Patents by Inventor Noor Jailkhani

Noor Jailkhani has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • NANOBODY BASED IMAGING AND TARGETING OF ECM IN DISEASE AND DEVELOPMENT
    Publication number: 20230348605
    Abstract: Methods for developing disease-related nanobodies and related products and kits are provided. The disease-specific proteins are extracellular matrix (ECM) proteins, domains or epitopes that are associated with various aspects of disease and are not present, or are present in very low quantities, in non-diseased individuals. Highly effective nanobodies capable of specifically binding to these ECM protein epitopes useful in in vivo imaging assays, the detection, diagnosis and treatment of diseases as well as monitoring therapeutic progress in a patient with a disease are provided herein.
    Type: Application
    Filed: February 28, 2023
    Publication date: November 2, 2023
    Applicants: Massachusetts Institute of Technology, Children's Medical Center Corporation, Whitehead Institute for Biomedical Research
    Inventors: Richard O. Hynes, Noor Jailkhani, Hidde L. Ploegh, Yushu J. Xie
  • ENHANCED-AFFINITY ANTI-ECM NANOBODY-CYTOKINE FUSIONS AND THEIR APPLICATIONS
    Publication number: 20230295284
    Abstract: Provided herein are anti-FN-EIIIB nanobodies, conjugates thereof, and methods of using the nanobodies and conjugates thereof.
    Type: Application
    Filed: January 31, 2023
    Publication date: September 21, 2023
    Applicant: Massachusetts Institute of Technology
    Inventors: Richard O. Hynes, Karl Dane Wittrup, Noor Jailkhani, Noor Momin, Emi Lutz
  • Nanobody based imaging and targeting of ECM in disease and development
    Patent number: 11597769
    Abstract: Methods for developing disease-related nanobodies and related products and kits are provided. The disease-specific proteins are extracellular matrix (ECM) proteins, domains or epitopes that are associated with various aspects of disease and are not present, or are present in very low quantities, in non-diseased individuals. Highly effective nanobodies capable of specifically binding to these ECM protein epitopes useful in in vivo imaging assays, the detection, diagnosis and treatment of diseases as well as monitoring therapeutic progress in a patient with a disease are provided herein.
    Type: Grant
    Filed: January 25, 2019
    Date of Patent: March 7, 2023
    Assignees: Massachusetts Institute of Technology, Children's Medical Center Corporation, Whitehead Institute for Biomedical Research
    Inventors: Richard O. Hynes, Noor Jailkhani, Hidde L. Ploegh, Yushu Joy Xie
  • NANOBODY BASED IMAGING AND TARGETING OF ECM IN DISEASE AND DEVELOPMENT
    Publication number: 20190225693
    Abstract: Methods for developing disease-related nanobodies and related products and kits are provided. The disease-specific proteins are extracellular matrix (ECM) proteins, domains or epitopes that are associated with various aspects of disease and are not present, or are present in very low quantities, in non-diseased individuals. Highly effective nanobodies capable of specifically binding to these ECM protein epitopes useful in in vivo imaging assays, the detection, diagnosis and treatment of diseases as well as monitoring therapeutic progress in a patient with a disease are provided herein.
    Type: Application
    Filed: January 25, 2019
    Publication date: July 25, 2019
    Applicant: Massachusetts Institute of Technology
    Inventors: Richard O. Hynes, Noor Jailkhani