Abstract: Provided is a modifier for an ophthalmic device capable of imparting high wettability and lubricity to a silicone hydrogel, specifically, a modifier for an ophthalmic device capable of expressing such effect when contained in a small amount. Also provided are a silicone hydrogel obtained by curing a silicone hydrogel composition containing the modifier for an ophthalmic device, and an ophthalmic device using the silicone hydrogel. It has been found that a water-soluble silicone-containing water-soluble copolymer obtained by copolymerizing a phosphorylcholine group-containing monomer and a specific silicone monomer can impart high wettability and lubricity to a silicone hydrogel when contained in a small amount.

Abstract: A monomer composition including (A) a phosphorylcholine group-containing polysiloxane monomer represented by the following formula (1), (B) a siloxanyl group-containing silicone monomer having at least one or more hydroxy groups in a molecule, represented by the following formula (2) or (3), (C) one or more hydrophilic monomers selected from hydroxyethyl (meth)acrylate, hydroxypropyl (meth)acrylate, and hydroxybutyl (meth)acrylate, (D) methacrylic acid, and (E) a hydrophilic monomer other than the component (C), a represents an integer of 20 to 500, b represents an integer of 1 to 70, c represents an integer of 1 to 70, d represents 0 or 1, p and q each represent 0 or 1, X represents —CH2— or —CH2CH2—, and R represents an alkyl group having 2 to 18 carbon atoms,

Abstract: Provided is a surface treatment agent for an ophthalmic device that can impart wettability and lubricity to the surface of a silicone hydrogel, more specifically, a surface treatment agent for an ophthalmic device that can subject the silicone hydrogel to surface treatment even when the silicone hydrogel is not caused to present any specific complementary functional group. Also provided are a surface-treated silicone hydrogel whose surface has been treated with the surface treatment agent for an ophthalmic device, and an ophthalmic device using the surface-treated silicone hydrogel. It has been found that the above-mentioned objects can be achieved by using a water-soluble copolymer obtained by copolymerizing a phosphorylcholine group-containing monomer, a specific silicone monomer, and a thermally reactive monomer or a photoreactive monomer, the copolymer having water solubility controlled to a specific level. Thus, the present invention has been completed.

Abstract: Provided is a contact lens that can exhibit excellent breaking elongation and surface hydrophilicity even when produced using a hydrophobic mold made of polypropylene or the like without performing a surface hydrophilic treatment. Further provided are a monomer composition and a polymer that can be suitably used for obtaining the contact lens. This monomer composition contains (A) a siloxanyl group-containing itaconic acid diester monomer, (B) an amide group-containing monomer, (C) a hydroxy group-containing monomer, (D) a siloxanyl group-containing (meth)acrylate, and (E) a cross-linking agent in a specific ratio.

Abstract: Provided is a monomer suitable for application to an ophthalmic device, the monomer showing high surface hydrophilicity, a high oxygen transmissibility, and appropriate mechanical strength when copolymerized with a polymerizable monomer, such as a hydrophilic monomer. It has been recognized that a phosphorylcholine group-containing polysiloxane monomer can solve the problems.

Abstract: Provided is a treating solution for soft contact lenses capable of imparting hydrophilicity and sustainability thereof to a soft contact lens surface. It has been found that a treating solution for soft contact lenses containing a copolymer that contains two kinds of monomers different from each other as constituent units at a specific ratio, and that has a specific weight-average molecular weight can impart excellent hydrophilicity and sustainability thereof.

Abstract: The phosphorylcholine group-containing polysiloxane monomer of the present invention is represented by the formula (1). In the formula, a represents an integer of 20 to 500, b represents an integer of 1 to 70, c represents an integer of 1 to 70, d represents 0 or 1, p and q each represent 0 or 1, X represents —CH2— or —CH2CH2—, and R represents an alkyl group having 2 to 18 carbon atoms. The present invention provides the phosphorylcholine group-containing polysiloxane monomer which gives, when copolymerized with a polymerizable monomer such as methacrylic acid or a hydrophilic monomer other than methacrylic acid, a polymer that exhibits surface hydrophilicity and sufficient stability as ophthalmic devices.

Abstract: Provided is a monomer composition for contact lenses, which uses a polysiloxane monomer to produce a polymer that shows satisfactory surface hydrophilicity and oxygen permeability, and that is excellent in modulus and elongation at break. It has been found that a monomer composition containing a phosphorylcholine group-containing polysiloxane monomer, a monovinyl ether monomer, and the like can achieve the above-mentioned object.

Abstract: The invention is a phosphorylcholine group-containing vinyl monomer represented by the following formula (1): in the formula (1) R represents an alkylene group having 1 to 6 carbon atoms, and n represents an integer of 1 to 6. The invention provides a phosphorylcholine group-containing vinyl monomer useful as a raw material for a hydrogel having a lowered water content while maintaining surface hydrophilicity.

