Abstract: The present disclosure concerns combination therapy for cancer that utilizes (i) an oncolytic virus; (ii) a virus comprising nucleic acid encoding an immunomodulatory factor; and (iii) at least one cell comprising a chimeric antigen receptor (CAR) specific for a cancer cell antigen. In particular embodiments, the virus comprises nucleic acid encoding an immunomodulatory factor comprises nucleic acid encoding IL-12 and/or antagonist anti-PD-L1 antibody.

Abstract: The present disclosure concerns combination therapy for cancer thatutilizes (i) an oncolytic virus; (ii) a virus comprising nucleic acid encoding an immunomodulatory factor; and (iii) at least one cell comprising a chimeric antigen receptor (CAR) specific for a cancer cell antigen. In particular embodiments, the virus comprises nucleic acid encoding an immunomodulatory factor comprises nucleic acid encoding IL-12 and/or antagonist anti-PD-L1 antibody.

Abstract: The present disclosure concerns combination therapy for cancer that utilizes (i) an oncolytic virus; (ii) a virus comprising nucleic acid encoding an immunomodulatory factor; and (iii) at least one cell comprising a chimeric antigen receptor (CAR) specific for a cancer cell antigen. In particular embodiments, the virus comprises nucleic acid encoding an immunomodulatory factor comprises nucleic acid encoding IL-12 and/or antagonist anti-PD-L1 antibody.

Abstract: Magnets are disposed between adjacent first claw portions and second claw portions so as to protrude toward a second end in an axial direction from tips of the first claw portions and so as to protrude toward a first end in the axial direction from tips of the second claw portions, magnet holding members include a base portion that covers a radially outer surface of the magnets, and the base portion includes a high magnetic resistance portion that is disposed in a direction that is perpendicular to a direction from the first claw portions toward the second claw portions and parallel to the radially outer surface of the magnets so as to cross a magnetic path from the first claw portions toward the second claw portions in a region between the adjacent first claw portions and second claw portions.

Abstract: The present disclosure concerns combination therapy for cancer that utilizes (i) an oncolytic virus; (ii) a virus comprising nucleic acid encoding an immunomodulatory factor, and (iii) at least one cell comprising a chimeric antigen receptor (CAR) specific for a cancer cell antigen. In particular embodiments, the virus comprises nucleic acid encoding an immunomodulatory factor comprises nucleic acid encoding IL-12 and/or antagonist anti-PD-L1 antibody.

Abstract: Embodiments of the disclosure concern cell therapy methods and compositions utilizing cells expressing at least a chimeric TGF? receptor including the exodomain of a TGF?II receptor and an endodomain that is not from TGF? receptor, thereby converting the negative signal of TGF? for T cell proliferation into a T cell activation signal. In at least certain aspects, cells harboring the chimeric TGF? receptor also harbor one or more chimeric antigen receptors.

Abstract: Embodiments of the disclosure concern cell therapy methods and compositions utilizing cells expressing at least a chimeric TGF? receptor including the exodomain of a TGF?II receptor and an endodomain that is not from TGF? receptor, thereby converting the negative signal of TGF? for T cell proliferation into a T cell activation signal. In at least certain aspects, cells harboring the chimeric TGF? receptor also harbor one or more chimeric antigen receptors.

Abstract: The present disclosure concerns combination therapy for cancer that utilizes (i) an oncolytic virus; (ii) a virus comprising nucleic acid encoding an immunomodulatory factor, and (iii) at least one cell comprising a chimeric antigen receptor (CAR) specific for a cancer cell antigen. In particular embodiments, the virus comprises nucleic acid encoding an immunomodulatory factor comprises nucleic acid encoding IL-12 and/or antagonist anti-PD-L1 antibody.

Abstract: A rotary electric machine of the present invention includes, inside a housing, a rotor and a stator that are concentric with each other. The stator has a plurality of coil portions in a circumferential direction. In the stator, a first flow channel and a second flow channel, through which cooling water flows, are provided along the plurality of coil portions, each of the channels having one end connected to a flow channel inlet and the other end connected to a flow channel outlet. The lengths of the first flow channel and the second flow channel are mutually different. A temperature detection element is provided in a coil portion on a high temperature side among the coil portions positioned along the first flow channel and the coil portions positioned along the second flow channel.

Abstract: Embodiments of the disclosure include methods and compositions that allow for development of efficient chimeric antigen receptors (CARs) by selecting appropriate spacer content and/or length by balancing the effects of tonic signaling with the efficacy of antigen recognition for the spacer. In specific embodiments, the CH3 domain from IgG2 is utilized as a spacer. In specific embodiments, T cell metabolic activity is utilized as a measure of tonic signaling to facilitate determination of suitable CAR constructs. In other embodiments, cells bearing chimeric Fc receptor target molecules are utilized to target Fc gamma receptor (FcR)-bearing for the purpose of their destruction.

Abstract: In a mechanically and electrically integrated driving apparatus, a common coolant flow channel for cooling a motor unit and an inverter unit is disposed inside a wall portion of a frame unit. Power modules are placed in close contact with an inner wall surface of the frame unit. A bracket that is separate from the frame unit is fitted into the frame unit. A space inside the frame unit is divided by the bracket into: a space in which the motor unit is housed; and a space in which the inverter unit is housed.

