Patents by Inventor Norbert Oranth
Norbert Oranth has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11045767Abstract: A micro fluid filtration system (100) preferably for increasing the concentration of components contained in a fluid sample has a fluid circuitry (1). The fluid circuitry (1) comprises the following elements: A tangential flow filtration element (7) capable for separating the fluid sample into a retentate stream and a permeate stream upon passage of the fluid, an element for pumping (3) for creating and driving a fluid flow through the fluid circuitry (1) and at least one element for obtaining information about the properties of the fluid sample within the circuitry. The circuitry further comprises a plurality of conduits (24) connecting the elements of the fluid circuitry (1) through which a fluid stream of the fluid sample is conducted. The circuitry (1) has a minimal working volume of at most 5 ml, which is the minimal fluid volume retained in the elements and the conduits (24) of the circuitry (1) such that the fluid can be recirculated in the circuitry (1) without pumping air through the circuitry (1).Type: GrantFiled: April 25, 2018Date of Patent: June 29, 2021Assignee: Hoffmann-La Roche Inc.Inventors: Norbert Oranth, Nadine Losleben, Sascha Lutz, Adelbert Grossmann
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Patent number: 10864519Abstract: A method of dispensing a particle mixture and a reagent fluid cartridge are presented. The cartridge comprises a first reservoir partially filled with reagent fluid, a second reservoir partially filled with particles, a pumping chamber, a first pumping chamber conduit connecting the first reservoir and the pumping chamber, a second pumping chamber conduit connecting the second reservoir and the pumping chamber, an outlet for dispensing reagent fluid and particles from the cartridge, an outlet conduit connecting the outlet to the pumping chamber, and a valve sealing the outlet conduit. The method comprises closing the valve, applying a force to the plunger to transport a first defined volume of reagent fluid and second defined volume of particles into the pumping chamber to form a mixture of reagent fluid and particles, opening the valve, and forcing the mixture from the pumping chamber using the plunger to dispense the mixture from the outlet.Type: GrantFiled: November 21, 2017Date of Patent: December 15, 2020Assignee: Roche Diagnostics Operations, Inc.Inventors: Thorsten Brueckner, Nadine Losleben, Norbert Oranth
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Publication number: 20200149578Abstract: A micro fluid filtration system (100) preferably for increasing the concentration of components contained in a fluid sample has a fluid circuitry (1). The fluid circuitry (1) comprises the following elements: A tangential flow filtration element (7) capable for separating the fluid sample into a retentate stream and a permeate stream upon passage of the fluid, an element for pumping (3) for creating and driving a fluid flow through the fluid circuitry (1) and at least one element for obtaining information about the properties of the fluid sample within the circuitry. The circuitry further comprises a plurality of conduits (24) connecting the elements of the fluid circuitry (1) through which a fluid stream of the fluid sample is conducted. The circuitry (1) has a minimal working volume of at most 5 ml, which is the minimal fluid volume retained in the elements and the conduits (24) of the circuitry (1) such that the fluid can be recirculated in the circuitry (1) without pumping air through the circuitry (1).Type: ApplicationFiled: April 25, 2018Publication date: May 14, 2020Inventors: Norbert Oranth, Nadine Losleben, Sascha Lutz, Adelbert Grossmann
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Patent number: 10509049Abstract: A method of operating a laboratory sample distribution system is presented. The method comprises a number of sample container carriers on a transport plane by a number of electro-magnetic actuators. The method is adapted to compensate deviations regarding physical properties of the sample container carriers, the transport plane and the electro-magnetic actuators compared to reference components. A laboratory automation system comprising such a laboratory sample distribution system is also presented.Type: GrantFiled: March 10, 2017Date of Patent: December 17, 2019Assignee: Roche Diagnostics Operations, Inc.Inventors: Achim Sinz, Christian Riether, Norbert Oranth, Martin Burri
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Patent number: 10330693Abstract: A cartridge for dispensing fluid is presented. The cartridge comprises a valve. The valve comprises a pumping chamber for pumping the fluid. The valve positions a pumping chamber conduit. The pumping chamber conduit is connected to the pumping chamber. The cartridge further comprises a plunger for changing the volume of the pumping chamber. The cartridge further comprises a reservoir conduit for connecting the reservoir with the valve. The valve positions the pumping chamber conduit to connect with the reservoir conduit. The cartridge further comprises an outlet conduit for dispensing the fluid. The valve further rotates the pumping chamber conduit to connect with the outlet conduit.Type: GrantFiled: April 19, 2016Date of Patent: June 25, 2019Assignee: Roche Diagnostics Operations, Inc.Inventors: Christoph Boehm, Peter Kupser, Norbert Oranth, Juergen Spinke, Thorsten Brueckner, Timo Klein
