Patents by Inventor Norihiko Watanabe

Norihiko Watanabe has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Compositions and methods for modulating lymphocyte activity
    Patent number: 9045562
    Abstract: The present invention provides a novel lymphocyte inhibitory receptor termed BTLA which is expressed on both T and B cells, and identifies HVEM as interacting with BTLA. Methods and compositions for modulating BTLA-mediated signaling and interfering with the interaction of BTLA and HVEM for therapeutic, diagnostic and research purposes are also provided.
    Type: Grant
    Filed: December 30, 2011
    Date of Patent: June 2, 2015
    Assignee: Washington University
    Inventors: Kenneth M. Murphy, Theresa L. Murphy, John R. Sedy, Michelle A. Hurchla Pyles, Norihiko Watanabe, Jianfei Yang
  • Method of identifying a compound for preventing and/or treating an autoimmune disease
    Patent number: 8581022
    Abstract: A method of identifying a compound for preventing and/or treating an autoimmune disease is described which comprises obtaining a (BTLA?/?) NKT cell from a non-human animal, contacting the (BTLA?/?) NKT cell ex vivo with a test compound, in the presence of an antigen, measuring a response of the (BTLA?/?) NKT cell to the antigen, comparing the response of the (BTLA?/?) NKT cell to the antigen with a response of a (BTLA?/?) NKT cell in control assay, and selecting the compound that reduces the response of the (BTLA?/?) NKT cell in the presence of an antigen compared to a response of a (BTLA?/?) NKT cell in the control assay. Other methods of identifying a compound for preventing and/or treating an autoimmune disease are also described.
    Type: Grant
    Filed: March 30, 2010
    Date of Patent: November 12, 2013
    Assignee: National University Corporation Chiba University
    Inventors: Norihiko Watanabe, Yoshihiro Oya
  • Compositions and methods for modulating lymphocyte activity
    Patent number: 8546541
    Abstract: The present invention provides a novel lymphocyte inhibitory receptor termed BTLA which is expressed on both T and B cells, and identifies HVEM as interacting with BTLA. Methods and compositions for modulating BTLA-mediated signaling and interfering with the interaction of BTLA and HVEM for therapeutic, diagnostic and research purposes are also provided.
    Type: Grant
    Filed: December 23, 2010
    Date of Patent: October 1, 2013
    Assignee: Washington University
    Inventors: Kenneth M. Murphy, Theresa L. Murphy, John R. Sedy, Michelle A. Hurchla Pyles, Norihiko Watanabe, Jianfei Yang
  • COMPOSITIONS AND METHODS FOR MODULATING LYMPHOCYTE ACTIVITY
    Publication number: 20120322986
    Abstract: The present invention provides a novel lymphocyte inhibitory receptor termed BTLA which is expressed on both T and B cells, and identifies HVEM as interacting with BTLA. Methods and compositions for modulating BTLA-mediated signaling and interfering with the interaction of BTLA and HVEM for therapeutic, diagnostic and research purposes are also provided.
    Type: Application
    Filed: May 17, 2012
    Publication date: December 20, 2012
    Applicant: THE WASHINGTON UNIVERSITY
    Inventors: Kenneth M. Murphy, Theresa L. Murphy, John R. Sedy, Michelle A. Hurchla Pyles, Norihiko Watanabe, Jianfei Yang
  • COMPOSITIONS AND METHODS FOR MODULATING LYMPHOCYTE ACTIVITY
    Publication number: 20120232259
    Abstract: The present invention provides a novel lymphocyte inhibitory receptor termed BTLA which is expressed on both T and B cells, and identifies B7 family member B7x as interacting with BTLA to attenuate lymphocyte activity. Methods and compositions for modulating BTLA-mediated negative signaling and interfering with the interaction of BTLA and B7x for therapeutic, diagnostic and research purposes are also provided.
    Type: Application
    Filed: April 3, 2012
    Publication date: September 13, 2012
    Applicant: THE WASHINGTON UNIVERSITY
    Inventors: Kenneth Murphy, Norihiko Watanabe, Theresa Murphy, Jianfei Yang
  • COMPOSITIONS AND METHODS FOR MODULATING LYMPHOCYTE ACTIVITY
    Publication number: 20120214972
    Abstract: The present invention provides a novel lymphocyte inhibitory receptor termed BTLA which is expressed on both T and B cells, and identifies B7 family member B7x as interacting with BTLA to attenuate lymphocyte activity. Methods and compositions for modulating BTLA-mediated negative signaling and interfering with the interaction of BTLA and B7x for therapeutic, diagnostic and research purposes are also provided.
