Patents by Inventor Noriko Tomiyoshi

Noriko Tomiyoshi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Process for the preparation of etoposide phosphate and intermediate thereof
    Patent number: 5637680
    Abstract: An etoposide phosphate represented by the formula ##STR1## is prepared by blocking the hydroxyl groups of the saccharide moiety of etoposide with halogenoacetyl groups, thereafter phosphorylating the 4'-position, and removing the halogenoacetyl groups from the obtained phosphate in the presence of an amine. This process can give the objective etoposide phosphate in a higher yield than that of the prior art to enable the industrial mass-production thereof.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: June 10, 1997
    Assignee: Nippon Kayaku Kabushiki Kaisha
    Inventors: Yoshinobu Miyazawa, Hitoshi Sato, Hiroshi Yoshikawa, Kouichi Ohkawa, Noriko Tomiyoshi
  • Etoposide phosphate and preparative intermediates
    Patent number: 5606039
    Abstract: An etoposide phosphate represented by the formula (1): ##STR1## is prepared by blocking the hydroxyl groups of the saccharide moiety of etoposide with halogenoacetyl groups, thereafter phosphorylating the 4'-position, and removing the halogenoacetyl groups from the obtained phosphate in the presence of an amine.This process can give the objective etoposide phosphate in a higher yield than that of the prior art to enable the industrial mass-production thereof.
    Type: Grant
    Filed: March 27, 1995
    Date of Patent: February 25, 1997
    Assignee: Nippon Kayaku Kabushiki Kaisha
    Inventors: Yoshinobu Miyazawa, Hitoshi Sato, Hiroshi Yoshikawa, Kouichi Ohkawa, Noriko Tomiyoshi