Patents by Inventor Norberto Andres COLLAZO MUÑOZ

Norberto Andres COLLAZO MUÑOZ has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Promoter with an enriched Cytosine-Guanine dinucleotide region, vectors, cellular lines, method for producing recombinant protein
    Patent number: 11618904
    Abstract: The present invention relates to the field of genetic engineering, preferably the expression of recombinant proteins (RP). In particular, the invention relates to a promoter and variants thereof having an equal function and more than 90% sequence identity. The promoter comprises a fragment of 1147 base pairs (bp) of a first promoter, promoter of the ?-actin gene of the Cricetulus griseus genome, enriched in cytosine-guanine dinucleotides (RegCG). The first promoter can be upstream of a second promoter, cytomegalovirus (CMV) promoter. The invention also relates to vectors, transfected cellular lines and a method for producing RP in mammal cells that have been transfected with vectors containing said promoter or variants thereof.
    Type: Grant
    Filed: June 9, 2017
    Date of Patent: April 4, 2023
    Assignees: UNIVERSIDAD DE CHILE, BPH S.A., INGENERIA ORBICORP LTDA
    Inventors: Juan Carlos Aguillon Gutierrez, Maria Carmen Molina Sampayo, Roberto Aquiles Zuñiga Olate, Matias Fernando Guitierrez Gonzalez, Norberto Andres Collazo Muñoz, Jaime Camilo Teneb Lobos
  • PROMOTER WITH AN ENRICHED CYTOSINE-GUANINE DINUCLEOTIDE REGION, VECTORS, CELLULAR LINES, METHOD FOR PRODUCING RECOMBINANT PROTEIN
    Publication number: 20190309323
    Abstract: The present invention relates to the field of genetic engineering, preferably the expression of recombinant proteins (RP). In particular, the invention relates to a promoter and variants thereof having an equal function and more than 90% sequence identity. The promoter comprises a fragment of 1147 base pairs (bp) of a first promoter, promoter of the ?-actin gene of the Cricetulus griseus genome, enriched in cytosine-guanine dinucleotides (RegCG). The first promoter can be upstream of a second promoter, cytomegalovirus (CMV) promoter. The invention also relates to vectors, transfected cellular lines and a method for producing RP in mammal cells that have been transfected with vectors containing said promoter or variants thereof.
    Type: Application
    Filed: June 9, 2017
    Publication date: October 10, 2019
    Inventors: Juan Carlos AGUILLON GUTIERREZ, Maria Carmen MOLINA SAMPAYO, Roberto Aquiles ZUÑIGA OLATE, Matias Fernando GUITIERREZ GONZALEZ, Norberto Andres COLLAZO MUÑOZ, Jaime Camilo TENEB LOBOS