Abstract: In order to cut a plurality of clumps having an approximately uniform shapes and approximately uniform dimensions out of a cell aggregate which has proliferated and appropriately eliminate contamination with fragments of different shapes or dimensions, when cutting the clumps of approximately uniform shape out of the cell aggregate which has proliferated, cutting lines along which the clumps of a specific shape are cut out are set such that the area of a peripheral part of the cell aggregate which is not cut by the cutting line exceeds the surface area of one of the clumps, and the cell aggregate is cut by irradiating with laser light in such a way as to trace the cutting lines.

Abstract: A laser processing machine for killing specific cells from a group of cells on a surface of a layer containing an ingredient capable of absorbing laser light, the laser processing machine being configured to: control a laser light source to output laser light at 5 W or less and at a wavelength of 380 nm or greater such that the laser light source is applied to a second area on a second surface of the layer opposed to the first surface; and control an actuator to provide a relative movement between the second area where the laser light is applied and the layer at a rate of 2000 mm/sec or less such that the irradiated second area absorbs energy to generate heat that kills unwanted cells on a first area of the first surface and the laser light does not instantly kill the specific cells on the first area upon irradiation.

Abstract: A cell culture vessel for use with a laser processing machine, including: a layer containing an ingredient that generates heat upon laser irradiation; the layer kills specific cells from among a group of cells cultured on a first surface of the layer when a second surface of the layer is irradiated with laser light having an output of 5W or less at a wavelength of 380 nm or greater and a relative movement between a second area on the second surface where the laser light is applied and the layer is at a rate of 2000 mm/sec or less such that the second area absorbs energy of the laser light to generate heat that kills the specific cells that are present on a first area of the first surface and the laser light does not instantly kill the specific cells on the first area upon irradiation with the laser light.

Abstract: A method of killing specific cells from among a group of cells cultured in a culture vessel by quick and brief laser treatment, the cell culture vessel comprising a main body and a to-be-irradiated layer attached to the main body, the to-be-irradiated layer containing an ingredient capable of absorbing laser light upon laser irradiation, the group of cells being cultured on the surface of the to-be-irradiated layer, the method comprising: applying laser light to a partial area of the to-be-irradiated layer directly below the specific cells.

Abstract: In order to cut a plurality of clumps having an approximately uniform shapes and approximately uniform dimensions out of a cell aggregate which has proliferated and appropriately eliminate contamination with fragments of different shapes or dimensions, when cutting the clumps of approximately uniform shape out of the cell aggregate which has proliferated, cutting lines along which the clumps of a specific shape are cut out are set such that the area of a peripheral part of the cell aggregate which is not cut by the cutting line exceeds the surface area of one of the clumps, and the cell aggregate is cut by irradiating with laser light in such a way as to trace the cutting lines.

Abstract: A method of killing specific cells from among a group of cells cultured in a culture vessel by quick and brief laser treatment, the cell culture vessel comprising a main body and a to-be-irradiated layer attached to the main body, the to-be-irradiated layer containing an ingredient capable of absorbing laser light upon laser irradiation, the group of cells being cultured on the surface of the to-be-irradiated layer, the method comprising: applying laser light to a partial area of the to-be-irradiated layer directly below the specific cells.

Abstract: A processing machine includes mirrors and to reflect a beam L oscillated from a laser oscillator to a predetermined surface on which a workpiece is arranged, optical axis operating mechanisms and to position an optical axis of the beam L at a desired target irradiation position by changing directions of the mirrors and, a camera sensor to capture an image of the target irradiation position and its periphery reflected in the mirror, and an error calibration mechanism to detect an error between the target irradiation position instructed to the optical axis operating mechanisms and an actual position of the optical axis of the beam L in the predetermined surface by referring to the image captured by the camera sensor. A correction amount to the optical axis operating mechanisms and is determined based on the error to irradiate the target irradiation position with the beam L during processing.

Abstract: A DNA hybrid which comprises a porous oxide matrix and DNA immobilized thereon, and is useful for environmental clean-up, where the hybrid is prepared by removing a dispersion medium from a dispersion of colloidal oxide and DNA.

Abstract: A processing machine includes mirrors and to reflect a beam L oscillated from a laser oscillator to a predetermined surface on which a workpiece is arranged, optical axis operating mechanisms and to position an optical axis of the beam L at a desired target irradiation position by changing directions of the mirrors and, a camera sensor to capture an image of the target irradiation position and its periphery reflected in the mirror, and an error calibration mechanism to detect an error between the target irradiation position instructed to the optical axis operating mechanisms and an actual position of the optical axis of the beam L in the predetermined surface by referring to the image captured by the camera sensor. A correction amount to the optical axis operating mechanisms and is determined based on the error to irradiate the target irradiation position with the beam L during processing.

