Patents by Inventor Norbert Beier

Norbert Beier has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 5739142
    Abstract: 4-Aminobenzoylguanidines of the formula I ##STR1## in which A, R.sub.1, R.sub.2 and R.sub.3 have the meanings given, and the physiologically unobjectionable salts thereof exhibit antiarrhythmic properties and are active as inhibitors of the cellular Na.sup.+ /H.sup.+ antiporter.
    Type: Grant
    Filed: January 26, 1996
    Date of Patent: April 14, 1998
    Assignee: Merck Patent Gesellschaft Mit Beschrankter Haftung
    Inventors: Rolf Gericke, Manfred Haumgarth, Norbert Beier, Klaus-Otto Minck
  • Patent number: 5731351
    Abstract: Alkyl-benzoylguanidines of the formula I ##STR1## wherein R.sup.1, R.sup.2 and R.sup.3 have the meanings given, and physiologically acceptable salts thereof show antiarrhythmic properties and act as inhibitors of the cellular Na.sup.+ /H.sup.+ antiporter.
    Type: Grant
    Filed: August 23, 1996
    Date of Patent: March 24, 1998
    Assignee: Merck Patent Gesellschaft mit Beschrankter Haftung
    Inventors: Rolf Gericke, Manfred Baumgarth, Klaus-Otto Minck, Norbert Beier
  • Patent number: 5705497
    Abstract: 3-Alkoxycarbonyl thiadiazinones of the formula I ##STR1## and physiologically unobjectionable salts thereof, in which R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5, Q and n have the meanings described herein, exhibit a positively inotropic action and can be employed for the therapy of cardiac insufficiency.
    Type: Grant
    Filed: January 11, 1996
    Date of Patent: January 6, 1998
    Assignee: Merck Patent Gesellschaft mit beschrankter Haftung
    Inventors: Rochus Jonas, Inge Lues, Norbert Beier, Klaus-Otto Minck
  • Patent number: 5700839
    Abstract: Benzoylguanidines of the formula I ##STR1## wherein R.sup.1 and R.sup.2 have the meanings indicated herein, and their physiologically acceptable salts, show anti-arrhythmic properties and act as inhibitors of the cellular NA.sup.+ /H.sup.+ antiporter.
    Type: Grant
    Filed: October 20, 1995
    Date of Patent: December 23, 1997
    Assignee: Merck Patent Gesellschaft mit Beschrankter Haftung
    Inventors: Rolf Gericke, Dieter Dorsch, Manfred Baumgarth, Klaus-Otto Minck, Norbert Beier
  • Patent number: 5696167
    Abstract: 4-Mercaptobenzoylguanidines of the formula I ##STR1## in which A, R.sub.1, R.sub.2 and R.sub.3 have the meanings given, and the physiologically unobjectionable salts thereof exhibit antiarrhythmic properties and are active as inhibitors of the cellular Na.sup.+ /H.sup.+ antiporter.
    Type: Grant
    Filed: January 30, 1996
    Date of Patent: December 9, 1997
    Assignee: Merck Patent Gesellschaft mit beschrankter Haftung
    Inventors: Rolf Gericke, Manfred Baumgarth, Klaus-Otto Minck, Norbert Beier
  • Patent number: 5684015
    Abstract: Described herein are novel imidazopyridine derivatives of the formula I ##STR1## wherein R is ##STR2## and R.sup.1, R.sup.2, R.sup.3 and R.sup.4 are as defined in Patent Claim 1, and their salts, which exhibit antagonistic properties towards angiotensin II and can be used for the treatment of hypertension, aldosteronism, cardiac insufficiency and increased intraocular pressure, and of disorders of the central nervous system.
    Type: Grant
    Filed: September 14, 1995
    Date of Patent: November 4, 1997
    Assignee: Merck Patent Gesellschaft mit Beschrankter Haftung
    Inventors: Werner Mederski, Matthias Osswald, Pierre Schelling, Klaus-Otto Minck, Dieter Dorsch, Norbert Beier, Ingeborg Lues
  • Patent number: 5532276
    Abstract: Novel imidazopyridine derivatives of the formula ##STR1## wherein R is ##STR2## and R.sup.1, R.sup.2, R.sup.3, R.sup.4, Ar.sup.1, X and Y are as defined in the specification, and their salts, exhibit antagonistic properties toward angiotensin II and can be used for the treatment of hypertension, aldosteronism, cardiac insufficiency and increased intraocular pressure, and of disorders of the central nervous system.
