Abstract: The present invention searches for compounds etc. that may inhibit the interaction between the spike (S) protein of SARS-CoV-2 and the ACE2 protein. The present invention provides a composition for inhibiting the binding between the spike (S) protein of SARS-CoV-2 and the angiotensin converting enzyme 2 (ACE2) protein comprising an effective amount of chlorine dioxide.

Abstract: The object of the present invention is to search for and to provide a novel acetylcholinesterase inhibitor. An acetylcholinesterase inhibitor comprising wood creosote as the active ingredient is provided.

Abstract: A measure that can readily prevent arthropod-borne diseases such as malaria that are contracted by 3 to 5 hundred million people worldwide yearly and that cause death of as many as 1.5 to 2.7 million people. By spraying in advance on the skin an arthropod-borne disease preventive agent or the like including chlorine dioxide as an effective component thereof, it is possible to provide repelling effect against arthropods such as infected mosquitoes that bear malaria protozoa and also to prevent biting of the skin by the arthropod, thus reducing contraction of the arthropod-borne diseases.

Abstract: A method of controlling floating virus infection. The method includes the step of: supplying chlorine dioxide gas into a space where floating virus can be present by a gas concentration which allows the animal to live or stay, but deactivates the virus.

Abstract: There are provided a chlorine dioxide solution composition whose solute includes dissolved chlorine dioxide and chlorite; and a solution composition encapsulating body including a glass vessel or enameled vessel and the chlorine dioxide solution composition hermetically sealed therein.

Abstract: The invention provides a measure that can readily prevent arthropod-borne diseases such as malaria that are contracted by 3 to 5 hundred million people worldwide yearly and that cause death of as many as 1.5 to 2.7 million people. By spraying in advance on the skin an arthropod-borne disease preventive agent or the like comprising chlorine dioxide as an effective component thereof, it is possible to provide repelling effect against arthropods such as infected mosquitoes that bear malaria protozoa and also to prevent biting of the skin by the arthropod, thus reducing contraction of the arthropod-borne diseases.

Abstract: There are provided a chlorine dioxide solution composition whose solute includes dissolved chlorine dioxide and chlorite; and a solution composition encapsulating body including a glass vessel or enameled vessel and the chlorine dioxide solution composition hermetically sealed therein.

Abstract: A method of controlling floating virus infection. The method includes the step of: supplying chlorine dioxide gas into a space where floating virus can be present by a gas concentration which allows the animal to live or stay, but deactivates the virus.

Abstract: A self-heat exchange type heat exchanger which can provide a greater heat transfer area in a limited capacity, can be easily prepared and can lead to drastic enhancement of heat exchange efficiency.

Abstract: In a process for producing bisphenol A, an adduct of bisphenol A with phenol is promptly recovered in highly purity and high efficiency from a reaction mother liquor in the case of singling out bisphenol A from a reaction product. An adduct layer of bisphenol A with phenol is formed by crystallizing an adduct of bisphenol A with phenol from a solution of bisphenol A in phenol to form a slurry, the bisphenol A being produced by reacting phenol and acetone in the presence of an acid catalyst, subjecting the resultant slurry to a solid-liquid separation treatment, and thereafter removing the phenol from solid components, characterized by pouring onto a filter, a slurry solution of bisphenol A in phenol, the slurry solution containing in a crystalline state, an adduct of bisphenol A having an average particle size in the range of 0.05 to 1 mm with phenol, and filtering the slurry solution under reduced pressure in an atmosphere of an inert gas stream at 30 to 80° C.

Abstract: In a process for producing bisphenol A, an adduct of bisphenol A with phenol is promptly recovered in highly purity and high efficiency from a reaction mother liquor in the case of singling out bisphenol A from a reaction product. An adduct layer of bisphenol A with phenol is formed by crystallizing an adduct of bisphenol A with phenol from a solution of bisphenol A in phenol to form a slurry, the bisphenol A being produced by reacting phenol and acetone in the presence of an acid catalyst, subjecting the resultant slurry to a solid-liquid separation treatment, and thereafter removing the phenol from solid components, characterized by pouring onto a filter, a slurry solution of bisphenol A in phenol, the slurry solution containing in a crystalline state, an adduct of bisphenol A having an average particle size in the range of 0.05 to 1 mm with phenol, and filtering the slurry solution under reduced pressure in an atmosphere of an inert gas stream at 30 to 80° C.

Abstract: In the process for producing bisphenol A comprising crystallizing an adduct of bisphenol A and phenol from a phenol solution of bisphenol A obtained by reacting phenol and acetone in the presence of an acid catalyst, treating the formed slurry by solid-liquid separation and removing phenol from the solid component, a layer of the crystalline adduct is formed on a filter by filtering slurry (1) comprising the crystalline adduct, washing the layer of the adduct with a washing liquid, dissolving the layer of the adduct in a solution comprising phenol, producing slurry (2) comprising the crystalline adduct by crystallization, and separating the crystalline adduct by centrifugation of slurry (2). When bisphenol A is separated from the reaction mixture, the adduct of bisphenol A and phenol can be recovered from the mother liquor of the reaction efficiently at a high purity in accordance with the above process.

