Abstract: The invention relates to a roll take-up device (110) designed for • a) taking up a sheetlike composite (101), and • b) rolling up or unrolling or both rolling up and unrolling a roll (102) of the sheetlike composite (101); • i) a carrier layer (304), • ii) a barrier layer (306) and • iii) an inner polymer layer (308); wherein, in the roll (102), at least 10 laminas of the sheetlike composite (101) are overlaid on one another from the inside outwards or vice versa; wherein the laminas respectively have the series of layers (304, 306, 308); wherein one layer (306) of the series of layers of the sheetlike composite (101) is an electrically conductive layer.

Abstract: The invention relates to a roll take-up device (110) designed for ?a) taking up a sheetlike composite (101), and ?b) rolling up or unrolling or both rolling up and unrolling a roll (102) of the sheetlike composite (101); ?i) a carrier layer (304), ?ii) a barrier layer (306) and ?iii) an inner polymer layer (308); wherein, in the roll (102), at least 10 laminas of the sheetlike composite (101) are overlaid on one another from the inside outwards or vice versa; wherein the laminas respectively have the series of layers (304, 306, 308); wherein one layer (306) of the series of layers of the sheetlike composite (101) is an electrically conductive layer;

Abstract: The present invention includes composition and methods for making and using a combinatorial library having two or more beads, wherein attached to each bead is a unique nucleic acid aptamer that have disposed thereon a unique sequence. The library aptamers may be attached covalently to the one or more beads, which may be polystyrene beads. The aptamers may include phosphorothioate, phosphorodithioate and/or methylphosphonate linkages and may be single or double stranded DNA, RNA or even PNAs.

Abstract: The present invention includes composition and methods for making and using a combinatorial library having two or more beads, wherein attached to each bead is a unique nucleic acid aptamer that have disposed thereon a unique sequence. The library aptamers may be attached covalently to the one or more beads, which may be polystyrene beads. The aptamers may include phosphorothioate, phosphorodithioate and/or methylphosphonate linkages and may be single or double stranded DNA, RNA or even PNAs.

Abstract: The present invention includes composition and methods for making and using a combinatorial library having two or more beads, wherein attached to each bead is a unique nucleic acid aptamer that have disposed thereon a unique sequence. The library aptamers may be attached covalently to the one or more beads, which may be polystyrene beads. The aptamers may include phosphorothioate, phosphorodithioate and/or methylphosphonate linkages and may be single or double stranded DNA, RNA or even PNAs.

Abstract: The present invention includes composition and methods for making and using a combinatorial library having two or more beads, wherein attached to each bead is a unique nucleic acid aptamer that have disposed thereon a unique sequence. The library aptamers may be attached covalently to the one or more beads, which may be polystyrene beads. The aptamers may include phosphorothioate, phosphorodithioate and/or methylphosphonate linkages and may be single or double stranded DNA, RNA or even PNAs.

Abstract: The present invention provides a method for concurrent achiral nucleotide modification and amplification using PCR. Provided by this method are NF-kB specific thioaptamers of novel sequence. This invention further provides methods of post-selection aptamer modification wherein one or more selected nucleotides of aptamers of known sequence are substituted with modified achiral nucleotides, particularly achiral thiophosphate nucleotides, wherein the substitution results in increased nuclease resistance while retaining binding efficiency and selectivity. Thiosubstitution of post-selection aptamers with specificity for the nuclear factor, NF-?B, produced in accordance with this method have increased binding affinity and specificity in addition to nuclease resistance. Also provided are methods for fractionating oligonucleotides depending on their degree of thiosubstitution by anion exchange chromatography.

Abstract: The present invention includes composition and methods for making and using a combinatorial library having two or more beads, wherein attached to each bead is a unique nucleic acid aptamer that have disposed thereon a unique sequence. The library aptamers may be attached covalently to the one or more beads, which may be polystyrene beads. The aptamers may include phosphorothioate, phosphorodithioate and/or methylphosphonate linkages and may be single or double stranded DNA, RNA or even PNAs.

Abstract: This invention generally relates the generation of aptamers and to the use of aptamers as diagnostic and therapeutic agents. More particularly, the present invention relates to methods using combinatorial chemistry to prepare aptamers having controlled thiophosphate replacement in the phosphate backbone for improved binding efficiencies to a target and to RNA and/or DNA products having novel nucleotide sequences and enhanced target binding efficacies.

Abstract: An apparatus and method for monitoring biological interactions is disclosed. The apparatus includes a substrate, a modified nucleotide aptamer attached to the substrate, a target molecule or portion thereof, wherein the interaction between the modified nucleotide aptamer and the target molecule or portion thereof is detected.

Abstract: A medical system architecture include at least one modality for acquiring medical images, an apparatus for processing the medical images and for accepting patient-related data, an apparatus for communicating the images and data, and an apparatus for storing the images and patient-related data. Furthermore, an apparatus for the digital acquisition of optical images, such as a photo camera, a video camera and/or a scanner, is connected to the apparatus for communication, it being possible to store the digitized optical images in the apparatus together with the medical images and patient-related data.