Patents by Inventor Norbert Beier
Norbert Beier has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
-
Patent number: 5739142Abstract: 4-Aminobenzoylguanidines of the formula I ##STR1## in which A, R.sub.1, R.sub.2 and R.sub.3 have the meanings given, and the physiologically unobjectionable salts thereof exhibit antiarrhythmic properties and are active as inhibitors of the cellular Na.sup.+ /H.sup.+ antiporter.Type: GrantFiled: January 26, 1996Date of Patent: April 14, 1998Assignee: Merck Patent Gesellschaft Mit Beschrankter HaftungInventors: Rolf Gericke, Manfred Haumgarth, Norbert Beier, Klaus-Otto Minck
-
Patent number: 5731351Abstract: Alkyl-benzoylguanidines of the formula I ##STR1## wherein R.sup.1, R.sup.2 and R.sup.3 have the meanings given, and physiologically acceptable salts thereof show antiarrhythmic properties and act as inhibitors of the cellular Na.sup.+ /H.sup.+ antiporter.Type: GrantFiled: August 23, 1996Date of Patent: March 24, 1998Assignee: Merck Patent Gesellschaft mit Beschrankter HaftungInventors: Rolf Gericke, Manfred Baumgarth, Klaus-Otto Minck, Norbert Beier
-
Patent number: 5705497Abstract: 3-Alkoxycarbonyl thiadiazinones of the formula I ##STR1## and physiologically unobjectionable salts thereof, in which R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5, Q and n have the meanings described herein, exhibit a positively inotropic action and can be employed for the therapy of cardiac insufficiency.Type: GrantFiled: January 11, 1996Date of Patent: January 6, 1998Assignee: Merck Patent Gesellschaft mit beschrankter HaftungInventors: Rochus Jonas, Inge Lues, Norbert Beier, Klaus-Otto Minck
-
Patent number: 5700839Abstract: Benzoylguanidines of the formula I ##STR1## wherein R.sup.1 and R.sup.2 have the meanings indicated herein, and their physiologically acceptable salts, show anti-arrhythmic properties and act as inhibitors of the cellular NA.sup.+ /H.sup.+ antiporter.Type: GrantFiled: October 20, 1995Date of Patent: December 23, 1997Assignee: Merck Patent Gesellschaft mit Beschrankter HaftungInventors: Rolf Gericke, Dieter Dorsch, Manfred Baumgarth, Klaus-Otto Minck, Norbert Beier
-
Patent number: 5696167Abstract: 4-Mercaptobenzoylguanidines of the formula I ##STR1## in which A, R.sub.1, R.sub.2 and R.sub.3 have the meanings given, and the physiologically unobjectionable salts thereof exhibit antiarrhythmic properties and are active as inhibitors of the cellular Na.sup.+ /H.sup.+ antiporter.Type: GrantFiled: January 30, 1996Date of Patent: December 9, 1997Assignee: Merck Patent Gesellschaft mit beschrankter HaftungInventors: Rolf Gericke, Manfred Baumgarth, Klaus-Otto Minck, Norbert Beier
-
Patent number: 5684015Abstract: Described herein are novel imidazopyridine derivatives of the formula I ##STR1## wherein R is ##STR2## and R.sup.1, R.sup.2, R.sup.3 and R.sup.4 are as defined in Patent Claim 1, and their salts, which exhibit antagonistic properties towards angiotensin II and can be used for the treatment of hypertension, aldosteronism, cardiac insufficiency and increased intraocular pressure, and of disorders of the central nervous system.Type: GrantFiled: September 14, 1995Date of Patent: November 4, 1997Assignee: Merck Patent Gesellschaft mit Beschrankter HaftungInventors: Werner Mederski, Matthias Osswald, Pierre Schelling, Klaus-Otto Minck, Dieter Dorsch, Norbert Beier, Ingeborg Lues
-
Patent number: 5532276Abstract: Novel imidazopyridine derivatives of the formula ##STR1## wherein R is ##STR2## and R.sup.1, R.sup.2, R.sup.3, R.sup.4, Ar.sup.1, X and Y are as defined in the specification, and their salts, exhibit antagonistic properties toward angiotensin II and can be used for the treatment of hypertension, aldosteronism, cardiac insufficiency and increased intraocular pressure, and of disorders of the central nervous system.Type: GrantFiled: December 5, 1994Date of Patent: July 2, 1996Assignee: Merck Patent Gesellschaft mit beschrankter HaftungInventors: Werner Mederski, Dieter Dorsch, Mathias Osswald, Norbert Beier, Pierre Schelling, Klaus-Otto Minck, Ingeborg Lues
