Abstract: A bispecific antibody including a first domain which specifically binds to a mutant calreticulin protein and a second domain which specifically binds to a CD3 antigen. A pharmaceutical composition including the bispecific antibody or a functional fragment thereof. A diagnostic method for a myeloproliferative neoplasm, including detecting a polypeptide in a biological sample with the bispecific antibody.

Abstract: An easily openable metal can largely openable in the arranged state of two sheet metal-made cans in series. A means such as a projection for opening the drinking mouth of another can is formed at the lower part of a can body, and a break line and a means for guiding the means such as the projection are formed at the upper part thereof.

Abstract: Provided is a syringe needle guiding apparatus 4 which creates images of a blood vessel 9 which cannot be directly seen with the naked eyes and of a syringe needle 10 inserted into a body, and which includes a monitor 3 allowing the recognition of the three-dimensional relationship between the blood vessel 9 and the needle 10. In the syringe needle guiding apparatus 4 provided here, the blood vessel 9 is seen through by using near infrared rays and also a part of the needle 10, which cannot be seen through because it is inserted into a body, is reproduced in a form of virtual image. A virtually synthesized image of the blood vessel 9 and the needle 10 is displayed on the monitor 3. Then, a target 88 at which the needle 10 is to be inserted, a direction, a distance 12-A, an angle 12-B of the needle with respect to the blood vessel, and the like are displayed in the synthesized image, so that the positional relationship between the blood vessel and the needle 10 is recognized in a three-dimensional manner.

Abstract: Provided is a syringe needle guiding apparatus 4 which creates images of a blood vessel 9 which cannot be directly seen with the naked eyes and of a syringe needle 10 inserted into a body, and which includes a monitor 3 allowing the recognition of the three-dimensional relationship between the blood vessel 9 and the needle 10. In the syringe needle guiding apparatus 4 provided here, the blood vessel 9 is seen through by using near infrared rays and also a part of the needle 10, which cannot be seen through because it is inserted into a body, is reproduced in a form of virtual image. A virtually synthesized image of the blood vessel 9 and the needle 10 is displayed on the monitor 3. Then, a target 88 at which the needle 10 is to be inserted, a direction, a distance 12-A, an angle 12-B of the needle with respect to the blood vessel, and the like are displayed in the synthesized image, so that the positional relationship between the blood vessel and the needle 10 is recognized in a three-dimensional manner.

Abstract: An easily openable metal can largely openable in the arranged state of two sheet metal-made cans in series. A means such as a projection for opening the drinking mouth of another can is formed at the lower part of a can body, and a break line and a means for guiding the means such as the projection are formed at the upper part thereof.