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Patent number: 10288609Abstract: A method for determining the amount of a specific analyte by photometric assays, wherein the specific analyte in a sample reacts with an analyte specific reaction partner in a reaction mixture. At least two calibration curves are generated, the first calibration curve recorded at a first wavelength is optimized for low concentrations of the specific analyte thereby maximizing the lower detection limit and, the second calibration curve recorded at a second wavelength is optimized for high concentrations of the specific analyte thereby maximizing the upper detection limit. The optimized lower detection limit and the optimized upper detection limit results in an extended dynamic range.Type: GrantFiled: April 12, 2018Date of Patent: May 14, 2019Assignee: ROCHE DIAGNOSTICS OPERATIONS, INC.Inventors: Thorsten Brueckner, Eloisa Lopez-Calle, Norbert Oranth, Josef Roedl
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Patent number: 10213742Abstract: A micro flow filtration system comprises a fluid circuitry (3) and a first reservoir (1) outside the circuitry (3) suitable for containing a fluid. The fluid circuitry (3) comprises a tangential flow filtration module (10) capable of separating the fluid sample into a retentate stream and a permeate stream upon passage of the fluid sample into the tangential flow filtration module (10) through an inlet feed (18). The fluid circuitry (3) further comprises a second reservoir (2) integrated in the fluid circuitry (3), a pump (5) for creating and driving a fluid flow, optionally at least one pressure sensor (6, 7 or 8) for acquiring and detecting data about the fluid sample, optionally a pressure regulator (9) for regulating the flow in the fluid circuitry (3) and a plurality of conduits (22) forming the fluid circuitry (3) together with the second reservoir (2), the TFF-module (10), the pump (5), the pressure sensor (6, 7 or 8) (if present) and the pressure regulator (9) (if present).Type: GrantFiled: March 25, 2013Date of Patent: February 26, 2019Assignee: Hoffmann-La Roche, Inc.Inventors: Norbert Oranth, Nadine Losleben, Sascha Lutz, Adelbert Grossmann
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Publication number: 20180245619Abstract: A micro fluid filtration system (100) preferably for increasing the concentration of components contained in a fluid sample has a fluid circuitry (1). The fluid circuitry (1) comprises the following elements: A tangential flow filtration element (7) capable for separating the fluid sample into a retentate stream and a permeate stream upon passage of the fluid, an element for pumping (3) for creating and driving a fluid flow through the fluid circuitry (1) and at least one element for obtaining information about the properties of the fluid sample within the circuitry. The circuitry further comprises a plurality of conduits (24) connecting the elements of the fluid circuitry (1) through which a fluid stream of the fluid sample is conducted. The circuitry (1) has a minimal working volume of at most 5 ml, which is the minimal fluid volume retained in the elements and the conduits (24) of the circuitry (1) such that the fluid can be recirculated in the circuitry (1) without pumping air through the circuitry (1).Type: ApplicationFiled: April 25, 2018Publication date: August 30, 2018Inventors: Norbert Oranth, Nadine Losleben, Sascha Lutz, Adelbert Grossmann
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Publication number: 20180231544Abstract: A method for determining the amount of a specific analyte by photometric assays, wherein the specific analyte in a sample reacts with an analyte specific reaction partner in a reaction mixture. At least two calibration curves are generated, the first calibration curve recorded at a first wavelength is optimized for low concentrations of the specific analyte thereby maximizing the lower detection limit and, the second calibration curve recorded at a second wavelength is optimized for high concentrations of the specific analyte thereby maximizing the upper detection limit. The optimized lower detection limit and the optimized upper detection limit results in an extended dynamic range.Type: ApplicationFiled: April 12, 2018Publication date: August 16, 2018Applicant: Roche Diagnostics Operations, Inc.Inventors: Thorsten Brueckner, Eloisa Lopez-Calle, Norbert Oranth, Josef Roedl
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Publication number: 20180071740Abstract: A method of dispensing a particle mixture and a reagent fluid cartridge are presented. The cartridge comprises a first reservoir partially filled with reagent fluid, a second reservoir partially filled with particles, a pumping chamber, a first pumping chamber conduit connecting the first reservoir and the pumping chamber, a second pumping chamber conduit connecting the second reservoir and the pumping chamber, an outlet for dispensing reagent fluid and particles from the cartridge, an outlet conduit connecting the outlet to the pumping chamber, and a valve sealing the outlet conduit. The method comprises closing the valve, applying a force to the plunger to transport a first defined volume of reagent fluid and second defined volume of particles into the pumping chamber to form a mixture of reagent fluid and particles, opening the valve, and forcing the mixture from the pumping chamber using the plunger to dispense the mixture from the outlet.Type: ApplicationFiled: November 21, 2017Publication date: March 15, 2018Applicant: Roche Diagnostics Operations, Inc.Inventors: Thorsten Brueckner, Nadine Losleben, Norbert Oranth
