Patents by Inventor Norihiro Kokudo
Norihiro Kokudo has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11890145Abstract: An adhesion-preventing material having a high adhesion-preventing effect has been demanded. An adhesion-preventing material including a sterilized biocompatible sponge-like laminate, wherein the sponge-like laminate comprises a sponge-like first layer and a sponge-like second layer each of which is at least partially crosslinked with a curing agent and comprises a low-endotoxin alginic acid monovalent metal salt, the alginic acid monovalent metal salt in the first layer has a weight average molecular weight of 10,000 to 2,000,000, the alginic acid monovalent metal salt in the second layer has a weight average molecular weight of 1,000 to 1,000,000, the weight average molecular weights are measured by a GPC-MALS method after a decrosslinking treatment, and the weight average molecular weight of the alginic acid monovalent metal salt in the first layer is higher than that in the second layer.Type: GrantFiled: August 26, 2022Date of Patent: February 6, 2024Assignees: The University of Tokyo, Mochida Pharmaceutical Co., Ltd.Inventors: Taichi Ito, Seiichi Ohta, Norihiro Kokudo, Mitsuko Isaji, Satoshi Shimizu
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Publication number: 20230145308Abstract: An adhesion-preventing material having a high adhesion-preventing effect has been demanded. An adhesion-preventing material including a sterilized biocompatible sponge-like laminate, wherein the sponge-like laminate comprises a sponge-like first layer and a sponge-like second layer each of which is at least partially crosslinked with a curing agent and comprises a low-endotoxin alginic acid monovalent metal salt, the alginic acid monovalent metal salt in the first layer has a weight average molecular weight of 10,000 to 2,000,000, the alginic acid monovalent metal salt in the second layer has a weight average molecular weight of 1,000 to 1,000,000, the weight average molecular weights are measured by a GPC-MALS method after a decrosslinking treatment, and the weight average molecular weight of the alginic acid monovalent metal salt in the first layer is higher than that in the second layer.Type: ApplicationFiled: August 26, 2022Publication date: May 11, 2023Applicants: Mochida Pharmaceutical Co., Ltd., The University of TokyoInventors: Taichi ITO, Seiichi OHTA, Norihiro KOKUDO, Mitsuko ISAJI, Satoshi SHIMIZU
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Patent number: 11464597Abstract: [Problem] An adhesion-preventing material having a high adhesion-preventing effect has been demanded. [Solution] An adhesion-preventing material including a sterilized biocompatible sponge-like laminate, wherein the sponge-like laminate comprises a sponge-like first layer and a sponge-like second layer each of which is at least partially crosslinked with a curing agent and comprises a low-endotoxin alginic acid monovalent metal salt, the alginic acid monovalent metal salt in the first layer has a weight average molecular weight of 10,000 to 2,000,000, the alginic acid monovalent metal salt in the second layer has a weight average molecular weight of 1,000 to 1,000,000, the weight average molecular weights are measured by a GPC-MALS method after a decrosslinking treatment, and the weight average molecular weight of the alginic acid monovalent metal salt in the first layer is higher than that in the second layer.Type: GrantFiled: July 13, 2017Date of Patent: October 11, 2022Assignees: The University of Tokyo, Mochida Pharmaceutical Co., Ltd.Inventors: Taichi Ito, Seiichi Ohta, Norihiro Kokudo, Mitsuko Isaji, Satoshi Shimizu
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Publication number: 20190209260Abstract: [Problem] An adhesion-preventing material having a high adhesion-preventing effect has been demanded. [Solution] An adhesion-preventing material including a sterilized biocompatible sponge-like laminate, wherein the sponge-like laminate comprises a sponge-like first layer and a sponge-like second layer each of which is at least partially crosslinked with a curing agent and comprises a low-endotoxin alginic acid monovalent metal salt, the alginic acid monovalent metal salt in the first layer has a weight average molecular weight of 10,000 to 2,000,000, the alginic acid monovalent metal salt in the second layer has a weight average molecular weight of 1,000 to 1,000,000, the weight average molecular weights are measured by a GPC-MALS method after a decrosslinking treatment, and the weight average molecular weight of the alginic acid monovalent metal salt in the first layer is higher than that in the second layer.Type: ApplicationFiled: July 13, 2017Publication date: July 11, 2019Applicant: Mochida Pharmaceutical Co., Ltd.Inventors: Taichi ITO, Seiichi OHTA, Norihiro KOKUDO, Mitsuko ISAJI, Satoshi SHIMIZU
