Abstract: To provide a method and kit for measurement of a target substance with high detection sensitivity, provided is a method of measuring at least any one of the presence or absence, and a concentration, of a target substance in a sample liquid, the method including the steps of: (a) preparing a first particle that specifically binds to the target substance and contains a rare earth complex, and a second particle that has a larger average particle diameter than that of the first particle and specifically binds to the target substance; (b) mixing the sample liquid, the first particle, and the second particle to provide a mixed liquid; and (c) determining at least any one of the presence or absence, and the concentration, of the target substance from polarization anisotropy of the mixed liquid obtained in the step (b).

Abstract: Provided is a particle having high detection sensitivity in the detection of a substance to be measured, such as an antigen or an antibody, from a body. The particle includes a rare earth complex, wherein the particle has a particle size distribution of 0.1 or less in terms of polydispersity index (pdi) measured by dynamic light scattering, and wherein the particle has a hydrophilic polymer on a surface thereof.

Abstract: A measuring method includes a first sequence for acquiring a first result about the anisotropy by performing a dispensing step and a measuring step and for measuring concentration of the measurement object from the first result based on a relationship between the anisotropy and a dispensing amount of the fluorescent reagent dispensed in the dispensing step, and a second sequence for acquiring a second result about the anisotropy by performing the dispensing step and the measuring step one or more times after the first sequence and for measuring the concentration of the measurement object from the second result based on the relationship between the anisotropy measured in the measuring step and the dispensing amount of the fluorescent reagent dispensed in the dispensing step.

Abstract: An optical measurement method comprises a holding step, a measurement step, and a first application step. In the holding step, a specimen solution containing a specimen and the magnetic particles is held in a specific magnetic field state, in which a magnetic field not lower than a first magnetic field for moving magnetic particles closer to a substrate is not applied, on the substrate or in a storage container different from the substrate. In the measurement step, an elapsed time from a start reference time of the specific magnetic field state is measured. In the first application step, after the elapsed time reaches a predetermined time, the first magnetic field is applied, for a first application time, by a magnet, to the specimen solution introduced to the substrate.

Abstract: A particle including a polymer which has a repeating unit derived from a vinyl-based monomer. The particle has a specific structure containing a carboxy group, and a surface of the particle contains a water-soluble polymer.

Abstract: Provided is a magnetic particle having high magnetic field responsiveness in detection of a substance to be measured, such as an antigen or an antibody, from a specimen. The magnetic particle includes a magnetic core particle and a polymer layer arranged on a surface of the magnetic core particle. The magnetic core particle contains an aggregation of a plurality of magnetic nanoparticles. The polymer layer contains a polymer having at least one kind of functional group selected from the group consisting of: a carboxyl group; an amino group; a thiol group; an epoxy group; a maleimide group; and a succinimidyl group.

Abstract: Provided are a reagent and a measurement method for enabling a specimen test based on polarization anisotropy to be performed with high sensitivity and within a short period of time. Specifically, provided is an analysis method including measuring a value (R) for polarization anisotropy through use of a luminescent reagent that binds with a target substance, the analysis method including: a reaction step including mixing a sample containing the target substance with the luminescent reagent and a sensitizer, and subjecting the mixture to a reaction to obtain a reaction liquid; and a measurement step of measuring the R of the reaction liquid, the luminescent reagent including a luminescent particle substrate and a hydrophilic layer arranged on an outside of the luminescent particle substrate, the sensitizer containing a hydrophilic polymer.

Abstract: To perform measurement based on polarization anisotropy in which a reaction between a target substance and a luminescent reagent is performed within a short period of time, and in which high-sensitivity measurement can be performed, provided is an analysis method including measuring a value (R) for polarization anisotropy through use of a luminescent reagent that reacts with a target substance, to thereby determine at least any one of the presence or absence of the target substance and a concentration of the target substance, the analysis method including: a reaction step of mixing a sample containing the target substance with the luminescent reagent, and subjecting the mixture to a reaction to obtain a reaction liquid; a dilution step of diluting the reaction liquid to obtain a diluted liquid; and a measurement step of measuring the R of the diluted liquid, the luminescent reagent including luminescent particles.

Abstract: To provide a method for producing a particle that can suppress non-specific adsorption without using BSA. A method for producing a particle, including: a first step of mixing a radically polymerizable monomer, an organic silane compound having a silicon atom to which an alkoxy group is bonded and having radical polymerizability, a radical polymerization initiator, a water-soluble polymer, and an aqueous medium to prepare an emulsion; and a second step of adding a specific reactive compound after the first step.

Abstract: Provided is a magnetic particle excellent in detection speed when a substance to be measured, such as an antigen or an antibody, is detected from a specimen. The particle includes a magnetic particle containing a magnetic material, wherein the magnetic particle has a resin on a surface, wherein the particle has a volume average particle diameter of 0.4 ?m or more and 1.5 ?m or less, wherein the particle has a density of 5.1 g/cm3 or more and 10.0 g/cm3 or less, and wherein the resin has a functional group capable of binding a ligand.

