Patents by Inventor Norihito Kuno
Norihito Kuno has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11443851Abstract: In order to determine, in a cancer test using nematodes, whether or not the nematodes used in the cancer test are adequate, the present invention is characterized in that after a plate on which a urine from a subject and the nematode are set is placed, a cancer test apparatus performs imaging for quality assay of the nematode during the initial two minutes; an analysis apparatus determines a quality of the nematode using the imaging result; after taxis of the nematode is completed, the cancer test apparatus performs imaging for cancer test assay by the nematode; and the analysis apparatus determines the presence or absence of a cancer in the subject using the imaging result.Type: GrantFiled: November 30, 2015Date of Patent: September 13, 2022Inventors: Minoru Sakairi, Masakazu Sugaya, Koichi Terada, Taku Nakamura, Norihito Kuno
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Patent number: 11249069Abstract: A cancer analysis system includes, so as to perform an efficient image analysis in a cancer screening test using nematodes: a light source unit that irradiates a plate on which nematodes and a urine sample are plotted, from below; a photographing unit that takes an image of the plate irradiated by the light source unit; and an analyzer that analyzes the image taken by the photographing unit. The analyzer: couples a prescribed number of pixels in the image into a larger number of pixels thereof; and performs a chemotaxis assay of the nematodes based on a time variation of information on a luminous center of gravity of the image.Type: GrantFiled: February 28, 2017Date of Patent: February 15, 2022Inventors: Minoru Sakairi, Masakazu Sugaya, Koichi Terada, Taku Nakamura, Norihito Kuno
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Publication number: 20190079071Abstract: A cancer analysis system includes, so as to perform an efficient image analysis in a cancer screening test using nematodes: a light source unit that irradiates a plate on which nematodes and a urine sample are plotted, from below; a photographing unit that takes an image of the plate irradiated by the light source unit; and an analyzer that analyzes the image taken by the photographing unit. The analyzer: couples a prescribed number of pixels in the image into a larger number of pixels thereof; and performs a chemotaxis assay of the nematodes based on a time variation of information on a luminous center of gravity of the image.Type: ApplicationFiled: February 28, 2017Publication date: March 14, 2019Inventors: Minoru SAKAIRI, Masakazu SUGAYA, Koichi TERADA, Taku NAKAMURA, Norihito KUNO
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Patent number: 10190088Abstract: A system for culturing a photosynthetic organism such as a microalga has a liquid storage vessel for storing a liquid that absorbs more light in a short-wavelength range than light in a long-wavelength range, a culture vessel for storing a culture solution containing a photosynthetic organism to be cultured and disposed in the liquid storage vessel, a light quantity measuring unit for measuring the quantity of light that the culture vessel receives and a liquid depth controlling unit for controlling the liquid depth from the surface of the light-absorbing solution to the culture vessel based on the measurement result of the light quantity measuring unit. The light quantity measuring unit measures quantities of light which the culture vessel receives separately for different wavelength ranges.Type: GrantFiled: February 27, 2013Date of Patent: January 29, 2019Assignee: Hitachi, Ltd.Inventors: Norihito Kuno, Hiroko Tada
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Publication number: 20180313839Abstract: In order to determine, in a cancer test using nematodes, whether or not the nematodes used in the cancer test are adequate, the present invention is characterized in that after a plate on which a urine from a subject and the nematode are set is placed, a cancer test apparatus performs imaging for quality assay of the nematode during the initial two minutes; an analysis apparatus determines a quality of the nematode using the imaging result; after taxis of the nematode is completed, the cancer test apparatus performs imaging for cancer test assay by the nematode; and the analysis apparatus determines the presence or absence of a cancer in the subject using the imaging result.Type: ApplicationFiled: November 30, 2015Publication date: November 1, 2018Inventors: Minoru SAKAIRI, Masakazu SUGAYA, Koichi TERADA, Taku NAKAMURA, Norihito KUNO
