Patents by Inventor Noo Li Jeon

Noo Li Jeon has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11691148
    Abstract: A microfluidic device in which microfluidic channels are embedded in a culture medium chamber and have open sides. The microfluidic device is patterned with a fluid moved along a hydrophilic surface due to capillary force, and the fluid may be rapidly and uniformly patterned along an inner corner path and a microfluidic channel. In the microfluidic device, the microfluidic channel is connected to facilitate fluid flow with a culture medium through open sides thereof and openings, and thus may provide a cell culture environment in which high gas saturation is maintained. In addition, several microfluidic devices formed on one common substrate are described. Such microfluidic devices may be manufactured of a hydrophilic engineering plastic by injection molding.
    Type: Grant
    Filed: July 12, 2022
    Date of Patent: July 4, 2023
    Assignee: CURIOCHIPS
    Inventors: Noo Li Jeon, Byungjun Lee, James Yu, Jihoon Ko
  • Patent number: 11666938
    Abstract: Disclosed is a liquid patterning device and liquid patterning method. The liquid patterning device includes: a substrate having a flat bottom and a surface; at least one microstructure formed to vertically protrude from the surface of the substrate and including a plurality of unit microposts so as to have a desired shape; and a liquid mover for moving a liquid to be patterned on the surface of the substrate in another direction from one direction of the microstructure.
    Type: Grant
    Filed: March 18, 2021
    Date of Patent: June 6, 2023
    Assignee: CURIOSIS Co., Ltd.
    Inventors: Ho Young Yun, Myeong Woo Kang, Noo Li Jeon
  • Publication number: 20220347678
    Abstract: A microfluidic device in which microfluidic channels are embedded in a culture medium chamber and have open sides. The microfluidic device is patterned with a fluid moved along a hydrophilic surface due to capillary force, and the fluid may be rapidly and uniformly patterned along an inner corner path and a microfluidic channel. In the microfluidic device, the microfluidic channel is connected to facilitate fluid flow with a culture medium through open sides thereof and openings, and thus may provide a cell culture environment in which high gas saturation is maintained. In addition, several microfluidic devices formed on one common substrate are described. Such microfluidic devices may be manufactured of a hydrophilic engineering plastic by injection molding.
    Type: Application
    Filed: July 12, 2022
    Publication date: November 3, 2022
    Inventors: Noo Li JEON, Byungjun LEE, James YU, Jihoon KO
  • Publication number: 20220297117
    Abstract: Disclosed is a blood-brain barrier vascular network implemented in a microfluidic chip. The blood-brain bather vascular network structure (BBB on a chip) (in vitro blood-brain bather (BBB)-on-a chip) formed in a microfluidic chip manufactured by a present manufacturing method of the in vitro blood-brain barrier (BBB)-on-a chip may reconstruct the blood-brain barrier in a real human body more similarly due to a specific cell configuration, compared to the conventional in vitro blood-brain barrier (BBB)-on-a chip, and thus may be used as a more accurate in vitro blood-brain barrier, and may be used for the development of various cellular therapeutic agents or drugs that work in the treatment of various brain diseases.
    Type: Application
    Filed: March 30, 2021
    Publication date: September 22, 2022
    Applicants: UNIVERSITY-INDUSTRY COOPERATION GROUP OF KYUNG HEE UNIVERSITY, SEOUL NATIONAL UNIVERSITY R&DB FOUNDATION
    Inventors: Young-Sook SON, Su-Min KIM, Noo Li JEON, Somin LEE, Minhwan CHUNG
  • Patent number: 11383239
    Abstract: A microfluidic device in which microfluidic channels are embedded in a culture medium chamber and have open sides. The microfluidic device is patterned with a fluid moved along a hydrophilic surface due to capillary force, and the fluid may be rapidly and uniformly patterned along an inner corner path and a microfluidic channel. In the microfluidic device, the microfluidic channel is connected to facilitate fluid flow with a culture medium through open sides thereof and openings, and thus may provide a cell culture environment in which high gas saturation is maintained. In addition, several microfluidic devices formed on one common substrate are described. Such microfluidic devices may be manufactured of a hydrophilic engineering plastic by injection molding.
    Type: Grant
    Filed: December 19, 2019
    Date of Patent: July 12, 2022
    Assignee: CURIOCHIPS
    Inventors: Noo Li Jeon, Byungjun Lee, James Yu, Jihoon Ko
  • Publication number: 20210229127
    Abstract: Disclosed is a liquid patterning device and liquid patterning method. The liquid patterning device includes: a substrate having a flat bottom and a surface; at least one microstructure formed to vertically protrude from the surface of the substrate and including a plurality of unit microposts so as to have a desired shape; and a liquid mover for moving a liquid to be patterned on the surface of the substrate in another direction from one direction of the microstructure.
    Type: Application
    Filed: March 18, 2021
    Publication date: July 29, 2021
    Applicant: CURIOSIS Co., Ltd.
