Patents by Inventor Norihito Kawashita

Norihito Kawashita has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • NOVEL EPITOPE AND MECHANISM OF ANTIGEN-ANTIBODY INTERACTION IN AN INFLUENZA VIRUS
    Publication number: 20140086927
    Abstract: Antibodies (Abs) play roles in protection against influenza. Neutralizing Abs either inhibit the binding of hemagglutinin (HA) to cellular receptors or prevent the conformational change of HA induced by low pH. The former Ab binds to the regions near the sialic acid-binding pocket on the globular head formed by HA1 and generally shows narrow strain specificity. The latter Ab binds to the stem region formed mainly by HA2 and shows broad strain specificity. We isolated a broadly neutralizing Ab against H3N2 viruses. X-ray analysis of the HA/Ab complex indicated that the Ab binds to the valley formed by two neighboring HA monomers at the side of the globular head. The Ab shows neutralizing activity by preventing the conformational change of HA induced at low pH.
    Type: Application
    Filed: September 24, 2013
    Publication date: March 27, 2014
    Applicants: Fujita Health University, The Research Foundation for Microbial Diseases of Osaka University, Osaka University
    Inventors: Yoshikazu Kurosawa, Yoshitaka Iba, Nobuko Ohshima, Shigeyuki Yokoyama, Mikako Shirouzu, Yoshifumi Fujii, Tomomi Sumida, Kazuyoshi Ikuta, Shota Nakamura, Norihito Kawashita, Mitsuhiro Nishimura, Akifumi Yamashita, Yoshinobu Okuno, Ritsuko Kubota-Koketsu, Masahiro Okubo
  • An Antigenic Peptide Derived From Influenza Virus And A Method For Selecting Anti-Influenza Virus Antibody
    Publication number: 20120156242
    Abstract: Antigenic peptides are provided that can be used to induce global neutralizing antibodies, or antibodies reactive against a wide range of influenza A virus strains. The antigenic peptide can correspond to SEQ ID NO: 34 (EKEVLVLWG), SEQ ID NO: 2 (KFDKLYIWG), SEQ ID NO: 71(QEDLLVLWG), SEQ ID NO: 51 (EGRINYYWTLLEP), SEQ ID NO: 3 (PSRISIYWTIVKP), and/or SEQ ID NO: 82 (SGRMEFFWTILKP).
    Type: Application
    Filed: June 16, 2010
    Publication date: June 21, 2012
    Inventors: Kazuyoshi Ikuta, Ritsuko Koketsu, Akifumi Yamashita, Norihito Kawashita, Mikihiro Yunoki, Yoshinobu Okuno, Shoji Ideno, Motoki Kuhara