Abstract: A precursor sol of aluminum oxide contains a polycondensate formed by the hydrolysis of an aluminum alkoxide or an aluminum salt, a solvent, and an organic aluminum compound having a specific structure. An optical member is produced by a process including a step of immersing an aluminum oxide film in a hot water with a temperature of 60° C. to 100° C. to form a textured structure made of aluminum oxide crystals, the aluminum oxide film being formed by feeding the precursor sol of aluminum oxide onto a base. A method for producing an optical member includes a step of immersing an aluminum oxide film in a hot water with a temperature of 60° C. to 100° C. to form a textured structure made of aluminum oxide crystals, the aluminum oxide film being formed by feeding the precursor sol of aluminum oxide onto a base.

Abstract: A precursor sol of aluminum oxide contains a polycondensate formed by the hydrolysis of an aluminum alkoxide or an aluminum salt, a solvent, and an organic aluminum compound having a specific structure. An optical member is produced by a process including a step of immersing an aluminum oxide film in a hot water with a temperature of 60° C. to 100° C. to form a textured structure made of aluminum oxide crystals, the aluminum oxide film being formed by feeding the precursor sol of aluminum oxide onto a base. A method for producing an optical member includes a step of immersing an aluminum oxide film in a hot water with a temperature of 60° C. to 100° C. to form a textured structure made of aluminum oxide crystals, the aluminum oxide film being formed by feeding the precursor sol of aluminum oxide onto a base.

Abstract: A precursor sol of aluminum oxide contains a polycondensate formed by the hydrolysis of an aluminum alkoxide or an aluminum salt, a solvent, and an organic aluminum compound having a specific structure. An optical member is produced by a process including a step of immersing an aluminum oxide film in a hot water with a temperature of 60° C. to 100° C. to form a textured structure made of aluminum oxide crystals, the aluminum oxide film being formed by feeding the precursor sol of aluminum oxide onto a base. A method for producing an optical member includes a step of immersing an aluminum oxide film in a hot water with a temperature of 60° C. to 100° C. to form a textured structure made of aluminum oxide crystals, the aluminum oxide film being formed by feeding the precursor sol of aluminum oxide onto a base.

Abstract: There are provided an optical member having a low reflectance and a good dustproof property and an image pickup apparatus. A plurality of projections are formed on a surface of a low-refractive-index layer disposed on a base and having a refractive index lower than that of the base so that a distance between peaks of the projections is 50 nm or more and 600 nm or less. An occupied area percentage at a depth of 15 nm in a direction toward the base from a peak farthest from the base among the peaks of the projections is 40% or less. An average of minor axis lengths of the projections at a depth of 5 nm or more and 15 nm or less in the direction is 15 nm or more.

Abstract: There is provided an optical member having a low reflectance and a good dustproof property. An optical member includes a base and a low-refractive-index layer disposed on the base and containing particles having a refractive index lower than that of the base. A plurality of projections are formed on a surface of the low-refractive-index layer. The width of the projections is 5 nm or more and 80 nm or less and the distance between the projections is 80 nm or more and 250 nm or less.

Abstract: An optical member includes a glass substrate and an antireflection film disposed on a surface of the glass substrate. The antireflection film includes an oxide layer mainly composed of aluminum oxide and having a textured shape in a surface and an intermediate layer disposed between the glass substrate and the oxide layer. The intermediate layer includes sheet-like crystals that are stacked so that their surfaces are parallel to the surface of the substrate.

Abstract: A method for manufacturing a patterned structural body by which a patterned structural body having a micropattern can be manufactured, a metal structural body-containing polymer film that can be used in the manufacture of the patterned structural body, and a method for manufacturing the polymer film are provided. The metal structural body-containing polymer film comprises a polymer film that includes a block copolymer having an ion-conductive segment and a non-ion-conductive segment and has a microphase-separated structure including ion-conductive domains and non-ion-conductive domains, and a metal structural body localized at the ion-conductive domains.

Abstract: To provide an optical member in which crystallization is suppressed and which has a porous glass layer on a base material. An optical member has a base material 1 and a porous glass layer 2 which is formed on the base material 1 and has a three-dimensional through pore, in which the existence ratio of crystals of 0.2 micrometer or more in the porous glass layer 2 is 1.0% or lower.

Abstract: A method for manufacturing a patterned structural body by which a patterned structural body having a micropattern can be manufactured, a metal structural body-containing polymer film that can be used in the manufacture of the patterned structural body, and a method for manufacturing the polymer film are provided. The metal structural body-containing polymer film comprises a polymer film that includes a block copolymer having an ion-conductive segment and a non-ion-conductive segment and has a microphase-separated structure including ion-conductive domains and non-ion-conductive domains, and a metal structural body localized at the ion-conductive domains.

Abstract: A method of producing a material capable of electrochemically storing and releasing a large amount of lithium ions is provided. The material is used as an electrode material for a negative electrode, and includes silicon or tin primary particles composed of crystal particles each having a specific diameter and an amorphous surface layer formed of at least a metal oxide, having a specific thickness. Gibbs free energy when the metal oxide is produced by oxidation of a metal is smaller than Gibbs free energy when silicon or tin is oxidized, and the metal oxide has higher thermodynamic stability than silicon oxide or tin oxide. The method of producing the electrode material includes reacting silicon or tin with a metal oxide, reacting a silicon oxide or a tin oxide with a metal, or reacting a silicon compound or a tin compound with a metal compound to react with each other.