Abstract: A bispecific antibody including a first domain which specifically binds to a mutant calreticulin protein and a second domain which specifically binds to a CD3 antigen. A pharmaceutical composition including the bispecific antibody or a functional fragment thereof. A diagnostic method for a myeloproliferative neoplasm, including detecting a polypeptide in a biological sample with the bispecific antibody.

Abstract: A seal device that includes a seal portion protruding from a resilient body member in a common direction with a seal lip member. The seal portion being shorter in length and having a thickness that is thinner than the lip seal member. A gap is defined between an action diameter surface of the seal lip member and one of either a retainer portion or a ring member, wherein the seal portion contacts the other one of the retainer portion or ring member. A pressure receiving groove is defined between the seal lip member and the seal portion, and is in communication with the gap.

Abstract: The seal device is for providing seal capability of the seal faces of the seal rings from being damaged due to elastic deformation of the seal contact surfaces of the resilient body members acted on by fluid pressure. It is also for preventing wear of the seal contact surfaces of the resilient body members.

Abstract: Provided is an ink jet recording paper having an ink receiving layer comprising a high absorption pigment and a binder provided on at least one side of a base paper comprising wood pulp and a filler, with the ink receiving layer having a coverage rate of from 0.5 to 5.0 g/m.sup.2 per side of the base paper and a contact angle of from 80 to 100 degrees measured using a liquid having a surface tension of 40 dyne/cm.

Abstract: Provided are a both-sided recording paper for ink jet recording which has coated layers comprising a pigment and a water-base binder on both sides of a base paper made from pulp slurry comprising a filler and an internal sizing agent; with the coated layers having a per side coverage of from 0.5 to 4.0 g/m.sup.2, on a solids basis, and with the base paper having a basis weight of from 50 to 180 g/m.sup.2, a total filler content within the range of 3 to 20 weight %, and a difference in filler content between surface layers extending to 30 .mu.m below the front and rear surfaces of the base paper respectively within the range of 0 to 30% of the average value of filler contents in the surface layers: and a method of preparing the aforementioned both-sided recording paper.

Abstract: A recording paper having a recording layer comprising synthetic silica and an aqueous binder as its principal components, said layer being formed on at least one surface of a base paper and the amount of said layer lying within the range of 0.5-4.0 g/m.sup.2 in terms of solids on each surface on which said layer is formed, wherein either the critical surface tension of said recording layer surface (.gamma..sub.c) lies within the limits 32.ltoreq..gamma..sub.c.ltoreq. 42 dyne/cm or the contact angle measured using water lies in the range of 100.degree.-120.degree., or alternatively, the critical surface tension of said recording layer surface (.gamma..sub.c) lies within the limits 32.ltoreq..gamma..sub.c.ltoreq. 42 dyne/cm and the contact angle measured using water lies in the range of 100.degree.-120.degree. is disclosed.

Abstract: A method for operating a shaft furnace is performed by charging different ore/coke ratio mixture in radially different positions in the furnace. The ore/coke mixture ratio may be determined according to desired heat distribution in radial direction. For this, at least two mutually independently determined ore/coke mixture ratio mixtures are provided in each charge cycle of the burden. The mixture to be charged in the central portion of the furnace may have a higher coke content or a lower ore content for better permeability to the heating gas.