Abstract: A pharmaceutical composition comprising (i) an antibody-drug conjugate in which a drug-linker represented by the following formula (wherein A represents a connecting position to an antibody) is conjugated to the antibody via a thioether bond, (ii) a histidine buffer, (iii) sucrose or trehalose, and (iv) a surfactant; and a method of lyophilizing the pharmaceutical composition.

Abstract: A therapeutic agent for chronic arthritides diseases of childhood-related diseases, for example chronic arthritides diseases of childhood, Still's disease and the like, comprising an interleukin-6 (IL-6) antagonist as an active ingredient.

Abstract: A target object detection device is provided. The device includes a signal processor, a display unit, and a controller. The signal processor receives a reception signal generated based on an echo of an ultrasonic wave from a target object and generates echo data corresponding to a distance from a transmission source of the ultrasonic wave to the target object every time the ultrasonic wave is transmitted. The display unit has a display screen with a first side and a second side that is turnable in an axial direction perpendicular to the display screen, and displays an image on the display screen based on the echo data. The controller sets a range with respect to time at which the ultrasonic wave is transmitted, and outputs the echo data corresponding to the ultrasonic wave within the time range according to turning of the display screen.

Abstract: A therapeutic agent for chronic arthritides diseases of childhood-related diseases, for example chronic arthritides diseases of childhood, Still's disease and the like, comprising an interleukin-6 (IL-6) antagonist as an active ingredient.

Abstract: The present inventors studied the effects of inhibiting the IL-6 signaling pathway on muscle cell growth. As a result, they discovered that, administering an IL-6 inhibitor can promote the adhesion, proliferation, and differentiation of satellite cells and therefore muscle regeneration.

Abstract: A therapeutic agent for chronic arthritides diseases of childhood-related diseases, for example chronic arthritides diseases of childhood, Still's disease and the like, comprising an interleukin-6 (IL-6) antagonist as an active ingredient.

Abstract: The present invention provides a mesothelioma therapeutic agent containing an interleukin-6 (IL-6) antagonist such as antibody to IL-6 receptor (IL-6R), and a mesothelioma cell growth inhibitor containing an IL-6 antagonist such as antibody to IL-6R.

Abstract: To provide a preventive and/or therapeutic agent for vasculitis such as polyarteritis nodosa, the aortitis syndrome, and a vasculitis that is associated with immunological abnormalities, said agent comprising an interleukin-6 (IL-6) antagonist as an active ingredient.

Abstract: A target object detection device is provided. The device includes a signal processor, a display unit, and a controller. The signal processor receives a reception signal generated based on an echo of an ultrasonic wave from a target object and generates echo data corresponding to a distance from a transmission source of the ultrasonic wave to the target object every time the ultrasonic wave is transmitted. The display unit has a display screen with a first side and a second side that is turnable in an axial direction perpendicular to the display screen, and displays an image on the display screen based on the echo data. The controller sets a range with respect to time at which the ultrasonic wave is transmitted, and outputs the echo data corresponding to the ultrasonic wave within the time range according to turning of the display screen.

Abstract: To provide a preventive and/or therapeutic agent for vasculitis such as polyarteritis nodosa, the aortitis syndrome, and a vasculitis that is associated with immunological abnormalities, said agent comprising an interleukin-6 (IL-6) antagonist as an active ingredient.

Abstract: A method for treating psoriasis comprising an interleukin-6 (IL-6) antagonist such as, for example, an antibody against IL-6 receptor.

Abstract: A method for treating psoriatic arthritis comprising an interleukin-6 (IL-6) antagonist such as, for example, an antibody against IL-6 receptor.

Abstract: A blood vascular endothelial growth factor (VEGF) level-lowering agent comprising an interleukin-6 (IL-6) antagonist as an active ingredient.

Abstract: The present invention is directed to a lyophilized preparation which contains a synthetic quinolone antibacterial compound and, as a solo additive, a pH-adjusting agent, and which exhibits an excellent reconstituting property. The invention provides a method for producing a lyophilized preparation containing a synthetic quinolone antibacterial compound as an active ingredient, characterized by including, sequentially, cooling an aqueous solution containing a synthetic quinolone antibacterial compound and a pH-adjusting agent to yield a frozen product, elevating the temperature of the frozen product, and re-cooling the resultant to prepare the lyophilized preparation.

Abstract: This disclosure provides a fish finder, which includes a transmission module and a reception module, for outputting an ultrasonic wave underwater, receiving an echo, and outputting a reception signal corresponding to an intensity of the received echo, a control module for generating echo data corresponding to a depth based on the reception signal, a display module for displaying the echo data, and a user interface for receiving a user's operation. The control module causes the display module to display the echo data so that the echo data is displayed in two or more display screens. At least one display screen displays an area having a color different from a background color. A part of the echo data at a depth range corresponding to a height of the area is displayed in the other display screen so as to expand the echo data in a depth direction. The user interface specifies a position and a size of the area via the user's operation.

Abstract: A method for treating psoriatic arthritis comprising an interleukin-6 (IL-6) antagonist such as, for example, an antibody against IL-6 receptor.

Abstract: A therapeutic agent for chronic arthritides diseases of childhood-related diseases, for example chronic arthritides diseases of childhood, Still's disease and the like, comprising an interleukin-6 (IL-6) antagonist as an active ingredient.

Abstract: A therapeutic agent for chronic arthritides diseases of childhood-related diseases, for example chronic arthritides diseases of childhood, Still's disease and the like, comprising an interleukin-6 (IL-6) antagonist as an active ingredient.

Abstract: This disclosure provides a fish finder, which includes a transmission module and a reception module, for outputting an ultrasonic wave underwater, receiving an echo, and outputting a reception signal corresponding to an intensity of the received echo, a control module for generating echo data corresponding to a depth based on the reception signal, a display module for displaying the echo data, and a user interface for receiving a user's operation. The control module causes the display module to display the echo data so that the echo data is displayed in two or more display screens. At least one display screen displays an area having a color different from a background color. A part of the echo data at a depth range corresponding to a height of the area is displayed in the other display screen so as to expand the echo data in a depth direction. The user interface specifies a position and a size of the area via the user's operation.

Abstract: The present inventors studied the effects of inhibiting the IL-6 signaling pathway on muscle cell growth. As a result, they discovered that, administering an IL-6 inhibitor can promote the adhesion, proliferation, and differentiation of satellite cells and therefore muscle regeneration.