Patents by Inventor Norbert Waldöfner
Norbert Waldöfner has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 9962442Abstract: The present invention relates to a method for producing a suspension of agglomerates of magnetic alkoxysilane-coated metal nanoparticles, wherein an aqueous suspension of magnetic metal nanoparticles is incubated with alkoxysilane, wherein the incubation is carried out essentially in the absence of an organic solvent. The present invention further relates to suspension of agglomerates of magnetic alkoxysilane-coated metal containing nanoparticles obtainable by the method of the present invention and to a composition comprising agglomerates of magnetic alkoxysilane-coated metal nanoparticles, wherein the agglomerates have an average size of 30 to 450 nm, preferably of 50 to 350 nm and especially of 70 to 300 nm as determined by light scattering.Type: GrantFiled: June 30, 2016Date of Patent: May 8, 2018Assignee: MAGFORCE AGInventors: Norbert Waldoefner, Andreas Jordan
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Patent number: 9827312Abstract: The present invention relates to compositions containing nanoparticies and uses of said composition for transferring therapeutically active substances into cells by means of specifically coated nanoparticles. The chemical design of the particles is such that a large amount thereof is absorbed into the cells. No direct bond between nanoparticle and the therapeutically active substance is required for the transfer into the cells. Thanks to said transfer, an increased efficacy of the substance and simultaneously reduced systemic toxicity is achieved, i.e. an increase in the efficacy while the side effects are reduced.Type: GrantFiled: September 9, 2015Date of Patent: November 28, 2017Assignee: MAGFORCE AGInventors: Andreas Jordan, Norbert Waldoefner, Regina Scholz
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Patent number: 9814677Abstract: Embodiments herein relate to the production of biocompatible magnetic nanoparticles with a high SAR-value which produce a large amount of heat when exposed to an alternating magnetic field. The produced heat can be used among others for therapeutic purposes, in particular for combating cancer.Type: GrantFiled: May 15, 2014Date of Patent: November 14, 2017Assignee: MAGFORCE AGInventors: Norbert Waldoefner, Kerstin Stief
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Publication number: 20160367673Abstract: The present invention relates to a method for producing a suspension of agglomerates of magnetic alkoxysilane-coated metal nanoparticles, wherein an aqueous suspension of magnetic metal nanoparticles is incubated with alkoxysilane, wherein the incubation is carried out essentially in the absence of an organic solvent. The present invention further relates to suspension of agglomerates of magnetic alkoxysilane-coated metal containing nanoparticles obtainable by the method of the present invention and to a composition comprising agglomerates of magnetic alkoxysilane-coated metal nanoparticles, wherein the agglomerates have an average size of 30 to 450 nm, preferably of 50 to 350 nm and especially of 70 to 300 nm as determined by light scattering.Type: ApplicationFiled: June 30, 2016Publication date: December 22, 2016Inventors: Norbert WALDOEFNER, Andreas JORDAN
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Patent number: 9408912Abstract: The present invention relates to a method for producing a suspension of agglomerates of magnetic alkoxysilane-coated metal nanoparticles, wherein an aqueous suspension of magnetic metal nanoparticles is incubated with alkoxysilane, wherein the incubation is carried out essentially in the absence of an organic solvent. The present invention further relates to suspension of agglomerates of magnetic alkoxysilane-coated metal containing nanoparticles obtainable by the method of the present invention and to a composition comprising agglomerates of magnetic alkoxysilane-coated metal nanoparticles, wherein the agglomerates have an average size of 30 to 450 nm, preferably of 50 to 350 nm and especially of 70 to 300 nm as determined by light scattering.Type: GrantFiled: August 7, 2012Date of Patent: August 9, 2016Assignee: MagForce AGInventors: Norbert Waldöfner, Andreas Jordan
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Patent number: 9345768Abstract: The present invention relates to nanoparticles, wherein at least one therapeutically active substance is bound to said nanoparticle and wherein the separation of the at least one therapeutically active substance from the nanoparticle is caused or initiated by an alternating magnetic filed. Furthermore, the present invention relates to pharmaceutical compositions, in particular to injection solutions containing the nanoparticles as well as to the use thereof for the treatment of cancer.Type: GrantFiled: April 12, 2006Date of Patent: May 24, 2016Assignee: MAGFORCE AGInventors: Andreas Jordan, Norbert Waldoefner, Klaus Decken, Regina Scholz