Abstract: There is provided a basic association unit for creating an information processing apparatus capable of performing information processing like information processing that actually occurs in central nerve systems of animals including human beings. The association unit is an unit for repeating input and output signals having m input terminals and n output terminals. When a first input signal which is a rectangular wave signal in the form of a pulse is simultaneously input to input terminals in a quantity less than m, an output signal having the same contents as the first input signal is output from particular output terminals which are associated with the input terminals in advance.

Abstract: An intestinal juice level regulator comprising, as the active ingredient, creosote or phenolic derivatives constituting creosote. As having the activities to promote the absorption of intestinal juices and/or to retard the secretion of intestinal juices, the active ingredient lowers the intestinal juice level in intestines. As the phenolic derivatives, usable are one or more of guaiacol, creosol, phenol, cresol and xylenol. The regulator is especially effective for retarding the hypersecretion of intestinal juices to be caused by heat-labile or heat-stable enterotoxin of enterotoxigenic Escherichia coli.

Abstract: The invention relates to a method of synthesizing polydeoxyribonucleotides which comprises causing a thermostable deoxyribunucleotide polymerase to act on deoxyribonucleotides without using any template and any primers, to the thus-obtained polydeoxyribonucleotides, to a method of screening cDNA libraries using the same as probes, to a method comprising joining the DNA resulting from the above method of synthesis to the 3'--OH terminus of a double-stranded DNA containing a gene derived from cells of a living organism, followed by transfection of such cells with the product of joining and culture of the cells, to thereby cause insertion of the product into chromosomal DNA and production of the protein encoded by the gene, to a method of synthesizing chromosomal DNA and to a method of synthesizing chromosomes.

Abstract: A process for efficiently manufacturing high purity polyarylene sulfide. The process comprises feeding a liquid or gaseous sulfur compound (e.g. hydrogen sulfide) to a mixture comprising lithium hydroxide and a non-lithium hydroxide solid compound (e.g. alkali metal chloride or alkaline earth metal chloride) in a non-protonic organic solvent (e.g. N-methyl-2-pyrrolidone), separating the alkali metal chloride or alkaline earth metal chloride, adjusting the sulfur content of the reaction mixture, feeding a dihalogeno aromatic compound e.g. p-dichlorobenzene) to effect a polycondensation reaction, and adding of an alkali metal hydroxide (e.g. sodium hydroxide) to recover lithium ion.

Abstract: A polyarylene sulfide has an inherent viscosity [.eta..sub.i n h ] of 0.1 to 0.5 dl/g, a weight-average molecular weight of 1.times.10.sup.4 to 2.times.10.sup.5 ; a ratio of the inherent viscosity [.eta..sub.i n h ] to a calculated viscosity [.eta.].sub.calc ([.eta..sub.i n h /[.eta.].sub.calc) of 0.4/1 to 0.8/1; and a degree of whiteness of 50 or higher when measured in accordance with whiteness testing procedures (JIS P8123). The polyarylene sulfide is prepared by reaction by contacting at least one member of a metallic sulfide (A) selected from an alkali metal sulfide and an alkali metal hydrosulfide with a dihalogen aromatic compound (B) and an aromatic compound (C) having three or more than three functional groups in a polar solvent in a molar ratio of the dihalogen aromatic compound (B) to the metallic sulfide (A) [(B)/(A)] ranging from 1.035/1 to 1.300/1 and in a molar ratio of the aromatic compound (C) to the dihalogen aromatic compound (B) [(C)/(B)] ranging from 0.003/1 to 0.05/1.

Abstract: Disclosed are an antispasmodic agent comprising creosote or its component phenol derivative as an active ingredient, and the use of creosote or its component phenol derivative for treating spasms in a patient.

Abstract: Polyarylene sulfides are produced by polymerizing a dihalogen aromatic compound with an alkali metal hydrosulfide in the presence of a lithium halide in an organic polar solvent. In this polymerization, an alkali metal hydroxide and/or carbonate is added and a branching agent such as a trihalogen aromatic compound or a halogen aromatic nitro compound is used, if desired.The polyarylene sulfides have a high molecular weight and a less salt contents and a high degree of whiteness.

Abstract: The present invention provides a method of recovering a lithium chloride, which comprises reacting a dihalogenated aromatic compound and an alkali metal sulfide and/or alkali metal hydrogen sulfide in a polar solvent under the pressure of lithium chloride, separating a solvent insoluble component from the resultant reaction mixture to obtain a solution, and calcinating a residue obtained by removing volatile substances from the resultant solution, as well as a method of recovering a lithium chloride, which comprises reacting a dihalogenated aromatic compound and an alkali metal sulfide and/or alkali metal hydrogen sulfide in a polar solvent under the pressure of lithium chloride, separating the granular polymer ingredient from the resultant reaction mixture subjecting the liquid suspension obtained by said separation to solid-liquid separation and calcinating the residue obtained by removing volatile substances from the resultant solution component.