Abstract: A microfluidic cartridge having a detection chamber for detecting biomolecules in a sample solution. A CMOS-based microchip having a sensor area is arranged in the detection chamber and a contact area that is fluid-tightly separated from the detection chamber. The sensor area of the microchip including an array of functionalized test sites for electrochemically detecting biomolecules in the sample solution, and each test site in the sensor area is furnished with its own sigma-delta modulator for the analog-to-digital conversion of electrical signals produced at the test sites upon electrochemical detection.

Abstract: The present invention relates to a microfluidic cartridge (100) for detecting biomolecules in a sample solution, having a detection chamber (140) to which the sample solution is suppliable through a feed channel (124) and from which the analyzed sample solution is drainable through an outlet channel (126), a CMOS-based microchip (142) that comprises a sensor area (144) arranged in the detection chamber (140) and a contact area (146) that is fluid-tightly separated from the detection chamber (140), the sensor area (144) of the microchip (142) including an array of functionalized test sites (130) for electrochemically detecting biomolecules in the sample solution, and each test site (130) in the sensor area (140) being furnished with its own sigma-delta modulator (132) for the analog-to-digital conversion of electrical signals produced at the test sites (130) upon electrochemical detection.

Abstract: A device is described to perform reactions, in which the device includes at least one test cell with a cavity to receive the test sample and at least a first, a second and a third spatially discrete regulatable temperature units. The three temperature units thus define three spatially discrete temperature areas. At least one means is provided to perform a rotary movement of the test cell. The cavity provided to receive the test sample can be moved across the three spatially discrete temperature areas, in which the cavity in one position of the test cell, remains in contact with a least two of the temperature areas.

Abstract: An electrical substrate for use as a carrier of biomolecules in a method for electrochemical detection in an electrolyte solution exhibits an insulating support plate (12) bearing a conductive pattern (20; 20A-20C, 28) having conductor paths (20; 20A-20C) and connecting contact surfaces, and, disposed on the conductor paths (20; 20A-20C), test sites (24) for the application of biomolecules (26), the conductor paths (20; 20A-20C) exhibiting a metal core (14) made of a highly conductive base metal and an external gold layer (18), and the conductor paths (20; 20A-20C) being provided with a diffusion barrier layer (16) that prevents direct contact of the electrolyte solution with the metal core (14) during the electrochemical detection method.