-
Patent number: 5495022Abstract: Piperidine and piperazine derivatives of formula I ##STR1## wherein R.sup.1 and R.sup.2 are H or A,R.sup.3, R.sup.4 and R.sup.5 are each independently H, Hal, OH, OA, OAc, NO.sub.2, NH.sub.2, NHAc, NHSO.sub.2 A or CN, orR.sup.3 and R.sup.4 together are --O--(CH.sub.2).sub.m --O--,n is 0, 1 or 2X is O or CH.sub.2, if n=0 or 2, or CH.sub.2, NH, NA or NAc, if n=1,Y is CH or N,m is 1 or 2,Hal is F, Cl, Br or I,A is C.sub.1-6 -alkyl,Ac is C.sub.1-8 -alkanoyl C.sub.1-10 -aralkanoyl or C.sub.7-11 -aroyl,and their physiologically acceptable salts show antiarrhythmic effects.Type: GrantFiled: June 24, 1994Date of Patent: February 27, 1996Assignee: Merck Patent Gesellschaft mit beschrankter HaftungInventors: Manfred Baumgarth, Inge Lues, Klaus-Otto Minck, Norbert Beier
-
Patent number: 5476857Abstract: Novel imidazopyridine derivatives of formula I: ##STR1## wherein R is ##STR2## and R.sup.1, R.sup.2, R.sup.3, R.sup.4, X and Y are as defined herein, and their salts, exhibit antagonistic properties toward angiotensin II and can be used for the treatment of hypertension, aldosteronism, cardiac insufficiency and increased intraocular pressure, and of disorders of the central nervous system.Type: GrantFiled: June 17, 1993Date of Patent: December 19, 1995Assignee: Merck Patent Gesellschaft mit Beschrankter HaftungInventors: Werner Mederski, Dieter Dorsch, Norbert Beier, Pierre Schelling, Ingeborg Lues, Klaus-Otto Minck, Mathias Osswald
-
Patent number: 5461066Abstract: 4-amino-1-piperidylbenzoylguanidines of the formula I ##STR1## in which R.sup.1, R.sup.2, R.sup.3 and R.sup.4 have the given meanings, and also the physiologically compatible salts thereof, exhibit antiarrhythmic properties and act as inhibitors of the cellular Na.sup.+ /H.sup.+ antiporter.Type: GrantFiled: February 9, 1995Date of Patent: October 24, 1995Assignee: Merck Patent Gesellschaft mit beschrankter HaftungInventors: Rolf Gericke, Manfred Baumgarth, Dieter Dorsch, Norbert Beier, Klaus-Otto Minck, Ingeborg Lues
-
Patent number: 5438063Abstract: Novel imidazopyridine derivatives of formula I ##STR1## wherein ##STR2## and R.sup.1, R.sup.2, R.sup.3, R.sup.4, X and Y are as defined herein, and their salts, exhibit antagonistic properties toward angiotensin II and can be used for the treatment of hypertension, aldosteronism, cardiac insufficiency and increased intraocular pressure, and of disorders of the central nervous system.Type: GrantFiled: June 6, 1994Date of Patent: August 1, 1995Assignee: Merck Patent Gesellschaft mit beschrankter HaftungInventors: Mathias Osswald, Werner Mederski, Dieter Dorsch, Pierre Schelling, Norbert Beier, Ingeborg Lues, Klaus-Otto Minck
-
Patent number: 5405964Abstract: Novel imidazopyridine derivatives of formula I ##STR1## and X, --Y.dbd.Z--, R.sup.1, R.sup.2, R.sup.3, R.sup.4 and R.sup.5 as defined herein, and their salts, exhibit antagonistic properties towards angiotensin II and can be used for the treatment of hypertension, aldosteronism, cardiac insufficiency and increased intraocular pressure, and of disorders of the central nervous system.Type: GrantFiled: October 22, 1993Date of Patent: April 11, 1995Assignee: Merck Patent Gesellschaft mit beschrankter HaftungInventors: Werner Mederski, Dieter Dorsch, Andreas Bathe, Thorsten Hartig, Mathias Osswald, Norbert Beier, Pierre Schelling, Klaus-Otto Minck, Ingeborg Lues
-
