Patents by Inventor Norbert Hagen
Norbert Hagen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20230393163Abstract: Systems and methods for transferring containers (100) include or employ a container loading interface (200), a container storage module (400), and a container distributor (300) configured to transfer containers from the container loading interface to the container storage module. The container loading interface includes movable support platform (202) that is movable between accessible and a non-accessible positions and a container loading transport (214). The container storage module includes a housing (402) and a container storage transport (418). The container distributor includes a container gripper (320) configured to grasp a container on the container loading transport and to transfer the container to the container storage transport in the container storage module.Type: ApplicationFiled: October 21, 2021Publication date: December 7, 2023Inventors: David A. BUSE, Norbert HAGEN, David OPALSKY
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Publication number: 20230358682Abstract: An apparatus for detecting an optical signal emission includes signal transmission fibers. Each fiber includes cores having the same spatial core arrangement at each end. The first ends are configured to be optically coupled to the signal emission sources. Each fiber is configured to transmit an optical signal between the first end and the second. The apparatus can also include a frame assembly securing the first ends of the fibers in a first spatial fiber arrangement corresponding to a spatial arrangement of the signal emission sources. The frame assembly can also secure the second ends of the fibers in a second spatial fiber arrangement different from the first spatial fiber arrangement. The apparatus can also include at least one signal detector configured to be optically coupled to the second ends of the fibers and configured to detect an optical signal emitted by each signal emission source.Type: ApplicationFiled: January 25, 2023Publication date: November 9, 2023Inventors: Norbert HAGEN, George WALKER, David COMBS
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Patent number: 11585760Abstract: An apparatus for detecting an optical signal emissions includes signal transmission fibers. Each fiber includes cores having the same spatial core arrangement at each end. The first ends are configured to be optically coupled to the signal emission sources. Each fiber is configured to transmit an optical signal between the first end and the second. The apparatus can also include a frame assembly securing the first ends of the fibers in a first spatial fiber arrangement corresponding to a spatial arrangement of the signal emission sources. The frame assembly can also secure the second ends of the fibers in a second spatial fiber arrangement different from the first spatial fiber arrangement. The apparatus can also include at least one signal detector configured to be optically coupled to the second ends of the fibers, and configured to detect an optical signal emitted by each signal emission source.Type: GrantFiled: July 25, 2018Date of Patent: February 21, 2023Assignee: GEN-PROBE INCORPORATEDInventors: Norbert Hagen, George Walker, II, David Combs
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Publication number: 20200217794Abstract: An apparatus for detecting an optical signal emissions includes signal transmission fibers. Each fiber includes cores having the same spatial core arrangement at each end. The first ends are configured to be optically coupled to the signal emission sources. Each fiber is configured to transmit an optical signal between the first end and the second. The apparatus can also include a frame assembly securing the first ends of the fibers in a first spatial fiber arrangement corresponding to a spatial arrangement of the signal emission sources. The frame assembly can also secure the second ends of the fibers in a second spatial fiber arrangement different from the first spatial fiber arrangement. The apparatus can also include at least one signal detector configured to be optically coupled to the second ends of the fibers, and configured to detect an optical signal emitted by each signal emission source.Type: ApplicationFiled: July 25, 2018Publication date: July 9, 2020Inventors: Norbert HAGEN, George WALKER, David COMBS
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Patent number: 8426209Abstract: Apparatus and Methods are provided for a microfabricated fluorescence activated cell sorter based on an optical switch for rapid, active control of cell routing through a microfluidic channel network. This sorter enables low-stress, highly efficient sorting of populations of small numbers of cells (i.e., 1000-100,000 cells). The invention includes packaging of the microfluidic channel network in a self-contained plastic cartridge that enables microfluidic channel network to macro-scale instrument interconnect, in a sterile, disposable format.Type: GrantFiled: June 28, 2010Date of Patent: April 23, 2013Assignee: Celula, Inc.Inventors: William Frank Butler, Mirianas Chachisvilis, Robert Dees, Norbert Hagen, Philippe Marchand, Daniel E. Raymond, Eugene Tu, Mark M. Wang, Joon Mo Yang, Rong Yang, Haichuan Zhang