Abstract: Provided is a contact lens that can exhibit excellent breaking elongation and surface hydrophilicity even when produced using a hydrophobic mold made of polypropylene or the like without performing a surface hydrophilic treatment. Further provided are a monomer composition and a polymer that can be suitably used for obtaining the contact lens. This monomer composition contains (A) a siloxanyl group-containing itaconic acid diester monomer, (B) an amide group-containing monomer, (C) a hydroxy group-containing monomer, (D) a siloxanyl group-containing (meth)acrylate, and (E) a cross-linking agent in a specific ratio.

Abstract: Provided is a monomer suitable for application to an ophthalmic device, the monomer showing high surface hydrophilicity, a high oxygen transmissibility, and appropriate mechanical strength when copolymerized with a polymerizable monomer, such as a hydrophilic monomer. It has been recognized that a phosphorylcholine group-containing polysiloxane monomer can solve the problems.

Abstract: Provided is a treating solution for soft contact lenses capable of imparting hydrophilicity and sustainability thereof to a soft contact lens surface. It has been found that a treating solution for soft contact lenses containing a copolymer that contains two kinds of monomers different from each other as constituent units at a specific ratio, and that has a specific weight-average molecular weight can impart excellent hydrophilicity and sustainability thereof.

Abstract: [Object] To provide a phosphorylcholine group-containing compound capable of producing a phosphorylcholine complex, and the phosphorylcholine complex, the phosphorylcholine complex being easily manufactured and suitable for use as a phosphorylcholine antigen. [Solving Means] There are provided a phosphorylcholine group-containing compound having a structure represented by the following formula (1), and a phosphorylcholine-protein complex having a structure in which the phosphorylcholine group-containing compound and an amino acid amine site of a protein are amide bonded. (X represents a hydrogen atom, a monovalent cation residue, or a hydroxysuccinimide group).

Abstract: [Object] To provide a phosphorylcholine group-containing compound capable of producing a phosphorylcholine complex, and the phosphorylcholine complex, the phosphorylcholine complex being easily manufactured and suitable for use as a phosphorylcholine antigen. [Solving Means] There are provided a phosphorylcholine group-containing compound having a structure represented by the following formula (1), and a phosphorylcholine-protein complex having a structure in which the phosphorylcholine group-containing compound and an amino acid amine site of a protein are amide bonded.

Abstract: Provided are a contact lens care preparation capable of imparting durable surface lubricity and amebic adhesion inhibitory effect to a contact lens surface through a simple treatment, and a contact lens packaging solution utilizing the same. The contact lens care preparation is composed of a solution containing 0.01 to 2 weight/volume % of a polymer having particular monomer units with a phosphorylcholine-like group, particular (meth)acrylamide derivative units, and particular monomer units with a hydrophobic group at a particular ratio, and a weight average molecular weight of 5,000 to 2,000,000, and is useful as a contact lens packaging solution.

Abstract: Provided are a polymer having low cytotoxicity and capable of imparting surface hydrophilicity and biocompatibility to medical device surfaces by simple processing, a method for producing the polymer, and a surface treatment agent for medical devices. The polymer of the present invention has a particular ratio of structural units represented by the formulae (1a) and (1b), and a particular weight average molecular weight, and is useful as a surface treatment agent for various medical devices.

Abstract: Provided are a contact lens care preparation capable of imparting durable surface lubricity and amebic adhesion inhibitory effect to a contact lens surface through a simple treatment, and a contact lens packaging solution utilizing the same. The contact lens care preparation is composed of a solution containing 0.01 to 2 weight/volume % of a polymer having particular monomer units with a phosphorylcholine-like group, particular (meth)acrylamide derivative units, and particular monomer units with a hydrophobic group at a particular ratio, and a weight average molecular weight of 5,000 to 2,000,000, and is useful as a contact lens packaging solution.

Abstract: Provided are a polymer having low cytotoxicity and capable of imparting surface hydrophilicity and biocompatibility to medical device surfaces by simple processing, a method for producing the polymer, and a surface treatment agent for medical devices. The polymer of the present invention has a particular ratio of structural units represented by the formulae (1a) and (1b), and a particular weight average molecular weight, and is useful as a surface treatment agent for various medical devices.

Abstract: Provided are amino group-containing phosphorylcholine compound and a method for production thereof, that has a highly active amino group efficiently reactive with a wide variety of functional groups and the like under mild conditions, and is capable of introducing a phosphorylcholine-like group to various substrate surfaces to provide functionalities of the group. The amino group-containing phosphorylcholine compound of the present invention is represented by at least one of formulae (1) and (1?), and may be used as a compound, or a material thereof, capable of introducing a phosphorylcholine-like group to the surface of various substrates, such as medical instruments, cosmetics materials, and medicinal substances.

Abstract: Provided are amino group-containing phosphorylcholine compound and a method for production thereof, that has a highly active amino group efficiently reactive with a wide variety of functional groups and the like under mild conditions, and is capable of introducing a phosphorylcholine-like group to various substrate surfaces to provide functionalities of the group. The amino group-containing phosphorylcholine compound of the present invention is represented by at least one of formulae (1) and (1?), and may be used as a compound, or a material thereof, capable of introducing a phosphorylcholine-like group to the surface of various substrates, such as medical instruments, cosmetics materials, and medicinal substances.