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Patent number: 9834806Abstract: A disposable microbe-collecting carrier cartridge and a carrier treating apparatus which efficiently convert microbes collected on a carrier into a solution and prevent variations in the amount of retrieval of microbes upon concentration on a filter are provided. A cartridge formed of an upper lid having a plurality of through holes, a container in an inverted-cone shape having both of a liquid storage sink unit having a filter at the bottom and an air suction path, and a support base for setting up a thermoplastic carrier, and a carrier treating apparatus formed of a dispensing nozzle for liquid supply, a liquid supply mechanism, a liquid heating mechanism, and a suction pump for filtration are prepared. Warm water is supplied onto the filter set up on a bottom surface of the inverted-cone-shaped. The contact with the warm water causes the carrier to be solated filtered through the filter.Type: GrantFiled: June 25, 2009Date of Patent: December 5, 2017Assignee: HITACHI PLANT SERVICES CO., LTD.Inventors: Hideyuki Noda, Masahiro Okanojo, Kenko Uchida, Norihito Kuno
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Publication number: 20160215224Abstract: As one aspect of the present invention, a chemical substance production system includes a first liquid reaction system that generates a first chemical substance, a second liquid reaction system that generates a second chemical substance, and a first membrane that is provided between the first liquid reaction system and the second liquid reaction system, wherein the second liquid reaction system causes a chemical reaction of the first chemical substance transferred from the first liquid reaction system to the second liquid reaction system through the first membrane, thereby generating the second chemical substance. According to this, a fuel production system that efficiently removes contaminants occurring in an extraction step when producing fuel derived from an alga or the like is provided.Type: ApplicationFiled: August 28, 2013Publication date: July 28, 2016Inventors: Hiroko TADA, Nami SUGITA, Norihito KUNO
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Publication number: 20160200640Abstract: In a reaction between a biomolecule and a radioactive agent precursor, the amount of a component of a radioactive agent precursor before the reaction and the amount of a component contained in a reaction mixture in a reaction process in which the reaction is performed at a predetermined biomolecule concentration are measured, a reaction rate constant is calculated from the information of the obtained amounts of the components, a reaction rate constant when the biomolecule concentration is changed is calculated, a reaction time, a specific radioactivity, and a radioactivity level of an objective substance at each biomolecule concentration are predicted, and synthesis is performed under a reaction condition under which the highest specific radioactivity is obtained among the reaction conditions satisfying the synthesis requirements.Type: ApplicationFiled: August 28, 2013Publication date: July 14, 2016Inventors: Naomi MANRI, Norihito KUNO
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Publication number: 20160010050Abstract: A system for culturing a photosynthetic organism such as a microalga has a liquid storage vessel for storing a liquid that absorbs more light in a short-wavelength range than light in a long-wavelength range, a culture vessel for storing a culture solution containing a photosynthetic organism to be cultured and disposed in the liquid storage vessel, a light quantity measuring unit for measuring the quantity of light that the culture vessel receives and a liquid depth controlling unit for controlling the liquid depth from the surface of the light-absorbing solution to the culture vessel based on the measurement result of the light quantity measuring unit. The light quantity measuring unit measures quantities of light which the culture vessel receives separately for different wavelength ranges.Type: ApplicationFiled: February 27, 2013Publication date: January 14, 2016Applicant: Hitachi, Ltd.Inventors: Norihito KUNO, Hiroko TADA
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Publication number: 20150068627Abstract: An actuator device includes a pin that performs translatory motion along a groove of a cam to which a three-way stopcock is connected, the cam that performs rotary motion, and a control unit that causes the pin to perform the translatory motion along an extending direction of the cam, and rotates the cam with respect to a central axis of rotation, thereby to divert a passage of the three-way stopcock. A first, second, third, and fourth grooves that form the groove have a linked shape. Directions of inclinations of the first inclination angle and the third inclination angle are opposite with respect to the central axis, and directions of inclinations of the second inclination angle and the fourth inclination angle are opposite with respect to the central axis.Type: ApplicationFiled: September 5, 2014Publication date: March 12, 2015Inventors: Kunio HARADA, Akihiro FURUKAWA, Masakazu SUGAYA, Norihito KUNO, Hisashi MURATA