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Patent number: 9700845Abstract: A flow filtration system (1) for concentration of components contained in a fluid sample comprises a fluid channel (2) being formed by two conduits (4, 5) allowing a bidirectional flow of the fluid sample through the fluid channel (2), a tangential flow filtration module (3) and at least two pairs (8, 9) of piston pumps (6) each having two piston pumps (6), wherein the piston pumps (6) having a piston swept volume forming a reservoir being able to contain the fluid for volumes of up to 100 ml. The tangential flow filtration module (3) is located in the fluid channel (2) so that a fluid flowing through the channel (2) passes through the filtration module (3). At each end (10, 11) of the channel (2) one piston pump (6) of each pair (8, 9) of piston pumps (6) is located in such a manner that the piston pumps are fluidically connected in parallel.Type: GrantFiled: March 25, 2013Date of Patent: July 11, 2017Assignee: Hoffmann-La Roche Inc.Inventors: Norbert Oranth, Nadine Losleben, Sascha Lutz, Adelbert Grossmann
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Publication number: 20170184622Abstract: A method of operating a laboratory sample distribution system is presented. The method comprises a number of sample container carriers on a transport plane by a number of electro-magnetic actuators. The method is adapted to compensate deviations regarding physical properties of the sample container carriers, the transport plane and the electro-magnetic actuators compared to reference components. A laboratory automation system comprising such a laboratory sample distribution system is also presented.Type: ApplicationFiled: March 10, 2017Publication date: June 29, 2017Inventors: Achim Sinz, Christian Riether, Norbert Oranth, Martin Burri
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Patent number: 9573131Abstract: A cartridge for dispensing a fluid is presented. The cartridge comprises a reservoir chamber for receiving the fluid and for receiving a ventilation gas. The reservoir chamber comprises an inlet for receiving the ventilation gas and an outlet for dispensing the fluid. At least a portion of the reservoir chamber is filled with the ventilation gas when in an operating position. The inlet is located in the portion being filled with the ventilation gas. The fluid comprises a reagent. The cartridge further comprises a baffle for restricting gas diffusion through the inlet. The reservoir chamber receives the ventilation gas via the baffle. The inlet is maintains a constant gas pressure within the portion of the reservoir chamber that is being filled with the ventilation gas.Type: GrantFiled: November 3, 2014Date of Patent: February 21, 2017Assignee: Roche Diagnostics Operations, Inc.Inventors: Thorsten Brueckner, Peter Koltay, Norbert Oranth, Juergen Spinke, Laurent Tanguy
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Publication number: 20160231344Abstract: A cartridge for dispensing fluid is presented. The cartridge comprises a valve. The valve comprises a pumping chamber for pumping the fluid. The valve positions a pumping chamber conduit. The pumping chamber conduit is connected to the pumping chamber. The cartridge further comprises a plunger for changing the volume of the pumping chamber. The cartridge further comprises a reservoir conduit for connecting the reservoir with the valve. The valve positions the pumping chamber conduit to connect with the reservoir conduit. The cartridge further comprises an outlet conduit for dispensing the fluid. The valve further rotates the pumping chamber conduit to connect with the outlet conduit.Type: ApplicationFiled: April 19, 2016Publication date: August 11, 2016Inventors: Christoph Boehm, Peter Kupser, Norbert Oranth, Juergen Spinke, Thorsten Brueckner, Timo Klein
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Patent number: 9341641Abstract: A cartridge for dispensing fluid is presented. The cartridge comprises a valve. The valve comprises a pumping chamber for pumping the fluid. The valve positions a pumping chamber conduit. The pumping chamber conduit is connected to the pumping chamber. The cartridge further comprises a plunger for changing the volume of the pumping chamber. The cartridge further comprises a reservoir conduit for connecting the reservoir with the valve. The valve positions the pumping chamber conduit to connect with the reservoir conduit. The cartridge further comprises an outlet conduit for dispensing the fluid. The valve further rotates the pumping chamber conduit to connect with the outlet conduit.Type: GrantFiled: November 3, 2014Date of Patent: May 17, 2016Assignee: Roche Diagnostics Operations, Inc.Inventors: Christoph Boehm, Peter Kupser, Norbert Oranth, Juergen Spinke, Thorsten Brueckner, Timo Klein
