Patents by Inventor Nor Lizawati Ibrahim

Nor Lizawati Ibrahim has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 9987369
    Abstract: Gel-forming block copolymers were prepared comprising i) a central hydrophilic block consisting essentially of a divalent poly(ethylene oxide) chain and ii) two peripheral monocarbonate or polycarbonate hydrophobic blocks linked to the central block by linking groups bearing one or more hydrogen bond forming *—N(H)—* groups. The hydrophobic blocks comprise one or more vitamin-bearing subunits. The gel-forming block copolymers can be used to prepare various biodegradable and/or biocompatible hydrogel and organogel drug compositions, in particular antimicrobial and/or anti-tumor drug compositions. The hydrogel compositions have utility in depot injections for drug delivery. The hydrogen bonding *—N(H)—* group(s) provide longer in vivo lifetime of the hydrogel before degradation and a more prolonged and controlled release rate of a hydrophobic drug compared to similar hydrogels prepared from poly(ethylene glycol).
    Type: Grant
    Filed: November 1, 2016
    Date of Patent: June 5, 2018
    Assignees: International Business Machines Corporation, Agency For Science, Technology And Research
    Inventors: Wei Cheng, Mareva B. Fevre, James L. Hedrick, Nor Lizawati Ibrahim, Ashlynn L. Z. Lee, Victor W. L. Ng, Robert J. Ono, Chuan Yang, Yi Yan Yang
  • Publication number: 20180117162
    Abstract: Gel-forming block copolymers were prepared comprising i) a central hydrophilic block consisting essentially of a divalent poly(ethylene oxide) chain and ii) two peripheral monocarbonate or polycarbonate hydrophobic blocks linked to the central block by linking groups bearing one or more hydrogen bond forming *—N(H)—* groups. The hydrophobic blocks comprise one or more vitamin-bearing subunits. The gel-forming block copolymers can be used to prepare various biodegradable and/or biocompatible hydrogel and organogel drug compositions, in particular antimicrobial and/or anti-tumor drug compositions. The hydrogel compositions have utility in depot injections for drug delivery. The hydrogen bonding *—N(H)—* group(s) provide longer in vivo lifetime of the hydrogel before degradation and a more prolonged and controlled release rate of a hydrophobic drug compared to similar hydrogels prepared from poly(ethylene glycol).
    Type: Application
    Filed: November 1, 2016
    Publication date: May 3, 2018
    Inventors: Wei Cheng, Mareva B. Fevre, James L. Hedrick, Nor Lizawati Ibrahim, Ashlynn L.Z. Lee, Victor W.L. Ng, Robert J. Ono, Chuan Yang, Yi Yan Yang
  • Patent number: 9854806
    Abstract: Antimicrobial cationic polycarbonates and polyurethanes have been prepared comprising one or more pendent guanidinium and/or isothiouronium groups. Additionally, antimicrobial particles were prepared having a silica core linked to surface groups comprising a guanidinium and/or isothiouronium group. The cationic polymers and cationic particles can be potent antimicrobial agents against Gram-negative microbes, Gram-positive microbes, and/or fungi.
    Type: Grant
    Filed: May 19, 2015
    Date of Patent: January 2, 2018
    Assignees: International Business Machines Corporation, Agency For Science, Technology And Research
    Inventors: Willy Chin, James L. Hedrick, Nor Lizawati Ibrahim, Ashlynn L. Z. Lee, Robert J. Ono, Qingxing Xu, Yi Yan Yang
  • Publication number: 20160338356
    Abstract: Antimicrobial cationic polycarbonates and polyurethanes have been prepared comprising one or more pendent guanidinium and/or isothiouronium groups. Additionally, antimicrobial particles were prepared having a silica core linked to surface groups comprising a guanidinium and/or isothiouronium group. The cationic polymers and cationic particles can be potent antimicrobial agents against Gram-negative microbes, Gram-positive microbes, and/or fungi.
    Type: Application
    Filed: May 19, 2015
    Publication date: November 24, 2016
    Inventors: Willy Chin, James L. Hedrick, Nor Lizawati Ibrahim, Ashlynn L. Z. Lee, Robert J. Ono, Qingxing Xu, Yi Yan Yang