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Publication number: 20110183371Abstract: A disposable microbe-collecting carrier cartridge and a carrier treating apparatus which efficiently convert microbes collected on a carrier into a solution and prevent variations in the amount of retrieval of microbes upon concentration on a filter are provided. A cartridge formed of an upper lid having a plurality of through holes, a container in an inverted-cone shape having both of a liquid storage sink unit having a filter at the bottom and an air suction path, and a support base for setting up a thermoplastic carrier, such as gelatin, and a carrier treating apparatus formed of a dispensing nozzle for liquid supply, a liquid supply mechanism, a liquid heating mechanism, and a suction pump for filtration are prepared. Warm water is supplied onto the filter set up on a bottom surface of the inverted-cone-shaped container and is stored in the liquid storage sink, thereby causing the carrier to make contact with the warm water.Type: ApplicationFiled: June 25, 2009Publication date: July 28, 2011Inventors: Hideyuki Noda, Masahiro Okanojo, Kenko Uchida, Norihito Kuno
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Patent number: 7888111Abstract: An object of the present invention is to provide a cell culture vessel which is simple in structure and easy to handle, and is capable of preventing damage to the cells when separated, promoting transport of nutrients and excretion of effete matter, and elevating the culturing efficiency improving effect by the structural features. In order to attain the above object, there is provided a cell culture vessel including a culture section provided with a plurality of projections having an equivalent diameter smaller than the cells to be cultured and the culture section side walls enclosing the culture section, wherein the distance between an arbitrary position on the culture section/side wall boundary line and the nearest projection is smaller than the diameter of the cells to be cultured. The effect of the projections in the vessel given to the cultured cells is enhanced.Type: GrantFiled: November 9, 2009Date of Patent: February 15, 2011Assignee: Hitachi, Ltd.Inventors: Kosuke Kuwabara, Akihiro Miyauchi, Norihito Kuno
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Patent number: 7737268Abstract: Disclosure is a method of separately recovering deoxyribonucleic acid and ribonucleic acid from a biological sample solution. They are separated and recovered from a single biological sample by controlling pH values, temperature, and/or concentration of cationic ions of a nucleic acid sample solution containing a caotropic agent. It is possible to easily and safely separate and recover deoxyribonucleic acid and ribonucleic acid from the single biological sample.Type: GrantFiled: May 19, 2004Date of Patent: June 15, 2010Assignee: Hitachi High-Technologies CorporationInventors: Norihito Kuno, Kenko Uchida
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Patent number: 7691625Abstract: An object of the present invention is to provide a cell culture vessel which is simple in structure and easy to handle, and is capable of preventing damage to the cells when separated, promoting transport of nutrients and excretion of effete matter, and elevating the culturing efficiency improving effect by the structural features. In order to attain the above object, there is provided a cell culture vessel including a culture section provided with a plurality of projections having an equivalent diameter smaller than the cells to be cultured and the culture section side walls enclosing the culture section, wherein the distance between an arbitrary position on the culture section/side wall boundary line and the nearest projection is smaller than the diameter of the cells to be cultured. The effect of the projections in the vessel given to the cultured cells is enhanced.Type: GrantFiled: May 26, 2006Date of Patent: April 6, 2010Assignee: Hitachi, Ltd.Inventors: Kosuke Kuwabara, Akihiro Miyauchi, Norihito Kuno
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Publication number: 20100055779Abstract: An object of the present invention is to provide a cell culture vessel which is simple in structure and easy to handle, and is capable of preventing damage to the cells when separated, promoting transport of nutrients and excretion of effete matter, and elevating the culturing efficiency improving effect by the structural features. In order to attain the above object, there is provided a cell culture vessel including a culture section provided with a plurality of projections having an equivalent diameter smaller than the cells to be cultured and the culture section side walls enclosing the culture section, wherein the distance between an arbitrary position on the culture section/side wall boundary line and the nearest projection is smaller than the diameter of the cells to be cultured. The effect of the projections in the vessel given to the cultured cells is enhanced.Type: ApplicationFiled: November 9, 2009Publication date: March 4, 2010Inventors: Kosuke Kuwabara, Akihiro Miyauchi, Norihito Kuno