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Publication number: 20150224500Abstract: A cartridge for dispensing a fluid is presented. The cartridge comprises a reservoir chamber for receiving the fluid and for receiving a ventilation gas. The reservoir chamber comprises an inlet for receiving the ventilation gas and an outlet for dispensing the fluid. At least a portion of the reservoir chamber is filled with the ventilation gas when in an operating position. The inlet is located in the portion being filled with the ventilation gas. The fluid comprises a reagent. The cartridge further comprises a baffle for restricting gas diffusion through the inlet. The reservoir chamber receives the ventilation gas via the baffle. The inlet is maintains a constant gas pressure within the portion of the reservoir chamber that is being filled with the ventilation gas.Type: ApplicationFiled: November 3, 2014Publication date: August 13, 2015Inventors: Thorsten Brueckner, Peter Koltay, Norbert Oranth, Juergen Spinke, Laurent Tanguy
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Publication number: 20150140669Abstract: A cartridge for dispensing fluid is presented. The cartridge comprises a valve. The valve comprises a pumping chamber for pumping the fluid. The valve positions a pumping chamber conduit. The pumping chamber conduit is connected to the pumping chamber. The cartridge further comprises a plunger for changing the volume of the pumping chamber. The cartridge further comprises a reservoir conduit for connecting the reservoir with the valve. The valve positions the pumping chamber conduit to connect with the reservoir conduit. The cartridge further comprises an outlet conduit for dispensing the fluid. The valve further rotates the pumping chamber conduit to connect with the outlet conduit.Type: ApplicationFiled: November 3, 2014Publication date: May 21, 2015Inventors: Christoph Boehm, Peter Kupser, Norbert Oranth, Juergen Spinke, Thursten Brueckner, Timo Klein
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Publication number: 20150083665Abstract: A flow filtration system (1) for concentration of components contained in a fluid sample comprises a fluid channel (2) being formed by two conduits (4, 5) allowing a bidirectional flow of the fluid sample through the fluid channel (2), a tangential flow filtration module (3) and at least two pairs (8, 9) of piston pumps (6) each having two piston pumps (6), wherein the piston pumps (6) having a piston swept volume forming a reservoir being able to contain the fluid for volumes of up to 100 ml. The tangential flow filtration module (3) is located in the fluid channel (2) so that a fluid flowing through the channel (2) passes through the filtration module (3). At each end (10, 11) of the channel (2) one piston pump (6) of each pair (8, 9) of piston pumps (6) is located in such a manner that the piston pumps are fluidically connected in parallel.Type: ApplicationFiled: March 25, 2013Publication date: March 26, 2015Inventors: Norbert Oranth, Nadine Losleben, Sascha Lutz, Adelbert Grossmann
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Publication number: 20150041375Abstract: A micro fluid filtration system (100) preferably for increasing the concentration of components contained in a fluid sample has a fluid circuitry (1). The fluid circuitry (1) comprises the following elements: A tangential flow filtration element (7) capable for separating the fluid sample into a retentate stream and a permeate stream upon passage of the fluid, an element for pumping (3) for creating and driving a fluid flow through the fluid circuitry (1) and at least one element for obtaining information about the properties of the fluid sample within the circuitry. The circuitry further comprises a plurality of conduits (24) connecting the elements of the fluid circuitry (1) through which a fluid stream of the fluid sample is conducted. The circuitry (1) has a minimal working volume of at most 5 ml, which is the minimal fluid volume retained in the elements and the conduits (24) of the circuitry (1) such that the fluid can be recirculated in the circuitry (1) without pumping air through the circuitry (1).Type: ApplicationFiled: March 25, 2013Publication date: February 12, 2015Applicant: Hoffmann-La Roche Inc.Inventors: Norbert Oranth, Nadine Losleben, Sascha Lutz, Adelbert Grossmann
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Publication number: 20150041395Abstract: A micro flow filtration system comprises a fluid circuitry (3) and a first reservoir (1) outside the circuitry (3) suitable for containing a fluid. The fluid circuitry (3) comprises a tangential flow filtration module (10) capable of separating the fluid sample into a retentate stream and a permeate stream upon passage of the fluid sample into the tangential flow filtration module (10) through an inlet feed (18). The fluid circuitry (3) further comprises a second reservoir (2) integrated in the fluid circuitry (3), a pump (5) for creating and driving a fluid flow, optionally at least one pressure sensor (6, 7 or 8) for acquiring and detecting data about the fluid sample, optionally a pressure regulator (9) for regulating the flow in the fluid circuitry (3) and a plurality of conduits (22) forming the fluid circuitry (3) together with the second reservoir (2), the TFF-module (10), the pump (5), the pressure sensor (6, 7 or 8) (if present) and the pressure regulator (9) (if present).Type: ApplicationFiled: March 25, 2013Publication date: February 12, 2015Applicant: Hoffmann-La Roche Inc.Inventors: Norbert Oranth, Nadine Losleben, Sascha Lutz, Adelbert Grossmann