2021
    Publication date: November 25, 2021
    Applicant: Genentech, Inc.
    Inventors: Laura C. SIMMONS, Noelia BLANCO TALAVAN