Patents by Inventor Norbert Dereu

Norbert Dereu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Farnesyl transferase inhibitors, their preparation, the pharmaceutical compositions which contain them and their use in the preparation of medicaments
    Patent number: 6218406
    Abstract: Novel products of formula (I), their preparation, the pharmaceutical compositions which contain them and their use in the preparation of medicaments.
    Type: Grant
    Filed: July 2, 1999
    Date of Patent: April 17, 2001
    Assignee: Aventis Pharma S.A.
    Inventors: Jean-Dominique Bourzat, Alain Commerçon, Norbert Dereu, Patrick Mailliet, Fabienne Sounigo-Thompson, Jean-Paul Martin, Marc Capet, Michel Cheve
  • 5,6,7,8 tetrahydroindolizines derivatives
    Patent number: 6194426
    Abstract: A novel therapeutic use of pyrrole derivatives of the folloeing formula: in which the variables are as defined in the specification and their salts thereof for treating conditions in which TNF is involved.
    Type: Grant
    Filed: December 12, 1997
    Date of Patent: February 27, 2001
    Assignee: Rhona-Poulenc Rorer S.A.
    Inventors: Eric Bacque, Conception Nemecek, Georges Bashiardes, Norbert Dereu
  • Farnesyl transferase inhibitors, their preparation, the pharmaceutical compositions which contain them and their use in the preparation of medicaments
    Patent number: 6124465
    Abstract: Novel products of formula (I), their preparation, the pharmaceutical compositions which contain them and their use in the preparation of medicaments. ##STR1## In the formula (I), the following substituents are among the preferred: Ar represents a substituted or condensed phenyl radical or a polycyclic or heterocyclic aromatic radical, R represents a radical of general formula --(CH.sub.2).sub.m --X.sub.1 --(CH.sub.2).sub.n --Z in which X.sub.1 =single bond, O, S; m=0, 1; n=0, 1, 2; it being possible for the CH.sub.2 radicals to be substituted; Z represents carboxyl, COOR.sub.6 (R.sub.6 =alkyl), CON(R.sub.7)(R.sub.8) (R.sub.7 =hydrogen or alkyl and R.sub.8 =hydrogen, hydroxyl, arylsulphonyl, heterocyclyl, optionally substituted amino, optionally substituted alkyloxy or optionally substituted alkyl), PO(OR.sub.9).sub.2 (R.sub.9 =hydrogen or alkyl), an --NH--CO--T (T=hydrogen or optionally substituted alkyl) radical, or else--a ##STR2## radical, R.sub.1 and R.sub.
    Type: Grant
    Filed: July 2, 1999
    Date of Patent: September 26, 2000
    Assignee: Rhone-Poulenc S.A.
    Inventors: Jean-Dominique Bourzat, Alain Commer.cedilla.on, Norbert Dereu, Patrick Mailliet, Fabienne Sounigo-Thompson, Jean-Paul Martin, Marc Capet, Michel Cheve
  • Farnesyl transferase inhibitors, their preparation, the pharmaceutical compositions which contain them and their use in the preparation of medicaments
    Patent number: 6013662
    Abstract: Novel products of formula (I), their preparation, the pharmaceutical compositions which contain them and their use in the preparation of medicaments. ##STR1## In the formula (I), the following substituents are among the preferred: Ar represents a substituted or condensed phenyl radical or a polycyclic or heterocyclic aromatic radical, R represents a radical of general formula --(CH.sub.2).sub.m --X.sub.1 --(CH.sub.2).sub.n --Z in which X.sub.1 =single bond, O, S; m=0, 1; n=0, 1, 2; it being possible for the CH.sub.2 radicals to be substituted; Z represents carboxyl, COOR.sub.6 (R.sub.6 =alkyl), CON(R.sub.7)(R.sub.8) (R.sub.7 =hydrogen or alkyl and R.sub.8 =hydrogen, hydroxyl, arylsulphonyl, heterocyclyl, optionally substituted amino, optionally substituted alkyloxy or optionally substituted alkyl), PO(OR.sub.9).sub.2 (R.sub.9 =hydrogen or alkyl), an --NH--CO--T (T=hydrogen or optionally substituted alkyl) radical, or elsea ##STR2## radical, R.sub.1 and R.sub.
    Type: Grant
    Filed: December 29, 1997
    Date of Patent: January 11, 2000
    Assignee: Rhone-Poulenc Rorer S.A.
    Inventors: Jean-Dominique Bourzat, Alain Commer.cedilla.on, Norbert Dereu, Patrick Mailliet, Fabienne Sounigo-Thompson, Jean-Paul Martin, Marc Capet, Michel Cheve
  • Substituted quinolyl compounds exhibiting selective leukotriene B.sub.4 antagonist activity
    Patent number: 5492915
    Abstract: This invention relates to compounds having selective LTB.sub.4 antagonist properties. Therapeutic compositions comprising said compounds and methods for the treatment of disorders involving LTB.sub.4 agonist-mediated activity utilizing said compositions wherein the compounds are described by the formula ##STR1## wherein R.sub.4, X, R, Y, R', Q, m and n are herein defined, and pharmaceutically acceptable salts thereof.