Patent number: 5401738Abstract: Benzimidazole compounds of the formula I ##STR1## and salts thereof, exhibit antagonistic properties toward angiotensin II and can be used for the treatment of hypertension, aldosteronism, cardiac insufficiency and an increased intraocular pressure, as well as disturbances of the central nervous system.Type: GrantFiled: June 11, 1993Date of Patent: March 28, 1995Assignee: Merck Patent Gesellschaft mit beschrankterInventors: Werner Mederski, Dieter Dorsch, Norbert Beier, Pierre Schelling, Ingeborg Lues, Klaus-Otto Minck, Mathias Osswald
-
Patent number: 5389642Abstract: Novel imidazopyridine derivatives of the formula I ##STR1## in which R is ##STR2## and R.sup.1 to R.sup.4, X and Y are as defined herein, and their salts have antagonistic properties towards angiotensin(II) and can be used for the treatment of hypertension, aldosteronism, cardiac insufficiency and increased intraocular pressure and also disorders of the central nervous system.Type: GrantFiled: December 16, 1993Date of Patent: February 14, 1995Assignee: Merck Patent Gesellschaft Mit Beschrankter HaftungInventors: Dieter Dorsch, Werner Mederski, Mathias Osswald, Pierre Schelling, Norbert Beier, Ingeborg Lues, Klaus-Otto Minck
-
Patent number: 5371226Abstract: 2-oxoquinoline derivative of formula I; ##STR1## wherein R is ##STR2## and R.sup.1 to R.sup.6 and X are as defined in claim 1, and their salts exhibit antagonistic properties towards angiotensin II and have inter alia a hypotensive action.Type: GrantFiled: March 16, 1993Date of Patent: December 6, 1994Assignee: Merck Patent Gesellschaft Mit Beschrankter HaftungInventors: Werner Mederski, Dieter Dorsch, Norbert Beier, Ingeborg Lues, Klaus-Otto Minck, Pierre Schelling
-
Patent number: 5332750Abstract: New 1,2-dihydro-2-oxopyridines of formula I ##STR1## in which R is the radical ##STR2## and R.sup.1 to R.sup.6 and X are as defined herein,and their salts, have antagonistic properties towards angiotensin II and can be used for the treatment of hypertension, aldosteronism and cardiac insufficiency.Type: GrantFiled: April 22, 1993Date of Patent: July 26, 1994Assignee: Merck Patent Gesellschaft mit beschrankter HaftungInventors: Werner Mederski, Norbert Beier, Pierre Schelling, Ingeborg Lues, Klaus-Otto Minck
-
Patent number: 5242928Abstract: Novel imidazopyridine derivatives of formula I: ##STR1## wherein R is ##STR2## R.sup.1 is A, alkenyl or alkynyl each having up to 6 C atoms, R.sup.2 is H, COOH, COOA, CN, NO.sub.2, NHCOR.sup.5, NHSO.sub.2 R.sup.5 or 1H-tetrazol-5-yl,R.sup.3 is R.sup.5 --CO--alkyl, Ar--CO--alkyl, Het--CO--alkyl or Het-alkyl each having 1-6 C atoms in the alkyl moiety,R.sup.4 is H or Hal,R.sup.5 is alkyl having 1-6 C atoms, wherein one or more H atoms can also be replaced with F,X is absent or is --NH--CO--, --CO--NH--, --O--CH(COOH)--, --NH--CH(COOH)--, --NA--CH(COOH)--, --CH.dbd.C(COOH)--, --CH.dbd.C(CN)-- OR --CH.dbd.C(1H-tetrazol-t-yl)--,Y is O or S,A is alkyl having 1-6 C atoms,Ar is unsubstituted phenyl or phenyl monosubstituted by R.sup.5, OR.sup.5, COOH, COOA, CN, NO.sub.2, NH.sub.2, NHCOR.sup.5, NHSO.sub.2 R.sup.Type: GrantFiled: December 17, 1992Date of Patent: September 7, 1993Assignee: Merck Patent Gesellschaft mit beschrankter HaftungInventors: Werner Mederski, Dieter Dorsch, Norbert Beier, Pierre Schelling, Ingeborg Lues, Klaus-Otto Minck
-
Patent number: 5137885Abstract: Thiadiazinones of the formula I ##STR1## in which R.sup.1, R.sup.2, R.sup.3, R.sup.4 and R.sup.5 have the meaning given in claim 1, show positively inotropic and vasodilating action and are suitable for combating cardiovascular diseases.Type: GrantFiled: December 20, 1991Date of Patent: August 11, 1992Assignee: Merck Patent Gesellschaft Mit Beschraenkter HaftungInventors: Rochus Jonas, Ingeborg Lues, Norbert Beier, Michael Klockow, Klaus-Otto Minck