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Publication number: 20100304429Abstract: Apparatus and Methods are provided for a microfabricated fluorescence activated cell sorter based on an optical switch for rapid, active control of cell routing through a microfluidic channel network. This sorter enables low-stress, highly efficient sorting of populations of small numbers of cells (i.e., 1000-100,000 cells). The invention includes packaging of the microfluidic channel network in a self-contained plastic cartridge that enables microfluidic channel network to macro-scale instrument interconnect, in a sterile, disposable format.Type: ApplicationFiled: June 28, 2010Publication date: December 2, 2010Inventors: William Frank Butler, Mirianas Chachisvilis, Robert Dees, Norbert Hagen, Philippe Marchand, Daniel E. Raymond, Eugene Tu, Mark M. Wang, Joon Mo Yang, Rong Yang, Haichuan Zhang
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Patent number: 7745221Abstract: Apparatus and Methods are provided for a microfabricated fluorescence activated cell sorter based on an optical switch for rapid, active control of cell routing through a microfluidic channel network. This sorter enables low-stress, highly efficient sorting of populations of small numbers of cells (i.e., 1000-100,000 cells). The invention includes packaging of the microfluidic channel network in a self-contained plastic cartridge that enables microfluidic channel network to macro-scale instrument interconnect, in a sterile, disposable format.Type: GrantFiled: August 27, 2004Date of Patent: June 29, 2010Assignee: Celula, Inc.Inventors: William Frank Butler, Mirianas Chachisvilis, Robert Dees, Norbert Hagen, Philippe Marchand, Daniel E. Raymond, Eugene Tu, Mark M. Wang, Joon Mo Yang, Rong Yang, Haichuan Zhang
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Patent number: 7148966Abstract: Systems and methods for automated laser capture microdissection are disclosed. High throughput microdissection is provided by using cell procurement and multi-imaging tools for pre-selecting cells of interest. Novel methods of computer-controlled cap transfer along with automated multi-slide and multi-cap placements, and automated slide and cap detection are provided. The systems and methods provide the advantages of increased speed and much lower rates of contamination.Type: GrantFiled: January 13, 2006Date of Patent: December 12, 2006Assignee: Arcturus Bioscience, Inc.Inventors: Thomas M. Baer, Norbert Hagen, Bruce J. Richardson, David R. Brewer, III, Lisa Reese
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Publication number: 20060114456Abstract: Systems and methods for automated laser capture microdissection are disclosed. High throughput microdissection is provided by using cell procurement and multi-imaging tools for pre-selecting cells of interest. Novel methods of computer-controlled cap transfer along with automated multi-slide and multi-cap placements, and automated slide and cap detection are provided. The systems and methods provide the advantages of increased speed and much lower rates of contamination.Type: ApplicationFiled: January 13, 2006Publication date: June 1, 2006Inventors: Thomas Baer, Norbert Hagen, Bruce Richardson, David Brewer, Lisa Reese
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Patent number: 7027133Abstract: Systems and methods for automated laser capture microdissection are disclosed. High throughput microdissection is provided by using cell procurement and multi-imaging tools for pre-selecting cells of interest. Novel methods of computer-controlled cap transfer along with automated multi-slide and multi-cap placements, and automated slide and cap detection are provided. The systems and methods provide the advantages of increased speed and much lower rates of contamination.Type: GrantFiled: November 15, 2004Date of Patent: April 11, 2006Assignee: Arcturus Bioscience, Inc.Inventors: Thomas M. Baer, Norbert Hagen, Bruce J. Richardson, David R. Brewer, III, Lisa Reese
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Publication number: 20050207940Abstract: Apparatus and Methods are provided for a microfabricated fluorescence activated cell sorter based on an optical switch for rapid, active control of cell routing through a microfluidic channel network. This sorter enables low-stress, highly efficient sorting of populations of small numbers of cells (i.e., 1000-100,000 cells). The invention includes packaging of the microfluidic channel network in a self-contained plastic cartridge that enables microfluidic channel network to macro-scale instrument interconnect, in a sterile, disposable format.Type: ApplicationFiled: August 27, 2004Publication date: September 22, 2005Inventors: William Butler, Mirianas Chachisvilis, Robert Dees, Norbert Hagen, Philippe Marchand, Daniel Raymond, Eugene Tu, Mark Wang, Joon Yang, Rong Yang, Haichuan Zhang