    Type: Application
    Filed: October 20, 2010
    Publication date: August 23, 2012
    Applicant: THE WASHINGTON UNIVERSITY
    Inventors: Kenneth Murphy, Norihiko Watanabe, Theresa Murphy, Jianfei Yang
  • COMPOSITIONS AND METHODS FOR MODULATING LYMPHOCYTE ACTIVITY
    Publication number: 20120207759
    Abstract: The present invention provides a novel lymphocyte inhibitory receptor termed BTLA which is expressed on both T and B cells, and identifies HVEM as interacting with BTLA. Methods and compositions for modulating BTLA-mediated signaling and interfering with the interaction of BTLA and HVEM for therapeutic, diagnostic and research purposes are also provided.
    Type: Application
    Filed: December 30, 2011
    Publication date: August 16, 2012
    Applicant: THE WASHINGTON UNIVERSITY
    Inventors: Kenneth M. Murphy, Theresa L. Murphy, John R. Sedy, Michelle A. Hurchla Pyles, Norihiko Watanabe, Jianfei Yang
  • USES OF MAMMALIAN CYTOKINE; RELATED REAGENTS
    Publication number: 20110229434
    Abstract: Provided are methods of modulating dendritic cell activity using agonists or antagonists of a mammalian cytokine. Also provided are methods of treating immune disorders.
    Type: Application
    Filed: March 21, 2011
    Publication date: September 22, 2011
    Inventors: RENE DE WAAL MALEFYT, Liu Yong-Jun, Marehalli L. Nagalakshmi, Vassili Soumelis, Norihiko Watanabe, Wei Yuan
  • COMPOSITIONS AND METHODS FOR MODULATING LYMPHOCYTE ACTIVITY
    Publication number: 20110230647
    Abstract: The present invention provides a novel lymphocyte inhibitory receptor termed BTLA which is expressed on both T and B cells, and identifies HVEM as interacting with BTLA. Methods and compositions for modulating BTLA-mediated signaling and interfering with the interaction of BTLA and HVEM for therapeutic, diagnostic and research purposes are also provided.
    Type: Application
    Filed: December 23, 2010
    Publication date: September 22, 2011
    Applicant: THE WASHINGTON UNIVERSITY
    Inventors: Kenneth M. Murphy, Theresa L. Murphy, John R. Sedy, Michelle A. Hurchla Pyles, Norihiko Watanabe, Jianfei Yang
  • Method Of Identifying A Compound For Preventing And/Or Treating An Autoimmune Disease
    Publication number: 20110004953
    Abstract: A method of identifying a compound for preventing and/or treating an autoimmune disease is described which comprises obtaining a (BTLA?/?) NKT cell from a non-human animal, contacting the (BTLA?/?) NKT cell ex vivo with a test compound, in the presence of an antigen, measuring a response of the (BTLA?/?) NKT cell to the antigen, comparing the response of the (BTLA?/?) NKT cell to the antigen with a response of a (BTLA?/?) NKT cell in control assay, and selecting the compound that reduces the response of the (BTLA?/?) NKT cell in the presence of an antigen compared to a response of a (BTLA?/?) NKT cell in the control assay. Other methods of identifying a compound for preventing and/or treating an autoimmune disease are also described.
    Type: Application
    Filed: March 30, 2010
    Publication date: January 6, 2011
    Applicant: NATIONAL UNIVERSITY CORPORATION CHIBA UNIVERSITY
    Inventors: Norihiko Watanabe, Yoshihiro Oya
  • USES OF MAMMALIAN CYTOKINE; RELATED REAGENTS
    Publication number: 20100136003
    Abstract: Provided are methods of modulating dendritic cell activity using agonists or antagonists of a mammalian cytokine. Also provided are methods of treating immune disorders.
    Type: Application
    Filed: November 10, 2009
    Publication date: June 3, 2010
    Inventors: RENE DE WAAL MALEFYT, Liu Yong-Jun, Marehalli L. Nagalakshmi, Vassili Soumelis, Norihiko Watanabe, Wei Yuan
  • USES OF MAMMALIAN CYTOKINE: RELATED REAGENTS
    Publication number: 20090017018
    Abstract: Provided are methods of modulating dendritic cell activity using agonists or antagonists of a mammalian cytokine. Also provided are methods of treating immune disorders.
    Type: Application
    Filed: September 24, 2007
    Publication date: January 15, 2009
    Inventors: Rene DE WAAL MALEFYT, Yong-Jun Liu, Marehalli L. Nagalakshmi, Vassili Soumelis, Norihiko Watanabe, Wei Yuan
  • COMPOSITIONS AND METHODS FOR MODULATING LYMPHOCTE ACTIVITY
    Publication number: 20080269464
    Abstract: The present invention provides a novel lymphocyte inhibitory receptor termed BTLA which is expressed on both T and B cells, and identifies B7 family member B7x as interacting with BTLA to attenuate lymphocyte activity. Methods and compositions for modulating BTLA-mediated negative signaling and interfering with the interaction of BTLA and B7x for therapeutic, diagnostic and research purposes are also provided.
