Abstract: The present invention relates to a method for identifying a pharmaceutically active compound that modulates the rpL35 (rpL35/rpL29)-dependent translation of at least one mRNA in a mammalian cell. The mRNA may comprise a premature termination codon (PTC), undergoes premature translation termination, causes programmed ?1 ribosomal frame shifting (?1PRF), or is a polycistronic mRNA. Furthermore a respective screening system, methods of treating or preventing a disease or condition, and compounds that modulate the rpL35 (rpL35/rpL29)-dependent translation, in particular atazanavir or derivatives thereof and artemisinin or artesunate or derivatives thereof are provided.

Abstract: The invention relates to a sulfur-crosslinkable rubber mixture, a vulcanizate and a vehicle tire. The sulfur-crosslinkable rubber mixture contains at least the following constituents: at least one diene rubber and at least one silica and at least one silane having the general empirical formula [(R1)oSi—(R3—)pX—(R4—)p]mSn(R2)2-m,??I) where X is a radical comprising at least one polar group selected from urethane, amide, ester, amine, thiourea, thioamide, O-organyl thiocarbamate, S-organyl thiocarbamate, amidine, guanidine, piperidine, maleic anhydride, sulfonamide, carbonate, imidazoline, thiazolidine, thiazolidinone, pyrrolidine, pyrazole, benzimidazole, indole, purine, thiazine, sulfonate, and phosphonate groups.

Abstract: The invention relates to a sulfur-crosslinkable rubber mixture, a vulcanizate and a vehicle tire. The sulfur-crosslinkable rubber mixture contains at least the following constituents: at least one diene rubber and at least one silica and at least one silane having the general empirical formula [(R1)oSi—(R3—)pX—(R4—)p]mSn(R2)2-m,??I) where X is a radical comprising at least one polar group selected from urethane, amide, ester, amine, thiourea, thioamide, O-organyl thiocarbamate, S-organyl thiocarbamate, amidine, guanidine, piperidine, maleic anhydride, sulfonamide, carbonate, imidazoline, thiazolidine, thiazolidinone, pyrrolidine, pyrazole, benzimidazole, indole, purine, thiazine, sulfonate, and phosphonate groups.

Abstract: A pneumatic vehicle tire in radial design that is a summer tire or all-season tire, with a profiled tread comprising rows of profile blocks and/or profile ribs running around the tire in circumferential direction, wherein the total number of sipes within each row of profile blocks and/or profile ribs is not more than 150, wherein the tread is in the form of a single layer or multiple layers with a radially outermost tread layer that extends at least over the width of the ground contact area, and wherein the profile depth of the tread is up to 6.5 mm. The tread or its radially outermost tread layer consists of a rubber material with a Shore A hardness at room temperature in accordance with DIN ISO 7619-1 of 40 ShA to 55 ShA.

Abstract: The present disclosure relates to biosynthetic pathways for producing flavor and fragrance chemicals, such as green notes including trans-2-unsaturated aldehydes and lactones. The present disclosure provides methods for producing trans-2-unsaturated aldehydes, delta-lactones, and gamma-lactones. The present disclosure provides pathways for the preparation of trans-2-unsaturated aldehydes, delta-lactones, and gamma-lactones by reacting aldehydes in the presence of aldolases.

Abstract: The present invention relates to a novel catalytic hydrogenation of substituted 2-methyl cyanopyridyl derivatives, in particular 3-chloro-5-(trifluoromethyl)pyridin-2-yl]acetonitrile [=Py-CN] to substituted 2-ethylaminopyridine derivatives, in particular 2-[3-chloro-5-(trifluoromethyl)pyridin-2-yl]ethanamine [=Py-ethanamine] or salts thereof in the presence of metal catalysts, in particular palladium catalysts.

Abstract: The present disclosure relates to biosynthetic pathways for producing flavor and fragrance chemicals, such as green notes including trans-2-unsaturated aldehydes and lactones. The present disclosure provides methods for producing trans-2-unsaturated aldehydes, delta-lactones, and gamma-lactones. The present disclosure provides pathways for the preparation of trans-2-unsaturated aldehydes, delta-lactones, and gamma-lactones by reacting aldehydes in the presence of aldolases.

Abstract: The invention relates to a sulfur-crosslinkable rubber mixture, in particular for treads of vehicle tires, and to a vehicle tire. The rubber mixture contains at least the following components: at least one diene rubber and 10 to 200 phr of at least one silicic acid and 2 to 20 phf of at least one silane having general empirical formula I) [(R1)3Si—X]mSn(R2)2-m, wherein the residues R1 within a molecule can be the same or different and are alkoxy groups having 1 to 10 carbon atoms or cyclic dialkoxy groups having 2 to 10 carbon atoms or cycloalkoxy groups having 4 to 10 carbon atoms or phenoxy groups or aryl groups having 6 to 20 carbon atoms or alkyl groups having 1 to 10 carbon atoms or alkenyl groups having 2 to 20 carbon atoms or aralkyl groups having 7 to 20 carbon atoms or halides and wherein X is a polar organic group containing urea and wherein m assumes the value 1 or 2 and wherein n is an integer from 1 to 8 and wherein R2 is a hydrogen atom or an acyl group having 1 to 20 carbon atoms.