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Publication number: 20050089949Abstract: Systems and methods for automated laser capture microdissection are disclosed. High throughput microdissection is provided by using cell procurement and multi-imaging tools for pre-selecting cells of interest. Novel methods of computer-controlled cap transfer along with automated multi-slide and multi-cap placements, and automated slide and cap detection are provided. The systems and methods provide the advantages of increased speed and much lower rates of contamination.Type: ApplicationFiled: November 15, 2004Publication date: April 28, 2005Inventors: Thomas Baer, Norbert Hagen, Bruce Richardson, David Brewer, Lisa Reese
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Patent number: 6870625Abstract: Systems and methods for automated laser capture microdissection are disclosed. High throughput microdissection is provided by using cell procurement and multi-imaging tools for pre-selecting cells of interest. Novel methods of computer-controlled cap transfer along with automated multi-slide and multi-cap placements, and automated slide and cap detection are provided. The systems and methods provide the advantages of increased speed and much lower rates of contamination.Type: GrantFiled: December 12, 2003Date of Patent: March 22, 2005Assignee: Arcturus Bioscience, Inc.Inventors: Thomas M. Baer, Norbert Hagen, Bruce J. Richardson, David R. Brewer, III, Lisa Reese
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Publication number: 20040158226Abstract: A syringe tissue sieve for producing viable, single cell suspensions includes a syringe barrel having a lumen between a proximal end and a distal end thereof, a wire mesh screen disposed within the lumen of the syringe barrel, the wire mesh screen being oriented perpendicular to the axial direction of the lumen, and a plunger moveable within the lumen of the syringe barrel. In an alternative embodiment, the wire mesh screen is located in a collar assembly which can be loaded into off-the-shelf syringes.Type: ApplicationFiled: February 7, 2003Publication date: August 12, 2004Applicant: Genoptix, Inc.Inventors: William Soo Hoo, Norbert Hagen, Brad Styer, Eugene Tu
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Publication number: 20040067167Abstract: A device for characterizing a cell or particle includes a channel having an inlet and an outlet, the channel containing a moving fluid therein for carrying the cell or particle from the inlet to the outlet. The device includes a detector for detecting the presence of a cell or particle along portion of the channel, the detector including a first detecting position, a second detecting position, and a third detecting position. The device further includes a light source providing an optical gradient disposed within the channel and between the second and third detecting positions. A control system is coupled to the detector to receive and process detected signals from the detector. During operation, the amount of time that a cell or particle takes to flow through a first distance (i.e., its time-of-flight) is measured. The cell or particle is then flowed past a second, downstream distance in the presence of an optical gradient and its time-of-flight is measured.Type: ApplicationFiled: October 8, 2002Publication date: April 8, 2004Applicant: Genoptix, Inc.Inventors: Haichuan Zhang, Thomas D.Y. Chung, Jeff Hall, William SooHoo, Josh Kohrumel, Eugene Tu, Mark Wang, Daniel Edward Raymond, Philippe Marchand, Jonathan Diver, William F. Butler, Phan Nguyen, Mirianas Chachisvilis, Andrew S. Katz, Norbert Hagen, Kris Lykstad, Luis Pestana
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Patent number: 6690470Abstract: Systems and methods for automated laser capture microdissection are disclosed. High throughput microdissection is provided by using cell procurement and multi-imaging tools for pre-selecting cells of interest. Novel methods of computer-controlled cap transfer along with automated multi-slide and multi-cap placements, automated slide and cap detection are provided. The systems and methods provide the advantages of increased speed and much lower rates of contamination.Type: GrantFiled: November 6, 2000Date of Patent: February 10, 2004Assignee: Arcturus Engineering, Inc.Inventors: Thomas M. Baer, Norbert Hagen, Bruce J. Richardson, David R. Brewer, III, Lisa Reese
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Publication number: 20020090122Abstract: Systems and methods for capturing and using a road map image for guiding microscopy and microdissection are disclosed. Systems for using a static reference road map image for navigation and analysis of a live image of a sample are provided. A road map camera for capturing a low resolution reference image of the sample is disclosed. Novel methods for computer-controlled navigation of the road map image are provided.Type: ApplicationFiled: November 5, 2001Publication date: July 11, 2002Inventors: Thomas M. Baer, Norbert Hagen, Bruce J. Richardson, David R. Brewer, Lisa Reese