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Publication number: 20160067338Abstract: The present invention relates to compositions containing nanoparticies and uses of said composition for transferring therapeutically active substances into cells by means of specifically coated nanoparticles. The chemical design of the particles is such that a large amount thereof is absorbed into the cells. No direct bond between nanoparticle and the therapeutically active substance is required for the transfer into the cells. Thanks to said transfer, an increased efficacy of the substance and simultaneously reduced systemic toxicity is achieved, i.e. an increase in the efficacy while the side effects are reduced.Type: ApplicationFiled: September 9, 2015Publication date: March 10, 2016Inventors: Andreas JORDAN, Norbert WALDOEFNER, Regina SCHOLZ
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Publication number: 20140302154Abstract: Embodiments herein relate to the production of biocompatible magnetic nanoparticles with a high SAR-value which produce a large amount of heat when exposed to an alternating magnetic field. The produced heat can be used among others for therapeutic purposes, in particular for combating cancer.Type: ApplicationFiled: May 15, 2014Publication date: October 9, 2014Applicant: MagForce AGInventors: Norbert WALDOEFNER, Kerstin STIEF
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Patent number: 8771699Abstract: Embodiments herein relate to the production of biocompatible magnetic nanoparticles with a high SAR-value which produce a large amount of heat when exposed to an alternating magnetic field. The produced heat can be used among others for therapeutic purposes, in particular for combating cancer.Type: GrantFiled: January 9, 2009Date of Patent: July 8, 2014Assignee: Magforce AGInventors: Norbert Waldoefner, Kerstin Stief
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Publication number: 20140154324Abstract: The present invention relates to a method for producing a suspension of agglomerates of magnetic alkoxysilane-coated metal nanoparticles, wherein an aqueous suspension of magnetic metal nanoparticles is incubated with alkoxysilane, wherein the incubation is carried out essentially in the absence of an organic solvent. The present invention further relates to suspension of agglomerates of magnetic alkoxysilane-coated metal containing nanoparticles obtainable by the method of the present invention and to a composition comprising agglomerates of magnetic alkoxysilane-coated metal nanoparticles, wherein the agglomerates have an average size of 30 to 450 nm, preferably of 50 to 350 nm and especially of 70 to 300 nm as determined by light scattering.Type: ApplicationFiled: August 7, 2012Publication date: June 5, 2014Inventors: Norbert Waldöfner, Andreas Jordan
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Publication number: 20120225128Abstract: The present invention relates to compositions containing nanoparticies and uses of said composition for transferring therapeutically active substances into cells by means of specifically coated nanoparticles. The chemical design of the particles is such that a large amount thereof is absorbed into the cells. No direct bond between nanoparticle and the therapeutically active substance is required for the transfer into the cells. Thanks to said transfer, an increased efficacy of the substance and simultaneously reduced systemic toxicity is achieved, i.e. an increase in the efficacy while the side effects are reduced.Type: ApplicationFiled: May 11, 2012Publication date: September 6, 2012Inventors: Andreas JORDAN, Norbert Waldoefner, Regina Scholz
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Publication number: 20110052609Abstract: Embodiments herein relate to the production of biocompatible magnetic nanoparticles with a high SAR-value which produce a large amount of heat when exposed to an alternating magnetic field. The produced heat can be used among others for therapeutic purposes, in particular for combating cancer.Type: ApplicationFiled: January 9, 2009Publication date: March 3, 2011Inventors: Norbert Waldoefner, Kerstin Stief
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Publication number: 20080268061Abstract: The present invention relates to nanoparticles, wherein at least one therapeutically active substance is bound to said nanoparticle and wherein the separation of the at least one therapeutically active substance from the nanoparticle is caused or initiated by an alternating magnetic filed. Furthermore, the present invention relates to pharmaceutical compositions, in particular to injection solutions containing the nanoparticles as well as to the use thereof for the treatment of cancer.Type: ApplicationFiled: April 12, 2006Publication date: October 30, 2008Inventors: Andreas Jordan, Norbert Waldoefner, Klaus Decken, Regina Scholz
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Publication number: 20080187595Abstract: The present invention relates to compositions containing nanoparticles and uses of said composition for transferring therapeutically active substances into cells by means of specifically coated nanoparticles. The chemical design of the particles is such that a large amount thereof is absorbed into the cells. No direct bond between nanoparticle and the therapeutically active substance is required for the transfer into the cells. Thanks to said transfer, an increased efficacy of the substance and simultaneously reduced systemic toxicity is achieved, i.e. an increase in the efficacy while the side effects are reduced.Type: ApplicationFiled: August 21, 2006Publication date: August 7, 2008Inventors: Andreas Jordan, Norbert Waldoefner, Regina Scholz