    Type: Grant
    Filed: December 5, 1994
    Date of Patent: July 2, 1996
    Assignee: Merck Patent Gesellschaft mit beschrankter Haftung
    Inventors: Werner Mederski, Dieter Dorsch, Mathias Osswald, Norbert Beier, Pierre Schelling, Klaus-Otto Minck, Ingeborg Lues
  • Patent number: 5495022
    Abstract: Piperidine and piperazine derivatives of formula I ##STR1## wherein R.sup.1 and R.sup.2 are H or A,R.sup.3, R.sup.4 and R.sup.5 are each independently H, Hal, OH, OA, OAc, NO.sub.2, NH.sub.2, NHAc, NHSO.sub.2 A or CN, orR.sup.3 and R.sup.4 together are --O--(CH.sub.2).sub.m --O--,n is 0, 1 or 2X is O or CH.sub.2, if n=0 or 2, or CH.sub.2, NH, NA or NAc, if n=1,Y is CH or N,m is 1 or 2,Hal is F, Cl, Br or I,A is C.sub.1-6 -alkyl,Ac is C.sub.1-8 -alkanoyl C.sub.1-10 -aralkanoyl or C.sub.7-11 -aroyl,and their physiologically acceptable salts show antiarrhythmic effects.
    Type: Grant
    Filed: June 24, 1994
    Date of Patent: February 27, 1996
    Assignee: Merck Patent Gesellschaft mit beschrankter Haftung
    Inventors: Manfred Baumgarth, Inge Lues, Klaus-Otto Minck, Norbert Beier
  • Patent number: 5476857
    Abstract: Novel imidazopyridine derivatives of formula I: ##STR1## wherein R is ##STR2## and R.sup.1, R.sup.2, R.sup.3, R.sup.4, X and Y are as defined herein, and their salts, exhibit antagonistic properties toward angiotensin II and can be used for the treatment of hypertension, aldosteronism, cardiac insufficiency and increased intraocular pressure, and of disorders of the central nervous system.
    Type: Grant
    Filed: June 17, 1993
    Date of Patent: December 19, 1995
    Assignee: Merck Patent Gesellschaft mit Beschrankter Haftung
    Inventors: Werner Mederski, Dieter Dorsch, Norbert Beier, Pierre Schelling, Ingeborg Lues, Klaus-Otto Minck, Mathias Osswald
  • Patent number: 5461066
    Abstract: 4-amino-1-piperidylbenzoylguanidines of the formula I ##STR1## in which R.sup.1, R.sup.2, R.sup.3 and R.sup.4 have the given meanings, and also the physiologically compatible salts thereof, exhibit antiarrhythmic properties and act as inhibitors of the cellular Na.sup.+ /H.sup.+ antiporter.
    Type: Grant
    Filed: February 9, 1995
    Date of Patent: October 24, 1995
    Assignee: Merck Patent Gesellschaft mit beschrankter Haftung
    Inventors: Rolf Gericke, Manfred Baumgarth, Dieter Dorsch, Norbert Beier, Klaus-Otto Minck, Ingeborg Lues
  • Patent number: 5438063
    Abstract: Novel imidazopyridine derivatives of formula I ##STR1## wherein ##STR2## and R.sup.1, R.sup.2, R.sup.3, R.sup.4, X and Y are as defined herein, and their salts, exhibit antagonistic properties toward angiotensin II and can be used for the treatment of hypertension, aldosteronism, cardiac insufficiency and increased intraocular pressure, and of disorders of the central nervous system.
    Type: Grant
    Filed: June 6, 1994
    Date of Patent: August 1, 1995
    Assignee: Merck Patent Gesellschaft mit beschrankter Haftung
    Inventors: Mathias Osswald, Werner Mederski, Dieter Dorsch, Pierre Schelling, Norbert Beier, Ingeborg Lues, Klaus-Otto Minck
  • Patent number: 5405964
    Abstract: Novel imidazopyridine derivatives of formula I ##STR1## and X, --Y.dbd.Z--, R.sup.1, R.sup.2, R.sup.3, R.sup.4 and R.sup.5 as defined herein, and their salts, exhibit antagonistic properties towards angiotensin II and can be used for the treatment of hypertension, aldosteronism, cardiac insufficiency and increased intraocular pressure, and of disorders of the central nervous system.
    Type: Grant
    Filed: October 22, 1993
    Date of Patent: April 11, 1995
    Assignee: Merck Patent Gesellschaft mit beschrankter Haftung
    Inventors: Werner Mederski, Dieter Dorsch, Andreas Bathe, Thorsten Hartig, Mathias Osswald, Norbert Beier, Pierre Schelling, Klaus-Otto Minck, Ingeborg Lues
  • Patent number: 5401738
    Abstract: Benzimidazole compounds of the formula I ##STR1## and salts thereof, exhibit antagonistic properties toward angiotensin II and can be used for the treatment of hypertension, aldosteronism, cardiac insufficiency and an increased intraocular pressure, as well as disturbances of the central nervous system.