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Publication number: 20090111114Abstract: A method to extract RNA with high purity from biological materials containing RNA in a safe, rapid, and simple procedure and a method to analyze it are provided. The procedure includes the steps of mixing a biological material containing RNA with a predetermined concentration of a chaotropic agent and a predetermined concentration of an organic solvent, allowing the mixed solution to contact a nucleic acid-binding solid phase, washing the nucleic-acid binding solid-phase to which RNA is bound, and eluting RNA from the nucleic-acid binding solid-phase having the bound RNA. Furthermore, the obtained RNA is analyzed by reverse transcriptase-polymerase chain reaction (RT-PCR) or the like.Type: ApplicationFiled: October 14, 2008Publication date: April 30, 2009Inventors: Yoshihiro Yamashita, Toshinari Sakurai, Norihito Kuno, Kenko Uchida, Toshiaki Yokobayashi
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Publication number: 20060281172Abstract: An object of the present invention is to provide a cell culture vessel which is simple in structure and easy to handle, and is capable of preventing damage to the cells when separated, promoting transport of nutrients and excretion of effete matter, and elevating the culturing efficiency improving effect by the structural features. In order to attain the above object, there is provided a cell culture vessel including a culture section provided with a plurality of projections having an equivalent diameter smaller than the cells to be cultured and the culture section side walls enclosing the culture section, wherein the distance between an arbitrary position on the culture section/side wall boundary line and the nearest projection is smaller than the diameter of the cells to be cultured. The effect of the projections in the vessel given to the cultured cells is enhanced.Type: ApplicationFiled: May 26, 2006Publication date: December 14, 2006Inventors: Kosuke Kuwabara, Akihiro Miyauchi, Norihito Kuno
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Publication number: 20060115381Abstract: An analyzer to carry out a reaction with efficiency is provided. A substrate and a cover member having a concave portion to form a space for retaining a reaction solution are constructed of deformable material, the cover member is deformed by exerting a force externally of the cover member, and the reaction solution introduced into the space for reaction is moved within the space by this deformation, thereby allowing the reaction solution to be stirred within the space. Enhancement of signal intensities is achieved by improvement of reaction efficiency due to mixing. Further, uniform mixing can be achieved over the entire region within the space because an arbitrary location of the cover member can be deformed.Type: ApplicationFiled: August 3, 2005Publication date: June 1, 2006Inventors: Norihito Kuno, Masayoshi Ishibashi
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Publication number: 20050288867Abstract: In order to detect the mis-operation of cells or tissues in a culturing step and other working steps to prevent erroneous use in treatment of cultured cell and tissues besides those of the cell donor, a genetic information, held by a cell or tissue, is used as a cell tissue information, which is inseparable from the cell tissue itself and enables individual identification of the cell donor, that is, identification of the origin of the cell or tissue subject to a culture process, and the cell tissue information before and after culturing are compared and collated.Type: ApplicationFiled: June 27, 2005Publication date: December 29, 2005Inventor: Norihito Kuno
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Publication number: 20050123965Abstract: A method to extract RNA with high purity from biological materials containing RNA in a safe, rapid, and simple procedure and a method to analyze it are provided. The procedure includes the steps of mixing a biological material containing RNA with a predetermined concentration of a chaotropic agent and a predetermined concentration of an organic solvent, allowing the mixed solution to contact a nucleic acid-binding solid phase, washing the nucleic-acid binding solid-phase to which RNA is bound, and eluting RNA from the nucleic-acid binding solid-phase having the bound RNA. Furthermore, the obtained RNA is analyzed by reverse transcriptase-polymerase chain reaction (RT-PCR) or the like.Type: ApplicationFiled: November 5, 2004Publication date: June 9, 2005Inventors: Yoshihiro Yamashita, Toshinari Sakurai, Norihito Kuno, Kenko Uchida, Toshiaki Yokobayashi