    Inventors: Ho Young YUN, Myeong Woo KANG, Noo Li JEON
  • Publication number: 20200156062
    Abstract: A microfluidic device in which microfluidic channels are embedded in a culture medium chamber and have open sides. The microfluidic device is patterned with a fluid moved along a hydrophilic surface due to capillary force, and the fluid may be rapidly and uniformly patterned along an inner corner path and a microfluidic channel. In the microfluidic device, the microfluidic channel is connected to facilitate fluid flow with a culture medium through open sides thereof and openings, and thus may provide a cell culture environment in which high gas saturation is maintained. In addition, several microfluidic devices formed on one common substrate are described. Such microfluidic devices may be manufactured of a hydrophilic engineering plastic by injection molding.
    Type: Application
    Filed: December 19, 2019
    Publication date: May 21, 2020
    Inventors: Noo Li JEON, Byungjun LEE, James YU, Jihoon KO
  • Publication number: 20190017999
    Abstract: The present invention relates to a micro-fluid chip for blood vessel formation. The micro-fluid chip of the present invention is constituted by first to fifth channels arranged adjacent to one another on a substrate in sequence, and two or more micro-structures or micro-posts having a gap therebetween are disposed on the interface that each channel forms together with an adjacent channel while contacting the same. Each channel performs a fluidic interaction with a different channel through the gap formed by the micro-structures, and biochemical materials can move therethrough. The micro-fluid chip, according to the present invention, provides a micro-blood vessel having a flat and continuous blood vessel interface outside a body. Furthermore, cancer angiogenesis, cancer intravasation, and cancer extravasation can be modeled using the micro-fluid chip of the present invention. In addition, the micro-fluid chip of the present invention can be used to screen candidate anti-cancer drugs.
    Type: Application
    Filed: September 4, 2015
    Publication date: January 17, 2019
    Inventors: Noo Li Jeon, Min Hwan Chung, Su Jung Oh, Woo Hyun Park, Hyun Jae Lee, Hyun Yul Ryu, Su Dong Kim
  • Publication number: 20180029070
    Abstract: Disclosed is a liquid patterning device and liquid patterning method. The liquid patterning device includes: a substrate having a flat bottom and a surface; at least one microstructure formed to vertically protrude from the surface of the substrate and including a plurality of unit microposts so as to have a desired shape; and a liquid mover for moving a liquid to be patterned on the surface of the substrate in another direction from one direction of the microstructure.
    Type: Application
    Filed: August 1, 2016
    Publication date: February 1, 2018
    Inventors: Ho Young YUN, Myeong Woo Kang, Noo Li JEON
  • Patent number: 9617520
    Abstract: Apparatuses, systems, and methods for generating concentration gradients of soluble molecules are disclosed herein. Devices and methods for generating in vitro blood vessels are also disclosed.
    Type: Grant
    Filed: September 16, 2015
    Date of Patent: April 11, 2017
    Assignee: SNU R&DB Foundation
    Inventors: Noo Li Jeon, Ju Hun Yeon, Qing Ping Hu, Sudong Kim, Hyun Jae Lee
  • Publication number: 20160102293
    Abstract: Apparatuses, systems, and methods for generating concentration gradients of soluble molecules are disclosed herein. Devices and methods for generating in vitro blood vessels are also disclosed.
    Type: Application
    Filed: September 16, 2015
    Publication date: April 14, 2016
    Inventors: Noo Li Jeon, Ju Hun Yeon, Qing Ping Hu, Sudong Kim, Hyun Jae Lee
  • Publication number: 20110244567
    Abstract: Provided herein are apparatuses, systems and methods for generating concentration gradients of soluble molecules. Also, provided herein devices and methods for generating in vitro blood vessels.
    Type: Application
    Filed: April 18, 2011
    Publication date: October 6, 2011
    Applicant: SNU R&DB FOUNDATION
    Inventors: Noo Li JEON, Ju Hun YEON, Qing Ping HU, Su Dong KIM, Hyun Jae LEE
  • Patent number: 7947491
    Abstract: The present invention relates to devices and systems that may generate and maintain a chemical gradient. In one embodiment, the invention provides a source and a sink channel so that a gradient bridge is created. In another embodiment, the gradient bridge creates a stable environment for facilitating molecular events to occur, such as a cell migration, or formation of crystallized molecules.
    Type: Grant
    Filed: August 31, 2007
    Date of Patent: May 24, 2011
    Assignee: The Regents of the University of California
    Inventors: Noo Li Jeon, Wajeeh Saadi, Seog Woo Rhee, Bobak Mosadegh, Carlos Huang
  • Patent number: 7942160
    Abstract: The present invention relates to microfluidic systems, including valves and pumps for microfluidic systems. The valves of the invention include check valves such as diaphragm valves and flap valves. Other valves of the invention include one-use valves. The pumps of the present invention include a reservoir and at least two check valves. The reservoir may be of variable volume. The present invention also relates to a flexible microfluidic system. The present invention additionally relates to a method of making microfluidic systems including those of the present invention. The method includes forming a microfluidic system on a master, connecting a support to the microfluidic system and removing the microfluidic system from the master. The support may remain connected to the microfluidic system or the microfluidic system may be transferred to another substrate. The present invention further relates to a method of manipulating a flow of a fluid in a microfluidic system.