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Publication number: 20180008749Abstract: An object of the present invention is to provide an adhesion preventing material capable of preventing adhesion safely and efficiently. The present invention provides an adhesion preventing material comprised of a cell sheet containing mesothelial cells; an adhesion preventing method and organ regeneration promoting method each using the cell sheet containing mesothelial cells.Type: ApplicationFiled: September 20, 2017Publication date: January 11, 2018Inventors: Atsushi MIYAJIMA, Natsuko Inagaki, Fuyuki Inagaki, Norihiro Kokudo
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Publication number: 20170198260Abstract: An object of the present invention is to provide a method for differentiating mesodermal cells into mesothelium cells. The present invention provides a method for producing mesothelial cells, including a first culturing step of culturing mesodermal cells in a medium containing basic fibroblast growth factor (bFGF) and oncostatin M.Type: ApplicationFiled: May 25, 2015Publication date: July 13, 2017Inventors: Atsushi MIYAJIMA, Natsuko INAGAKI, Fuyuki INAGAKI, Norihiro KOKUDO
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Patent number: 9506102Abstract: A fluorescent probe for detecting pancreatic fluid containing a compound or salt thereof represented by formula (I) below. (In the formula, A represents an amino acid residue or N-substituted amino acid residue, with A forming an amide bond with the adjacent NH in the formula; R1 represents a hydrogen atom or 1 to 4 same or different substituent groups that bond with a benzene ring; R2, R3, R4, R5, R6, and R7 each independently represent a hydrogen atom, a hydroxyl group, an alkyl group, or a halogen atom; R8 and R9 each independently represent a hydrogen atom or an alkyl group; and X represents a C1-C3 alkylene group).Type: GrantFiled: May 29, 2013Date of Patent: November 29, 2016Assignee: THE UNIVERSITY OF TOKYOInventors: Yasuteru Urano, Masayo Sakabe, Tetsuo Nagano, Takeaki Ishizawa, Suguru Yamashita, Norihiro Kokudo, Mako Kamiya
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Publication number: 20160058917Abstract: An object of the present invention is to provide an adhesion preventing material capable of preventing adhesion safely and efficiently. The present invention provides an adhesion preventing material comprised of a cell sheet containing mesothelial cells; an adhesion preventing method and organ regeneration promoting method each using the cell sheet containing mesothelial cells.Type: ApplicationFiled: January 22, 2014Publication date: March 3, 2016Inventors: Atsushi MIYAJIMA, Natsuko INAGAKI, Fuyuki INAGAKI, Norihiro KOKUDO
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Publication number: 20150152469Abstract: [Problem] To provide a fluorescent probe capable of rapidly detecting and imaging with high sensitivity the presence of leakage of pancreatic fluid during or after surgery, and to furthermore provide a detection method and detection kit that use the fluorescent probe. [Solution] A fluorescent probe for detecting pancreatic fluid containing a compound or salt thereof represented by formula (I) below. (In the formula, A represents an amino acid residue or N-substituted amino acid residue, with A forming an amide bond with the adjacent NH in the formula; R1 represents a hydrogen atom or 1 to 4 same or different substituent groups that bond with a benzene ring; R2, R3, R4, R5, R6, and R7 each independently represent a hydrogen atom, a hydroxyl group, an alkyl group, or a halogen atom; R8 and R9 each independently represent a hydrogen atom or an alkyl group; and X represents a C1-C3 alkylene group.Type: ApplicationFiled: May 29, 2013Publication date: June 4, 2015Applicant: THE UNIVERSITY OF TOKYOInventors: Yasuteru Urano, Masayo Sakabe, Tetsuo Nagano, Takeaki Ishizawa, Suguru Yamashita, Norihiro Kokudo, Mako Kamiya
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Publication number: 20110218121Abstract: Provided are a method for detecting early-stage liver cancer and determining a risk of liver cancer by using blood collected from a patient with imposing a less burden on the patient; and a gene marker, a probe, a primer, and a reagent kit that can be used in the detection. A marker for diagnosis of acquiring liver cancer includes a polynucleotide that can detect all of the following methylated genes and a gene region: (1) human SALL3c gene, (2) human ECEL1 gene, and (3) SEQ ID NO: 6 (NT_037622.5, 1393863-1395863).Type: ApplicationFiled: October 29, 2008Publication date: September 8, 2011Applicant: THE UNIVERSITY OF TOKYOInventors: Takeaki Ishizawa, Norihiro Kokudo, Hirohide Yoshikawa, Yuko Shikauchi, Yaeko Murase