Patents by Inventor Noriko Yokose

Noriko Yokose has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method for determining sensitivity of cyclin-dependent kinase 4/6 inhibitor
    Patent number: 11639940
    Abstract: Disclosed is a method for determining sensitivity to a CDK4/6 inhibitor, comprising the steps of: comparing a value based on activity of at least one CDK selected from CDK4 and CDK6 in a sample collected from a subject, with a threshold level corresponding to the CDK, and determining that the subject is insensitive to the CDK4/6 inhibitor when the value based on the CDK activity is less than the threshold level.
    Type: Grant
    Filed: March 27, 2020
    Date of Patent: May 2, 2023
    Assignee: SYSMEX CORPORATION
    Inventors: Noriko Yokose, Kenta Noda
  • Cyclin-dependent kinase substrate
    Patent number: 10851403
    Abstract: Disclosed is a cyclin-dependent kinase substrate including a polypeptide that contains an amino acid sequence represented by formula (1): R1—P (wherein R1 represents a serine residue or a threonine residue, P represents a proline residue, “—” represents a single bond, and the left side represents the N-terminal side), and satisfies the following (a1) and/or (b1): (a1) the second amino acid residue counting from the proline residue toward the N-terminal side in the formula (1) is an aromatic amino acid residue, and/or (b1) at least two amino acid residues from the proline residue toward the C-terminal side in the formula (1) are acidic amino acid residues.
    Type: Grant
    Filed: May 18, 2018
    Date of Patent: December 1, 2020
    Assignee: SYSMEX CORPORATION
    Inventors: Noriko Yokose, Masatoshi Suganuma, Kenta Noda, Naoki Nishiyama
  • METHOD FOR DETERMINING SENSITIVITY OF CYCLIN-DEPENDENT KINASE 4/6 INHIBITOR
    Publication number: 20200309787
    Abstract: Disclosed is a method for determining sensitivity to a CDK4/6 inhibitor, comprising the steps of: comparing a value based on activity of at least one CDK selected from CDK4 and CDK6 in a sample collected from a subject, with a threshold level corresponding to the CDK, and determining that the subject is insensitive to the CDK4/6 inhibitor when the value based on the CDK activity is less than the threshold level.
    Type: Application
    Filed: March 27, 2020
    Publication date: October 1, 2020
    Applicant: SYSMEX CORPORATION
    Inventors: Noriko YOKOSE, Kenta Noda
  • CYCLIN-DEPENDENT KINASE SUBSTRATE
    Publication number: 20180334702
    Abstract: Disclosed is a cyclin-dependent kinase substrate including a polypeptide that contains an amino acid sequence represented by formula (1): R1-P (wherein R1 represents a serine residue or a threonine residue, P represents a proline residue, “—” represents a single bond, and the left side represents the N-terminal side), and satisfies the following (a1) and/or (b1): (a1) the second amino acid residue counting from the proline residue toward the N-terminal side in the formula (1) is an aromatic amino acid residue, and/or (b1) at least two amino acid residues from the proline residue toward the C-terminal side in the formula (1) are acidic amino acid residues.
    Type: Application
    Filed: May 18, 2018
    Publication date: November 22, 2018
    Applicant: SYSMEX CORPORATION
    Inventors: Noriko Yokose, Masatoshi Suganuma, Kenta Noda, Naoki Nishiyama