Abstract: Magnets are disposed between adjacent first claw portions and second claw portions so as to protrude toward a second end in an axial direction from tips of the first claw portions and so as to protrude toward a first end in the axial direction from tips of the second claw portions, magnet holding members include a base portion that covers a radially outer surface of the magnets, and the base portion includes a high magnetic resistance portion that is disposed in a direction that is perpendicular to a direction from the first claw portions toward the second claw portions and parallel to the radially outer surface of the magnets so as to cross a magnetic path from the first claw portions toward the second claw portions in a region between the adjacent first claw portions and second claw portions.

Abstract: In an inverter integrated motor apparatus, a cylindrical base frame has an inverter unit accommodating section. The inverter unit has a plurality of control substrates and a plurality of power modules which are provided on the control substrates. In the inverter unit accommodating section, a plurality of openings are provided at intervals in the circumferential direction. A rib section is formed between mutually adjacent openings. The openings are covered by the plurality of heat sinks. The power modules and control substrates are disposed on the inside of the heat sinks.

Abstract: A rotary electric machine of the present invention includes, inside a housing, a rotor and a stator that are concentric with each other. The stator has a plurality of coil portions in a circumferential direction. In the stator, a first flow channel and a second flow channel, through which cooling water flows, are provided along the plurality of coil portions, each of the channels having one end connected to a flow channel inlet and the other end connected to a flow channel outlet. The lengths of the first flow channel and the second flow channel are mutually different. A temperature detection element is provided in a coil portion on a high temperature side among the coil portions positioned along the first flow channel and the coil portions positioned along the second flow channel.

Abstract: In the electric power converting apparatus, a frame unit is configured by mounting an inner frame into an outer frame, brackets are disposed on two axial ends of the frame unit, an annular liquid cooling jacket is configured between the inner frame and the outer frame, the inner frame is configured into a tubular shape by bending a plurality of base members that are linked consecutively at thin linking portions between the base members, and butting together the base members that are positioned at two ends in a direction of linking, the power modules are mounted to respective side wall surfaces of the inner frame that face radially inward, and sealing members that seal the liquid cooling jacket are respectively disposed in the butted portion of the base members, and between the frame unit and the bracket.

Abstract: In the electric power converting apparatus, a frame unit is configured by mounting an inner frame into an outer frame, brackets are disposed on two axial ends of the frame unit, an annular liquid cooling jacket is configured between the inner frame and the outer frame, the inner frame is configured into a tubular shape by bending a plurality of base members that are linked consecutively at thin linking portions between the base members, and butting together the base members that are positioned at two ends in a direction of linking, the power modules are mounted to respective side wall surfaces of the inner frame that face radially inward, and sealing members that seal the liquid cooling jacket are respectively disposed in the butted portion of the base members, and between the frame unit and the bracket.

Abstract: In a mechanically and electrically integrated rotary electric machine, a motor portion and an inverter portion are inserted inside a cylindrical frame. The motor portion has a plurality of coils. The inverter portion has a plurality of switching elements. The coils and the switching elements are electrically connected by a connector. The connector has: an end portion connector that distributes sinusoidal electric currents from the switching elements to the respective coils; and a plurality of axial connectors that direct the sinusoidal electric currents from the switching elements to the end portion connector. The end portion connector is disposed on an end portion of the motor portion near an output shaft. The axial connectors are disposed parallel to an axial direction of the frame so as to pass from the switching elements through a mounted region of the motor portion.

Abstract: In a rotary electric machine, first inclined surfaces that intersect a plane that includes a central axis of a shaft at a predetermined angle are disposed radially outside gaps between coil ends of circumferentially adjacent concentrated winding coils, and cooling air that is blown out from a cooling fan and has flowed radially outward through the gaps between the coil ends is converted into an axially outward flow by the first inclined surfaces.

Abstract: In an inverter integrated motor apparatus, a cylindrical base frame has an inverter unit accommodating section. The inverter unit has a plurality of control substrates and a plurality of power modules which are provided on the control substrates. In the inverter unit accommodating section, a plurality of openings are provided at intervals in the circumferential direction. A rib section is formed between mutually adjacent openings. The openings are covered by the plurality of heat sinks. The power modules and control substrates are disposed on the inside of the heat sinks.

Abstract: In a mechanically and electrically integrated rotary electric machine, a motor portion and an inverter portion are inserted inside a cylindrical frame. The motor portion has a plurality of coils. The inverter portion has a plurality of switching elements. The coils and the switching elements are electrically connected by a connector. The connector has: an end portion connector that distributes sinusoidal electric currents from the switching elements to the respective coils; and a plurality of axial connectors that direct the sinusoidal electric currents from the switching elements to the end portion connector. The end portion connector is disposed on an end portion of the motor portion near an output shaft. The axial connectors are disposed parallel to an axial direction of the frame so as to pass from the switching elements through a mounted region of the motor portion.