    Type: Grant
    Filed: October 6, 1994
    Date of Patent: February 20, 1996
    Assignee: Rhone-Poulenc Rorer S.A.
    Inventors: Norbert Dereu, Wolfram Hendel, Richard Labaudiniere
  • Lupane derivatives, their preparation and the pharmaceutical compositions which contain them
    Patent number: 5468888
    Abstract: The present invention relates to new lupane dervivatives of the general formula: ##STR1## to their salts, to their preparation and to the pharmaceutical compositions which contain them.
    Type: Grant
    Filed: May 12, 1994
    Date of Patent: November 21, 1995
    Assignee: Rhone-Poulenc Rorer S.A.
    Inventors: Romaine Bouboutou, Norbert Dereu, Michel Evers, Jean-Christophe Gueguen, Claude James, Christele Poujade, Daniel Reisdorf, Yves Ribeill, Francoise Soler
  • Substituted bicyclic bis-aryl compounds exhibiting selective leukotriene B.sub.4 antagonist activity, their preparation and use in pharmaceutical compositions
    Patent number: 5366982
    Abstract: This invention relates to compounds having selective LTB.sub.4 antagonist properties, compositions comprising said compounds and methods for the treatment of disorders involving LTB.sub.4 agonist-mediated activity utilizing said compositions wherein the compounds are described by the general formula ##STR1## and pharmaceutically acceptable salts thereof.
    Type: Grant
    Filed: February 17, 1993
    Date of Patent: November 22, 1994
    Assignee: Rhone-Poulenc Rorer S.A.
    Inventors: Norbert Dereu, Wolfram Hendel, Richard Labaudiniere
  • Anti-inflammatory picolyselenobenzamides and salts thereof
    Patent number: 5126357
    Abstract: A compound or a pharmaceutically acceptable salt thereof, having anti-inflammatory activity, is disclosed according to the Formula (I) ##STR1## wherein R is hydrogen, methyl or ethyl,R.sub.1 is a 2-pyridyl, 3-pyridyl or 4-pyridyl group or is phenyl, chlorophenyl or fluorophenyl,R.sub.2 is a 2-pyridyl, 3-pyridyl or 4-pyridyl group,R.sub.3 and R.sub.4 are identical or different and, taken separately, are hydrogen, fluorine, chlorine, bromine, C.sub.1 to C.sub.4 alkyl, C.sub.1 to C.sub.4 alkoxy, hydroxy, cyano or nitro or, taken together, are methylenedioxy, and n is 0 or 1.
    Type: Grant
    Filed: November 8, 1990
    Date of Patent: June 30, 1992
    Assignee: A. Nattermann & Cie. GmbH
    Inventors: Michel Evers, Michael Parnham, Axel Romer, Hartmut Fischer, Norbert Dereu
  • Diselenobis-benzoic acid amides of primary and secondary amines and processes for the treatment of diseases in humans caused by a cell injury
    Patent number: 4873350
    Abstract: The present invention relates to new diselenobis-benzoic acid amides of primary and secondary amines of the general formula (I): ##STR1## and processes for the treatment of diseases in humans caused by a cell injury.
    Type: Grant
    Filed: October 3, 1988
    Date of Patent: October 10, 1989
    Assignee: A Nattermann & CIE GmbH
    Inventors: Andre Welter, Harmut Fischer, Leon Christiaens, Albrecht Wendel, Eugen Etschenberg, Norbert Dereu, Peter Kuhl, Eric Graf
  • Benzisoselenazolonyl derivatives and processes for the treatment of rheumatic disease
    Patent number: 4774252
    Abstract: The present invention relates to new benzisoselenazolonyl derivatives of the general formula (I) ##STR1## and processes for the treatment of rheumatic diseases.
    Type: Grant
    Filed: February 17, 1988
    Date of Patent: September 27, 1988
    Assignee: A. Nattermann & Cie GmbH
    Inventors: Andre Welter, Christian Lambert, Norbert Dereu, Andrea Huther, Eugen Etschenberg
  • S-[2-phenyl (alkyl) carbamoyl]-phenylselenylmercapto derivatives
    Patent number: 4730053
    Abstract: The present invention is related to new S-(Carbamoyl-phenylselenyl) derivatives of mercaptanes of the general formula (I) ##STR1## and to a process for the treatment of diseases caused by cell injury due to the increased formation of active oxygen metabolites.
    Type: Grant
    Filed: November 25, 1985
    Date of Patent: March 8, 1988
    Assignee: A. Nattermann & Cie GmbH
    Inventors: Norbert Dereu, Albrecht Wendel, Helmut Sies, Sigurd Leyck, Axel Romer, Erich Graf
  • S-(carbamoyl-phenylselenyl) derivatives of glutathione and of aminomercaptocarboxylic acids
    Patent number: 4618669
    Abstract: The present invention relates to new S-(carbamoylphenylselenyl) derivatives of glutathione and of .alpha.
    Type: Grant
    Filed: June 14, 1985
    Date of Patent: October 21, 1986
    Assignee: A. Nattermann & Cie GmbH
    Inventors: Norbert Dereu, Andre Welter, Albrecht Wendel, Sigurd Leyck, Michael Parnham, Erich Graf, Helmut Sies, Hans Betzing, Hartmut Fischer