Abstract: The present invention relates to pharmaceutical compositions for use in the treatment or prevention of a C5-related disease and methods for treating or preventing a C5-related disease. The present invention further relates to dosages and administrations of anti-C5 antibody or pharmaceutical compositions containing the anti-C5 antibody.

Abstract: The present invention provides a combination of two or more isolated or purified anti-C5 antibodies, wherein the isolated or purified anti-C5 antibodies bind to an epitope within the beta chain or alpha chain of C5 and wherein the isolated or purified anti-C5 antibodies to be combined do not compete with each other for binding to the epitope. Methods of using the combination for treating an individual having a complement-mediated disease or condition which involves excessive or uncontrolled activation of C5, or for enhancing the clearance of C5 from plasma in an individual, are also provided.

Abstract: A decorative film that exhibits visual effects such as, e.g., stereoscopic effect, luxurious feel, and the like; and can also exhibit complex flip-flop properties that have expansion, depth, fluctuation, and the like, and whereby a pattern can be made visible or invisible depending on the viewing angle. In one embodiment, the decorative film can include, in order, a base layer and, adjacent to the base layer, a brightening layer having a concavo-convex surface; or a brightening base layer including a brightening material and having a concavo-convex surface; adjacent to the brightening layer or the brightening base layer, a transparent resin layer; and, adjacent to the transparent resin layer, a semi-transparent metallic layer.

Abstract: The present invention relates to pharmaceutical compositions for use in the treatment or prevention of a C5-related disease and methods for treating or preventing a C5-related disease. The present invention further relates to dosages and administrations of anti-C5 antibody or pharmaceutical compositions containing the anti-C5 antibody.

Abstract: A decorative film that can handle various adherend shapes and application methods and has a visual effect that changes according to viewing angle. The decorative film of one embodiment includes a substrate layer, a photoluminescent layer that is adjacent to the substrate layer and has an unevenly-shaped surface, a transparent resin layer adjacent to the photoluminescent layer, and an outermost layer. A storage elastic modulus of at least the substrate layer or the transparent resin layer is 1×106 Pa to 1.5×108 Pa in a temperature range of 100° C. to 150° C. when measured under conditions of a frequency of 10 Hz and a shearing mode.

Abstract: The present invention relates to pharmaceutical compositions for use in the treatment or prevention of a C5-related disease and methods for treating or preventing a C5-related disease. The present invention further relates to dosages and administrations of anti-C5 antibody or pharmaceutical compositions containing the anti-C5 antibody.

Abstract: A decorative film that exhibits visual effects such as, e.g., stereoscopic effect, luxurious feel, and the like; and can also exhibit complex flip-flop properties that have expansion, depth, fluctuation, and the like, and whereby a pattern can be made visible or invisible depending on the viewing angle. In one embodiment, the decorative film can include, in order, a base layer and, adjacent to the base layer, a brightening layer having a concavo-convex surface; or a brightening base layer including a brightening material and having a concavo-convex surface; adjacent to the brightening layer or the brightening base layer, a transparent resin layer; and, adjacent to the transparent resin layer, a semi-transparent metallic layer.

Abstract: The present invention provides a combination of two or more isolated or purified anti-C5 antibodies, wherein the isolated or purified anti-C5 antibodies bind to an epitope within the beta chain or alpha chain of C5 and wherein the isolated or purified anti-C5 antibodies to be combined do not compete with each other for binding to the epitope. Methods of using the combination for treating an individual having a complement-mediated disease or condition which involves excessive or uncontrolled activation of C5, or for enhancing the clearance of C5 from plasma in an individual, are also provided.

Abstract: A decorative film that can handle various adherend shapes and application methods and has a visual effect that changes according to viewing angle. The decorative film of one embodiment includes a substrate layer, a photoluminescent layer that is adjacent to the substrate layer and has an unevenly-shaped surface, a transparent resin layer adjacent to the photoluminescent layer, and an outermost layer. A storage elastic modulus of at least the substrate layer or the transparent resin layer is 1×106 Pa to 1.5×108 Pa in a temperature range of 100° C. to 150° C. when measured under conditions of a frequency of 10 Hz and a shearing mode.