Abstract: An electromagnetic device includes discrete wires for its poles or teeth. In another aspect, an electromagnetic device includes a stator unit and an adjacent movable unit, at least one of which includes magnetic flux-carrying poles, with a majority of each pole including multiple discrete wires. In another aspect, the movable unit is an electric motor rotor, a linear electric motor armature, a solenoid armature, or an electric generator rotor.

Abstract: The present invention relates to a novel catalytic hydrogenation of substituted 2-methyl cyanopyridyl derivatives, in particular 3-chloro-5-(trifluoromethyl)pyridin-2-yl]acetonitrile [=Py-CN] to substituted 2-ethylaminopyridine derivatives, in particular 2-[3-chloro-5-(trifluoromethyl)pyridin-2-yl]ethanamine [=Py-ethanamine] or salts thereof in the presence of metal catalysts, in particular palladium catalysts.

Abstract: A wave disc engine apparatus is provided. A further aspect employs a constricted nozzle in a wave rotor channel. A further aspect provides a sharp bend between an inlet and an outlet in a fluid pathway of a wave rotor, with the bend being spaced away from a peripheral edge of the wave rotor. A radial wave rotor for generating electricity in an automotive vehicle is disclosed in yet another aspect.

Abstract: The invention relates to a sulfur-crosslinkable rubber mixture, in particular for treads of vehicle tires, and to a vehicle tire. The rubber mixture contains at least the following components: at least one diene rubber and 10 to 200 phr of at least one silicic acid and 2 to 20 phf of at least one silane having general empirical formula I) [(R1)3Si—X]mSn(R2)2-m, wherein the residues R1 within a molecule can be the same or different and are alkoxy groups having 1 to 10 carbon atoms or cyclic dialkoxy groups having 2 to 10 carbon atoms or cycloalkoxy groups having 4 to 10 carbon atoms or phenoxy groups or aryl groups having 6 to 20 carbon atoms or alkyl groups having 1 to 10 carbon atoms or alkenyl groups having 2 to 20 carbon atoms or aralkyl groups having 7 to 20 carbon atoms or halides and wherein X is a polar organic group containing urea and wherein m assumes the value 1 or 2 and wherein n is an integer from 1 to 8 and wherein R2 is a hydrogen atom or an acyl group having 1 to 20 carbon atoms.

Abstract: In the case of a variable-pitch propeller or repeller according to the invention, the pitch-adjusting device is arranged in the hub and formed in such a way that it allows only a numerically limited number of different blade pitches, preferably just two blade pitches, for which purpose the pitch-adjusting device comprises an electrical drive device, for moving the blades from a first blade pitch to a second of the numerically limited number of blade pitches, and an electrically actuable locking device, for locking the blades in the numerically limited number of different blade pitches.

Abstract: The present invention relates to a process for preparing N-(5-chloro-2-isopropylbenzyl)cyclopropanamine by hydrogenation of N-[(5-chloro-2-isopropylphenyl)methylene]cyclopropanamine over specific platinum catalysts.

Abstract: The present invention relates to a process for the preparation of substituted N-(benzyl)cyclopropanamines of the general formula (II) starting from N-[(aryl)methylene]cyclopropanamine derivatives. The present invention further provides the N-[(aryl)methylene]cyclopropanamine derivatives used as starting compounds in this process according to the invention, and their use for the preparation of substituted N (benzyl)cyclopropanamines.

Abstract: A motor vehicle steering wheel with at least one gripping portion for gripping the steering wheel by a driver and with a central steering wheel region which is connected with the gripping portion is provided. The central steering wheel region—based on the state of the steering wheel properly mounted in a motor vehicle—forms a cover surface facing the driver, wherein behind the cover surface a receptacle for a gas bag is arranged and the cover surface defines an outlet opening through which the gas bag can be deployed for the protection of the driver. The steering wheel furthermore comprises an electronic display device with a screen. The screen is provided beside the outlet opening on the cover surface of the central steering wheel region, and the surface of the screen amounts to at least 60% of the opening cross-section of the outlet opening.

Abstract: The present invention relates to a process for preparing 2-amino-5-cyano-N,3-dimethylbenzamide of formula (I) by reacting 2-amino-5-cyano-3-methylbenzoic esters or diesters with methylamine.

Abstract: The present invention relates to a process for preparing N-(5-chloro-2-isopropylbenzyl)cyclopropanamine by hydrogenation of N-[(5-chloro-2-isopropylphenyl)methylene]cyclopropanamine over specific platinum catalysts.

Abstract: Process for preparing 2,2-difluoroethanol, comprising the following steps: reacting 1-chloro-2,2-difluoroethane with an alkali metal salt of formic acid or acetic acid in a suitable solvent to give the corresponding 2,2-difluoroethyl formate or 2,2-difluoroethyl acetate, and transesterifying the 2,2-difluoroethyl formate or 2,2-difluoroethyl acetate from step (i) in the presence of an alcohol and optionally of a base.

Abstract: A wave rotor apparatus is provided. In another aspect of the present invention, a radial wave rotor includes fluid passageways oriented in a direction offset from its rotational axis. A further aspect of the present invention employs stacked layers of generally radial channels in a wave rotor. Moreover, turbomachinery is located internal to a wave rotor in yet another aspect of the present invention. In yet another aspect of the present invention, a radial wave rotor has an igniter and fuel injector. Correctional passages are employed in still another aspect of the present invention wave rotor.