Abstract: Biomarkers for diagnosing the disease activity, disease severity or disease type of severe cutaneous adverse drug reactions (SCARs) such as drug-induced hypersensitivity syndrome and Stevens-Johnson syndrome/toxic epidermal necrolysis are provided. Also provided is a method of testing SCARs, comprising measuring the expression of at least one protein selected from the group consisting of stratifin, TNF receptor superfamily member 8 (CD30/TNFRSF8), interleukin-1 receptor antagonist (IL-1Ra), and TNF receptor superfamily member 6B (DcR3/TNFRSF6B) in a sample derived from a subject.

Abstract: An object of the present invention is to provide a method for detecting malignant ovarian tumor as distinguished from benign ovarian tumor, and a reagent that can be used for the method. Provided are a method for detecting malignant ovarian tumor (excluding high-grade serous carcinoma) as distinguished from benign ovarian tumor, characterized by measuring the amount of TFPI2 in a sample from a patient, and a reagent for detecting malignant ovarian tumor (excluding high-grade serous carcinoma) as distinguished from benign ovarian tumor contains an antibody that specifically recognizes TFPI2 processing polypeptide and intact TFPI2.

Abstract: The present invention aims to provide a method for simply and highly accurately detecting castration-resistant prostate cancer (CRPC), and a reagent that can be used for this method. By measuring the level of GDF15 propeptide present in a sample as a novel detection marker for CRPC, acquisition of castration resistance in a prostate cancer patient during or after endocrine therapy is detected. An antibody that specifically recognizes GDF15 propeptide is included in the CRPC detection reagent.

Abstract: The present invention aims to provide a method for detecting, with high sensitivity and specificity, ovarian clear cell adenocarcinoma, which is highly malignant, among benign and malignant ovarian tumors having various tissue types, and a reagent that can be used for the method. The present invention provides NT-TFPI2, which is a novel processed tissue factor pathway inhibitor 2 polypeptide, as a new detection marker for ovarian clear cell adenocarcinoma. The detection of ovarian clear cell adenocarcinoma is carried out by measuring the amount of NT-TFPI2, or the total amount of NT-TFPI2 and intact TFPI2. The reagent for detecting ovarian clear cell adenocarcinoma contains an antibody that specifically recognizes NT-TFPI2 and intact TFPI2.

Abstract: The present invention aims to provide a method for simply and highly accurately detecting castration-resistant prostate cancer (CRPC), and a reagent that can be used for this method. By measuring the level of GDF15 propeptide present in a sample as a novel detection marker for CRPC, acquisition of castration resistance in a prostate cancer patient during or after endocrine therapy is detected. An antibody that specifically recognizes GDF15 propeptide is included in the CRPC detection reagent.

Abstract: An object of the present invention is to provide a method for detecting renal cancer, and a reagent that can be used for the method. Provided is a method for detecting renal cancer, which includes measuring the amount of TFPI2 in a sample derived from a patient. An antibody that specifically recognizes NT-TFPI2 and intact TFPI2 is included in a detection reagent for renal cancer.

Abstract: The present invention aims to provide a method for detecting, with high sensitivity and specificity, ovarian clear cell adenocarcinoma, which is highly malignant, among benign and malignant ovarian tumors having various tissue types, and a reagent that can be used for the method. The present invention provides NT-TFPI2, which is a novel processed tissue factor pathway inhibitor 2 polypeptide, as a new detection marker for ovarian clear cell adenocarcinoma. The detection of ovarian clear cell adenocarcinoma is carried out by measuring the amount of NT-TFPI2, or the total amount of NT-TFPI2 and intact TFPI2. The reagent for detecting ovarian clear cell adenocarcinoma contains an antibody that specifically recognizes NT-TFPI2 and intact TFPI2.