Abstract: The present invention provides a fastener which does not generate noise when it is engaged to an article and vibration is applied thereto.The fastener comprises a base portion, a stem portion implanted and interconnected to the base portion in a spaced-apart relationship by a predetermined distance from the base portion, and a head portion interconnected to the distal end of the base portion. At least a part of the stem portion or the head portion comprises (1) a polyphase polymer material having a first polymer resin and a second polymer resin, or (2) a polymer resin that increases the flexural modulus of the fastener.Since the fastener does not generate noise during vibration, it is useful as a fastener particularly for fitting automobile components together.

Abstract: To provide an interengaging fastener member which can enhance the disengagement force, while does not increase an engagement force required for an interengagement process. The fastener member 10 includes a base 12 and a plurality of headed stems 14. Each headed stem 14 includes a stem 16 adjoining and projecting orthogonally from the surface of base 12, and a head 18 formed at the end of the stem 16. The head 18 is provided with a bottom surface 20 adjacent to the stem 16 and extending outward from outer periphery of the stem 16, and an apex 24 arranged at an opposite side of the bottom surface 20 from the stem 16. The engagement force reducing means may take the form of, for example, one or more grooves formed in each head, or an undercut formed in each headed stem in the area where the head adjoins the stem.

Abstract: An interengaging fastener member having a base with a flexibility for conforming to the curved objective surface, without damaging a function for supporting headed stems. A fastener member 10 is provided with a base 12 and a plurality of headed stems 14 arranged on the base 12. The headed stem 14 has a stem 16 projecting substantially upright from the base 12, and a head 18 connected to the end of the stem 16. The base 12 includes a plate layer 26 having a first major surface 20, and a fabric layer 30 bonded to a surface opposite to the first major surface 20. The plate layer 26 is connected to proximal ends 22 of the stems 16 of the headed stems 14 by integral molding process. The plate layer 26 and the fabric layer 30 are bonded together in an injection molding process for the plate layer 26.

Abstract: To provide an interengaging fastener member which can enhance the disengagement force, while does not increase an engagement force required for an interengagement process. The fastener member 10 includes a base 12 and a plurality of headed stems 14. Each headed stem 14 includes a stem 16 adjoining and projecting orthogonally from the surface of base 12, and a head 18 formed at the end of the stem 16. The head 18 is provided with a bottom surface 20 adjacent to the stem 16 and extending outward from outer periphery of the stem 16, and an apex 24 arranged at an opposite side of the bottom surface 20 from the stem 16. The engagement force reducing means may take the form of, for example, one or more grooves formed in each head, or an undercut formed in each headed stem in the area where the head adjoins the stem.

Abstract: A method making an affixation member including a body for affixation to a surface of a structure and means for fastening the body to the surface. The fastening means including an interengaging fastener member which has a base secured to the body and a plurality of headed stems arranged on the base. The fastening means is formed by flowing molten material into a base mold, a destructible stem mold and a head mold. The base mold and head mold are separated, and the destructible stem mold and the molded interengaging fastener member are placed within a cavity of a body mold. An affixation member fixedly supporting the interengaging fastener member is molded in the cavity of the body mold. The body mold is separated from the molded affixation member, and the stem mold is destructibly removed from the interengaging fastener member fixedly supported on the molded affixation member.

Abstract: A fastener member is disclosed, having a plurality of headed stems adjoining and projecting from a base. The headed stems are arranged in a pattern on the base, which pattern tends to increase the disengagement force in the shear direction.

Abstract: An interengaging fastener is provided including two fastener members and structure for locating one fastener member with respect to the other fastener member. In one embodiment, the locating structure includes a protrusion extending from one fastener member and an opening formed in the other fastener member.

Abstract: Release liners comprising support sheet and face layer, the face layer comprising one or more of the following: a copolymer of ethylene and at least one polar commonomer, or a copolymer of propylene and at least one polar comonomer, or blends of such copolymers. Such release liners provide low temperature shock resistance and smooth, substantially uniform release characteristics when applied to acrylic pressure-sensitive adhesives.