Abstract: [PROBLEMS] To provide a cigarette filter that does not impair the distinctive flavor of a cigarette and the air permeability of filter while smoking, and at the same time, can more effectively remove harmful substances such as a pyrene that is generated from the cigarette. [MEANS FOR SOLVING PROBLEMS] The cigarette filter comprising a filter fiber bundle body which cigarette smoke passes through; a fine powder with a high surface area ratio that are mixed and scattered in the filter fiber bundle body; and a double-stranded DNA molecule attached to the outer surface of the fine powder with a high surface area ratio, characterized in that harmful substances such as benzo[a]pyrene contained in the cigarette smoke can be removed by intercalation into the double-stranded DNA molecule.

Abstract: A method and a filter for efficiently removing harmful substances in ambient air or generated from tobacco, such as dioxins and pyrene, using DNA are provided. Specifically, in the method, gas containing harmful substances is brought into contact with DNA to be trapped by the DNA, thereby being removed. The filter for removing harmful substances includes DNA and a supporter for supporting the DNA.

Abstract: Provided are a DNA carrier where DNA is firmly held in a substrate, which can reduce the elution of DNA into water and can take full advantage of the capability of DNA to selectively and specifically collect a substance; and a method of producing the DNA carrier. Also provided is a collection system using DNA, which can be used in the high-accuracy detection of a particular substance and in an environmental cleanup capable of efficiently removing a substance, in which the DNA carrier is used to collect the substance contained in air or water by taking full advantage of the capability of DNA to selectively and specifically collect the substance. The DNA carrier is one where DNA is held in a porous matrix containing polyorganosiloxane with a basic functional group and particles. Preferably, the polyorganosiloxane with a basic functional group contains a hydrolysis condensate of one or more of particular silane compounds with an amino group.

Abstract: A DNA hybrid which comprises a porous oxide matrix and DNA immobilized thereon, and is useful for environmental clean-up, where the hybrid is prepared by removing a dispersion medium from a dispersion of colloidal oxide and DNA.

Abstract: There is provided a method of removing harmful substance characterized by comprising contacting a harmful substance-containing liquid to be treated with a double-stranded DNA, adsorbing the harmful substance onto the double-stranded DNA through intercalation, and separating it. The method is particularly useful for removing dioxins, and can be carried out by contacting a liquid to be treated with an adsorbent comprising a double-stranded DNA or a solution containing a double-stranded DNA enclosed in a container or a bag made of a membrane that is permeable for the harmful substance but is not permeable for the double-stranded DNA.

Abstract: A DNA hybrid which comprises a porous oxide matrix and DNA immobilized thereon, and is useful for environmental clean-up, where the hybrid is prepared by removing a dispersion medium from a dispersion of colloidal oxide and DNA.

Abstract: A liquid containing a separation target substance is brought into contact with a double helix DNA-holding phase to have the separation target substance held by the double helix DNA-holding phase, which is then removed from the liquid. On this occasion, the contact of the double helix DNA with the separation target substance is performed in an aqueous medium having a salt concentration of 0.02 mass % or more.

Abstract: A method and a filter for efficiently removing harmful substances in ambient air or generated from tobacco, such as dioxins and pyrene, using DNA are provided.

Abstract: A polypeptide comprising repeated amino acid sequences of a cell-adhesive protein represented by the formula:(Arg-Gly-Asp)n or (Tyr-Ile-Gly-Ser-Arg)nwherein n is a number ranging from 2 to 20; or a pharmaceutical acceptable salt thereof, which is valuable as an antimetastatic agent for cancer.

Abstract: A polypeptide comprising repeated amino acid sequences of a cell-adhesive protein represented by the formula:(Arg--Gly--Asp)nor(Tyr--Ile--Gly--Ser--Arg)nwherein n is a number ranging from 2 to 20; or a pharmaceutical acceptable salt thereof, which is valuable as an antimetastatic agent for cancer.

Abstract: The invention provides a novel method for making paper of regenerated chious fibers without the use of any binder materials. By virtue of the inherent physiological inertness of the chitinous fibers and the absence of any binder materials, the paper obtained by the inventive method is advantageously used in medical treatment in contact with living body tissues. The principle of the method is that the chitinous fibers prepared by a wet spinning process are never brought into a dry condition or always kept wet with water down to the step of sheet making so that the self-bonding power of the fibers by the hydrogen bonding is never decreased and a chitinous paper with sufficient strengths can be prepared without a binder material. Alternatively, once dried chitinous fibers can be treated with a hydrogen-bond forming agent, e.g. urea, so that the sheet making is equally successful without the use of a binder material.