Abstract: Novel means capable of detecting an arteriosclerotic lesion in a body by a less invasive, simple method is disclosed. The method for detecting arteriosclerosis according to the present invention comprises measuring the myosin heavy chain 11 level in a blood sample isolated from a subject. A myosin heavy chain 11 level higher than that of a healthy individual is indicative of the presence of arteriosclerosis in the subject. Since the present invention enables detection of arteriosclerosis by a blood test, a less invasive, simple test can be carried out. Unlike methods for testing only particular regions such as carotid artery ultrasonography, the present invention is expected to reflect the conditions of blood vessels in the whole body.

Abstract: The present invention aims to provide a method for detecting, with high sensitivity and specificity, ovarian clear cell adenocarcinoma, which is highly malignant, among benign and malignant ovarian tumors having various tissue types, and a reagent that can be used for the method. The present invention provides NT-TFPI2, which is a novel processed tissue factor pathway inhibitor 2 polypeptide, as a new detection marker for ovarian clear cell adenocarcinoma. The detection of ovarian clear cell adenocarcinoma is carried out by measuring the amount of NT-TFPI2, or the total amount of NT-TFPI2 and intact TFPI2. The reagent for detecting ovarian clear cell adenocarcinoma contains an antibody that specifically recognizes NT-TFPI2 and intact TFPI2.

Abstract: A refrigerator, having a motor for driving a compressor, an inverter for controlling the operation of the motor, a converter responsive to AC to perform a boosting function to supply DC of variable voltage to the inverter, converter control means for controlling the converter so that a plurality of DC voltages are outputted thereby and inverter control means for controlling the inverter in pulse width modulation each of the plurality of voltages. The lowest voltage among the plurality of voltages being a voltage which turns off the boosting function of the converter.

Abstract: A refrigerator, having a motor for driving a compressor, an inverter for controlling the operation of the motor, a converter responsive to AC to perform a boosting function to supply DC of variable voltage to the inverter, converter control means for controlling the converter so that a plurality of DC voltages are outputted thereby and inverter control means for controlling the inverter in pulse width modulation each of the plurality of voltages. The lowest voltage among the plurality of voltages being a voltage which turns off the boosting function of the converter.

Abstract: When inverter control is implemented in a refrigerator or the like, the rotating speed of a compressor motor is often operated at the preset minimum rotating speed. At this time, there has been a problem that when the DC voltage is boosted, the efficiency of the circuit drops due to switching loss in the power element. Still more, when the DC voltage is boosted even at the minimum rotating speed, the lowest voltage of the DC voltage must be controlled at 163 V or more including the fluctuation of the voltage. Therefore, there has been a problem in that the efficiency of the compressor motor also drops.

Abstract: A high-efficiency, compact and low-cost electric power storage air-conditioning system incorporates inside its air-conditioner an electric power storage unit including a battery which is electrically interconnected to a d.c. system of the air-conditioner. Charging of the battery is controlled to be executed only during a steady operation of the air-conditioner when its load is light. Since a d.c. voltage of the battery is used directly as a d.c. voltage to drive the air-conditioner, a high efficiency, minimized loss and economical operation conditioning system is achieved.

Abstract: A brushless motor accommodated within a case and having mounted on a substrate rotor speed detection sensors and a monolithic integrated circuit which includes an inverter for driving the rotor, drive circuits for driving the inverter, power source circuit for supplying a power required by each circuit, circuits for controlling the speed of the rotor and a protection circuit for protecting the inverter from excess current.

Abstract: A drive control apparatus for controlling a motor to drive the compressor of an air conditioner, according to the present invention, includes a rectifying circuit for converting an AC voltage into a DC voltage, an inverter having a combination of a plurality of power controlling semiconductor devices and which controls the DC voltage from the rectifying circuit in accordance with a drive signal supplied to the combination of the semiconductor devices so as to generate an AC drive current to the drive, and a drive circuit for generating the drive signal to the inverter. The drive circuit formed as a monolithic integrated circuit having a dielectric separation structure, with the monolithic integrated circuit and the inverter being mounted on a common module substrate.