    Type: Grant
    Filed: June 14, 2004
    Date of Patent: May 17, 2011
    Assignee: President and Fellows of Harvard College
    Inventors: Noo Li Jeon, Daniel T. Chiu, Christopher J. Wargo, Insung S. Choi, Hongkai Wu, Janelle R. Anderson, George M. Whitesides, J. Cooper McDonald, Steven J. Metallo, Howard A. Stone
  • Publication number: 20110003372
    Abstract: Provided herein are apparatuses, systems and methods for the efficient generation of gradients.
    Type: Application
    Filed: August 31, 2007
    Publication date: January 6, 2011
    Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Noo Li Jeon, Wajeeh Saadi, Seog Woo Rhee, Bobak Mosadegh, Carlos Huang
  • Publication number: 20080257735
    Abstract: A multi-compartment microfluidic device for enabling fluidic isolation among interconnected compartments and accomplishing centrifugal positioning and/or patterned substrate positioning of biological specimens. Includes micropatterned substrate coupled with optically transparent housing allowing imaging. Housing includes microfluidic region having entry reservoir for accepting first volume of fluid and additional microfluidic region(s) having a second entry reservoir for accepting second volume of fluid less than first volume of fluid to create hydrostatic pressure. A barrier region that couples the microfluidic region with the second microfluidic region enables biological specimen(s) to extend across the microfluidic, barrier region and second microfluidic region. The barrier region includes embedded microgroove(s) having width and height enabling second volume of fluid to be fluidically isolated from first volume of fluid via hydrostatic pressure maintained via the embedded microgroove(s).
    Type: Application
    Filed: September 26, 2005
    Publication date: October 23, 2008
    Applicant: REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Noo Li Jeon, Anne M. Taylor, Carl W. Cotman, David H. Cribbs
  • Patent number: 7419822
    Abstract: Embodiments of the invention are directed to a device that combines microfabrication, microfluidic, and surface micropatterning techniques to create a multi-compartment neuronal culturing device that has application across a number of different neuroscience uses. Devices configured in accordance with the invention allow directed growth of neurites and isolation of neurites from their cell bodies. The device can use hydrostatic pressure to isolate insults to one compartment and, thus, expose localized areas of neurons to insults. Due to the high resistance of the microgrooves for fluid transport, insults are contained in the neuritic compartment without appreciable leakage into the somal compartment for a certain period of time (e.g., over 15 h).
    Type: Grant
    Filed: October 6, 2003
    Date of Patent: September 2, 2008
    Inventors: Noo Li Jeon, Carl Cotman, Anne M. Taylor
  • Patent number: 7314070
    Abstract: A method and apparatus for treating a fluid. A method for treating a fluid may include combining two or more separate streams into a common stream and then splitting the common stream into a new set of separate streams wherein the separate streams may possess different properties. The separate streams may be combined to produce a gradient, such as a concentration gradient or shear gradient. The apparatus of the invention may provide a network of fluidic channels that may be used to manipulate a fluid to produce, for example, a gradient or a series of solutions containing a substance at varying concentrations.
    Type: Grant
    Filed: January 18, 2005
    Date of Patent: January 1, 2008
    Assignee: President and Fellows of Harvard College
    Inventors: Noo Li Jeon, Stephan K. W. Dertinger, Daniel T. Chiu, Insung S. Choi, George M. Whitesides
  • Patent number: 7267938
    Abstract: The present invention describes improved microfluidic systems and procedures for fabricating improved microfluidic systems, which contain one or more levels of microfluidic channels. The methods for fabrication the systems disclosed can provide a convenient route to topologically complex and improved microfluidic systems. The microfluidic systems can include three-dimensionally arrayed networks of fluid flow paths therein including channels that cross over or under other channels of the network without physical intersection at the points of cross over. The microfluidic networks can be fabricated via replica molding processes utilizing mold masters including surfaces having topological features formed by photolithography. The present invention also involves microfluidic systems and methods for fabricating complex patterns of materials, such as biological materials and cells, on surfaces utilizing the microfluidic systems.
    Type: Grant
    Filed: September 2, 2003
    Date of Patent: September 11, 2007
    Assignee: President and Fellows of Harvard College
    Inventors: Janelle R. Anderson, Daniel T. Chiu, Noo Li Jeon, Sui Huang, Ravindra Kane, Insung S. Choi, Donald E. Ingber, George M. Whitesides
  • Publication number: 20060018838
    Abstract: Tissue engineering holds enormous potential to replace or restore function to a wide range of tissues. However, the most successful applications have been limited to thin avascular tissues in which delivery of essential nutrients occurs primarily by diffusion. Pursuant to the present invention, a prevascularized, thick tissue construct is created having a network of capillaries with lumens capable of nutrient and origin delivery and forming anastamoses to host vasculature. A tissue transplantation strategy is comprised of (1) in vitro vascularization of a tisue construct, (2) transplantation of prevascularized tissue to wound bed of host where vessels of implantable tissue and host rapidly anastomose, and (3) host-directed remodeling and reorganization of the tissue and vascular network.
    Type: Application
    Filed: March 12, 2003
    Publication date: January 26, 2006
    Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Steven George, Noo Li Jeon, Chris Hughes