Abstract: The present invention provides compounds able to induce neuroprotection of damaged neurons and boost the remyelination potential of oligodendrocytes. The compounds have been identified through methods of pharmacological screening of a small molecule library consisting of known pharmacologically active compounds and approved drugs. The screening method is also included in the invention.

Abstract: Systems and methods for reducing an overpressure caused by an explosion of a vapor cloud are provided. In one or more embodiments, the system can include one or more sensors operable to detect the explosion of the vapor cloud. The system can also include one or more igniters operable to ignite the vapor cloud at locations throughout, after the explosion of the vapor cloud is detected, to provide a discrete combustion zone at each location. Each combustion zone can form a discrete pressure wave, thereby reducing the overpressure caused by the explosion of the vapor cloud.

Abstract: Systems and methods for reducing an overpressure caused by an explosion of a vapor cloud are provided. In one or more embodiments, the system can include one or more sensors operable to detect the explosion of the vapor cloud. The system can also include one or more igniters operable to ignite the vapor cloud at locations throughout, after the explosion of the vapor cloud is detected, to provide a discrete combustion zone at each location. Each combustion zone can form a discrete pressure wave, thereby reducing the overpressure caused by the explosion of the vapor cloud.

Abstract: Copolymers, and processes to make them, are provided which are derived from monomers comprising: a) one mono-olefin having a single Ziegler-Natta polymerizable bond; b) a second monomer having at least one Ziegler-Natta polymerizable bond; c) a third monomer having at least two Ziegler-Natta polymerizable bonds such monomer being: i) straight-chained and of less than six or at least seven carbon atoms; ii) other than straight chained; or iii) combinations thereof, such copolymer having: c) at least about one carbon-carbon unsaturated bond per number average molecule; d) viscous energy of activation (Ea) at least 1 kcal/mol greater than a copolymer having a linear backbone derived from same monomers, but excluding species having at least two Ziegler-Natta polymerizable bonds; e) crystallinity level of about 10% to about 50%; and f) Mz/Mw at least about 1.7. Such copolymers show enhanced melt processability and other attributes during end-product fabrication.

Abstract: The invention relates to processes for producing polyolefins at pressures substantially below conventional high pressure conditions in two-phase conditions below the cloud point. The invention can involve a continuous system with optional recycle.

Abstract: The invention provides a continuous process for catalytically polymerizing a monomer feed of ethylene and at least one comonomer which comprises introducing a catalyst including a bulky ancillary ligand transition metal compound and monomer feed in an upstream reaction zone for polymerization, introducing further catalyst in a downstream reaction zone for further polymerization, the peak temperature in the downstream reaction zone being at least 50.degree. C. higher than in the upstream zone and being above 150.degree. C. The process economically produces polymer of good properties which is melt processable.

Abstract: A process for preparing olefinic polymers by metallocene catalyzed olefin polymerisation in which at least one volatile catalyst kill agent is introduced. A non-volatile catalyst kill agent may also be used in conjunction with the volatile catalyst kill agent. Water may be used as the volatile agent and compounds containing a terminal hydroxy group, oxygen, nitrogen or sulfur may constitute the non-volatile agent. Purified monomer is recycled to the reactor.