    Type: Grant
    Filed: June 11, 1993
    Date of Patent: March 28, 1995
    Assignee: Merck Patent Gesellschaft mit beschrankter
    Inventors: Werner Mederski, Dieter Dorsch, Norbert Beier, Pierre Schelling, Ingeborg Lues, Klaus-Otto Minck, Mathias Osswald
  • Patent number: 5389642
    Abstract: Novel imidazopyridine derivatives of the formula I ##STR1## in which R is ##STR2## and R.sup.1 to R.sup.4, X and Y are as defined herein, and their salts have antagonistic properties towards angiotensin(II) and can be used for the treatment of hypertension, aldosteronism, cardiac insufficiency and increased intraocular pressure and also disorders of the central nervous system.
    Type: Grant
    Filed: December 16, 1993
    Date of Patent: February 14, 1995
    Assignee: Merck Patent Gesellschaft Mit Beschrankter Haftung
    Inventors: Dieter Dorsch, Werner Mederski, Mathias Osswald, Pierre Schelling, Norbert Beier, Ingeborg Lues, Klaus-Otto Minck
  • Patent number: 5371226
    Abstract: 2-oxoquinoline derivative of formula I; ##STR1## wherein R is ##STR2## and R.sup.1 to R.sup.6 and X are as defined in claim 1, and their salts exhibit antagonistic properties towards angiotensin II and have inter alia a hypotensive action.
    Type: Grant
    Filed: March 16, 1993
    Date of Patent: December 6, 1994
    Assignee: Merck Patent Gesellschaft Mit Beschrankter Haftung
    Inventors: Werner Mederski, Dieter Dorsch, Norbert Beier, Ingeborg Lues, Klaus-Otto Minck, Pierre Schelling
  • Patent number: 5332750
    Abstract: New 1,2-dihydro-2-oxopyridines of formula I ##STR1## in which R is the radical ##STR2## and R.sup.1 to R.sup.6 and X are as defined herein,and their salts, have antagonistic properties towards angiotensin II and can be used for the treatment of hypertension, aldosteronism and cardiac insufficiency.
    Type: Grant
    Filed: April 22, 1993
    Date of Patent: July 26, 1994
    Assignee: Merck Patent Gesellschaft mit beschrankter Haftung
    Inventors: Werner Mederski, Norbert Beier, Pierre Schelling, Ingeborg Lues, Klaus-Otto Minck
  • Patent number: 5242928
    Abstract: Novel imidazopyridine derivatives of formula I: ##STR1## wherein R is ##STR2## R.sup.1 is A, alkenyl or alkynyl each having up to 6 C atoms, R.sup.2 is H, COOH, COOA, CN, NO.sub.2, NHCOR.sup.5, NHSO.sub.2 R.sup.5 or 1H-tetrazol-5-yl,R.sup.3 is R.sup.5 --CO--alkyl, Ar--CO--alkyl, Het--CO--alkyl or Het-alkyl each having 1-6 C atoms in the alkyl moiety,R.sup.4 is H or Hal,R.sup.5 is alkyl having 1-6 C atoms, wherein one or more H atoms can also be replaced with F,X is absent or is --NH--CO--, --CO--NH--, --O--CH(COOH)--, --NH--CH(COOH)--, --NA--CH(COOH)--, --CH.dbd.C(COOH)--, --CH.dbd.C(CN)-- OR --CH.dbd.C(1H-tetrazol-t-yl)--,Y is O or S,A is alkyl having 1-6 C atoms,Ar is unsubstituted phenyl or phenyl monosubstituted by R.sup.5, OR.sup.5, COOH, COOA, CN, NO.sub.2, NH.sub.2, NHCOR.sup.5, NHSO.sub.2 R.sup.
    Type: Grant
    Filed: December 17, 1992
    Date of Patent: September 7, 1993
    Assignee: Merck Patent Gesellschaft mit beschrankter Haftung
    Inventors: Werner Mederski, Dieter Dorsch, Norbert Beier, Pierre Schelling, Ingeborg Lues, Klaus-Otto Minck
  • Patent number: 5137885
    Abstract: Thiadiazinones of the formula I ##STR1## in which R.sup.1, R.sup.2, R.sup.3, R.sup.4 and R.sup.5 have the meaning given in claim 1, show positively inotropic and vasodilating action and are suitable for combating cardiovascular diseases.
    Type: Grant
    Filed: December 20, 1991
    Date of Patent: August 11, 1992
    Assignee: Merck Patent Gesellschaft Mit Beschraenkter Haftung
    Inventors: Rochus Jonas, Ingeborg Lues, Norbert Beier, Michael Klockow, Klaus-Otto Minck