    Type: Application
    Filed: October 19, 2007
    Publication date: October 30, 2008
    Applicant: WASHINGTON UNIVERSITY IN ST. LOUIS
    Inventors: Kenneth M. Murphy, Norihiko Watanabe, Theresa Murphy, Jianfei Yang, Xingxing Zang
  • BTLA nucleic acids
    Patent number: 7304149
    Abstract: The present invention provides a novel lymphocyte inhibitory receptor termed BTLA which is expressed on both T and B cells, and identifies B7 family member B7x as interacting with BTLA to attenuate lymphocyte activity. Methods and compositions for modulating BTLA-mediated negative signaling and interfering with the interaction of BTLA and B7x for therapeutic, diagnostic and research purposes are also provided.
    Type: Grant
    Filed: June 20, 2003
    Date of Patent: December 4, 2007
    Assignee: Washington University in St. Louis
    Inventors: Kenneth P. Murphy, Norihiko Watanabe, Theresa L. Murphy, Jianfei Yang
  • Uses of mammalian cytokine: related reagents
    Publication number: 20070020262
    Abstract: Provided are methods of modulating dendritic cell activity using agonists or antagonists of a mammalian cytokine. Also provided are methods of treating immune disorders.
    Type: Application
    Filed: September 22, 2006
    Publication date: January 25, 2007
    Inventors: Rene De Waal Malefyt, Liu Yong-Jun, Marehalli Nagalakshmi, Vassili Soumelis, Norihiko Watanabe, Wei Yuan
  • Engine valve train
    Patent number: 6830018
    Abstract: An engine valve train having a camshaft supported on a camshaft holder and driving inlet valves to open and close via inlet rocker arms; an electromagnetic actuator mechanism including an armature; a holding rod connected to the armature and pressing against a stem end of the inlet valve so as to hold the inlet valve in an open state; and, a hydraulic damper mechanism absorbing an impact which is generated by the inlet valve when the inlet valve is released from being held by the electromagnetic actuator mechanism so as to be restored to a closed state and is then seated, wherein the hydraulic damper mechanism is supported on the camshaft holder.
    Type: Grant
    Filed: July 14, 2003
    Date of Patent: December 14, 2004
    Assignee: Honda Giken Kogyo Kabushiki Kaisha
    Inventors: Mitsuru Sugimoto, Atsushi Umemoto, Norihiko Watanabe
  • Compositions and methods for modulating lymphocyte activity
    Publication number: 20040175380
    Abstract: The present invention provides a novel lymphocyte inhibitory receptor termed BTLA which is expressed on both T and B cells, and identifies B7 family member B7x as interacting with BTLA to attenuate lymphocyte activity. Methods and compositions for modulating BTLA-mediated negative signaling and interfering with the interaction of BTLA and B7x for therapeutic, diagnostic and research purposes are also provided.
    Type: Application
    Filed: June 20, 2003
    Publication date: September 9, 2004
    Inventors: James P. Allison, Kenneth P. Murphy, Norihiko Watanabe, Theresa L. Murphy, Jianfei Yang, Xingxing Zang
  • Engine valve train
    Publication number: 20040011310
    Abstract: An engine valve train has: a camshaft supported on a camshaft holder and driving inlet valves to open and close via inlet rocker arms; an electromagnetic actuator mechanism including an armature; a holding rod connected to the armature and pressing against a stem end of the inlet valve so as to hold the inlet valve in an open state; and, a hydraulic damper mechanism absorbing an impact which is generated by the inlet valve when the inlet valve is released from being held by the electromagnetic actuator mechanism so as to be restored to a closed state and is then seated, wherein the hydraulic damper mechanism is supported on the camshaft holder.
    Type: Application
    Filed: July 14, 2003
    Publication date: January 22, 2004
    Applicant: HONDA GIKEN KOGYO KABUSHIKI KAISHA
    Inventors: Mitsuru Sugimoto, Atsushi Umemoto, Norihiko Watanabe
  • Uses of mammalian cytokine; related reagents
    Publication number: 20030186875
    Abstract: Provided are methods of modulating dendritic cell activity using agonists or antagonists of a mammalian cytokine. Also provided are methods of treating immune disorders.
    Type: Application
    Filed: January 30, 2003
    Publication date: October 2, 2003
    Inventors: Rene De Waal Malefyt, Liu Yong-Jun, Marehalli L. Nagalakshmi, Vassili Soumelis, Norihiko Watanabe, Wei Yuan