Abstract: A bispecific antibody including a first domain which specifically binds to a mutant calreticulin protein and a second domain which specifically binds to a CD3 antigen. A pharmaceutical composition including the bispecific antibody or a functional fragment thereof. A diagnostic method for a myeloproliferative neoplasm, including detecting a polypeptide in a biological sample with the bispecific antibody.

Abstract: It is an object of the present invention to provide a therapeutic drug for polycythemia. According to the present invention, provided is a therapeutic drug for polycythemia, comprising an antibody which recognizes the amino acids at positions 629 to 633 of a human transferrin receptor.

Abstract: Cytotoxic T cells derived from human T cell-derived iPS cells may avoid an NK cell missing-self response and may be used for allogeneic administration while maintaining a strong antitumor effect of antigen-specific CTLs. A method may produce a cytotoxic T cell derived from a human T cell-derived iPS cell expressing HLA class I of HLA-restricted class I of an antigen epitope of a CTL and HLA-E. Such a method may include: knocking out all HLA class I of the human T cell-derived iPS cell; introducing a gene of the HLA-restricted HLA class I of the antigen epitope of the CTL and a gene of the HLA-E into the T-iPS cell in which all HLA class I have been knocked out; and redifferentiating the genetically introduced T-iPS cell into a CD8 single-positive T cell.

Abstract: Provided is an immune cell therapy which uses an iPS technology allowing long-term survival in a living body and which exhibits an excellent antitumor effect by recognition of two antigens. An iPS cell derived from an antigen-specific cytotoxic T cell having a chimeric antigen receptor introduced therein.

Abstract: A diagnostic, preventive, or therapeutic agent may be used for a myeloproliferative neoplasm. An antibody or a functional fragment thereof that binds to a cleaved mutant CALR protein, may include an antigen-recognition site in (a) a polypeptide chain having an amino acid sequence set forth in SEQ ID NO: 1 or (b) a polypeptide chain having an amino acid sequence having deletion, substitution, or addition of one to several amino acids in SEQ ID NO: 1; and a diagnostic, preventive, or therapeutic agent for a myeloproliferative neoplasm containing the antibody.

Abstract: Provided are techniques by which a mutant gene in a gene group comprising a large number of wild-type genes can be detected with high sensitivity and in a rapid and simple way. Provided is a method for measuring a nucleic acid for the purpose of specifically detecting a genotype as an examination target from subjects which are genes or specimens likely to have a plurality of genetic polymorphisms, wherein the measurement method comprises hybridizing a fluorescent dye-labeled oligonucleotide with a genotype other than the examination target to suppress the gene amplification of such genotype while at the same time, hybridizing the same fluorescence-labeled oligo as described above with an amplification product derived from the genotype of the examination target amplified in the same gene amplification step as described above, and specifically detecting the genotype of the examination target based on a change in the fluorescence intensity of the fluorescent dye before and after the hybridization.

Abstract: In a filter element, at both ends of a cylindrical main filter medium having a space formed on its inner periphery side there are respectively formed a first cap having a communication port for communication of the space with the exterior and a second cap for closing the space, and a pre-filter medium is inserted removably into the space from the communication port. A case comprises a body case for accommodating the filter element removably from an opening thereof in a state in which a gap is formed between the body case and the outer periphery of the main filter medium, and a lid for closing the opening. With the lid attached to the body case, a gas inflow space (flow path) with the communication port positioned therein and a gas outflow space (flow path) with the gap positioned therein are partitioned from each other by a partitioning portion (upper fitting portion).