Patents by Inventor Noritada Sato
Noritada Sato has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 10308604Abstract: The present invention provides a method for producing an atropisomer of a pyrrole derivative having excellent mineralocorticoid receptor antagonistic activity, and an intermediate thereof. A method for producing an atropisomer of a pyrrole derivative using a compound represented by (B) [wherein R1 represents a C1-C4 alkyl group, and R2 represents a 2-hydroxyethyl group or a carboxymethyl group] as a production intermediate.Type: GrantFiled: April 11, 2018Date of Patent: June 4, 2019Assignee: Daiichi Sankyo Company, LimitedInventors: Masashi Watanabe, Hiroshi Nagasawa, Noritada Sato
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Publication number: 20180230095Abstract: The present invention provides a method for producing an atropisomer of a pyrrole derivative having excellent mineralocorticoid receptor antagonistic activity, and an intermediate thereof. A method for producing an atropisomer of a pyrrole derivative using a compound represented by (B) [wherein R1 represents a C1-C4 alkyl group, and R2 represents a 2-hydroxyethyl group or a carboxymethyl group] as a production intermediate.Type: ApplicationFiled: April 11, 2018Publication date: August 16, 2018Applicant: Daiichi Sankyo Company, LimitedInventors: Masashi Watanabe, Hiroshi Nagasawa, Noritada Sato
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Patent number: 10005725Abstract: The present invention provides a method for producing an atropisomer of a pyrrole derivative having excellent mineralocorticoid receptor antagonistic activity, and an intermediate thereof. A method for producing an atropisomer of a pyrrole derivative using a compound represented by (B) [wherein R1 represents a C1-C4 alkyl group, and R2 represents a 2-hydroxyethyl group or a carboxymethyl group] as a production intermediate.Type: GrantFiled: September 8, 2017Date of Patent: June 26, 2018Assignee: Daiichi Sankyo Company, LimitedInventors: Masashi Watanabe, Hiroshi Nagasawa, Noritada Sato
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Publication number: 20170369438Abstract: The present invention provides a method for producing an atropisomer of a pyrrole derivative having excellent mineralocorticoid receptor antagonistic activity, and an intermediate thereof. A method for producing an atropisomer of a pyrrole derivative using a compound represented by (B) [wherein R1 represents a C1-C4 alkyl group, and R2 represents a 2-hydroxyethyl group or a carboxymethyl group] as a production intermediate.Type: ApplicationFiled: September 8, 2017Publication date: December 28, 2017Applicant: Daiichi Sankyo Company, LimitedInventors: Masashi Watanabe, Hiroshi Nagasawa, Noritada Sato
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Patent number: 9776961Abstract: The present invention provides a production intermediate of an atropisomer of a pyrrole derivative having excellent mineralocorticoid receptor antagonistic activity, a method for producing the same, and a crystal thereof. A method for producing an atropisomer of a pyrrole derivative including a step of resolving a compound represented by the following general formula (I) [wherein R1 represents a methyl group or a trifluoromethyl group, R2 represents a hydrogen atom or a C1-C3 alkoxy group, and n represents an integer selected from 1 to 3] into its atropisomers, characterized by using an optically active amine having a cinchonine skeletal formula, and a crystal of (S)-1-(2-hydroxyethyl)-4-methyl-N-[4-(methylsulfonyl)phenyl]-5-[2-(trifluoromethyl)phenyl]-1H-pyrrole-3-carboxamide.Type: GrantFiled: April 28, 2017Date of Patent: October 3, 2017Assignee: Daiichi Sankyo Company, LimitedInventors: Masashi Watanabe, Takahiro Okachi, Michiaki Kawahara, Hiroshi Nagasawa, Noritada Sato, Takashi Takita, Gen Hasegawa
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Patent number: 9765025Abstract: The present invention provides a method for producing an atropisomer of a pyrrole derivative having excellent mineralocorticoid receptor antagonistic activity, and an intermediate thereof. A method for producing an atropisomer of a pyrrole derivative using a compound represented by (B) [wherein R1 represents a C1-C4 alkyl group, and R2 represents a 2-hydroxyethyl group or a carboxymethyl group] as a production intermediate.Type: GrantFiled: February 12, 2016Date of Patent: September 19, 2017Assignee: Daiichi Sankyo Company, LimitedInventors: Masashi Watanabe, Hiroshi Nagasawa, Noritada Sato
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Publication number: 20170233341Abstract: The present invention provides a production intermediate of an atropisomer of a pyrrole derivative having excellent mineralocorticoid receptor antagonistic activity, a method for producing the same, and a crystal thereof. A method for producing an atropisomer of a pyrrole derivative including a step of resolving a compound represented by the following general formula (I) [wherein R1 represents a methyl group or a trifluoromethyl group, R2 represents a hydrogen atom or a C1-C3 alkoxy group, and n represents an integer selected from 1 to 3] into its atropisomers, characterized by using an optically active amine having a cinchonine skeletal formula, and a crystal of (S)-1-(2-hydroxyethyl)-4-methyl-N-[4-(methylsulfonyl)phenyl]-5-[2-(trifluoromethyl)phenyl]-1H-pyrrole-3-carboxamide.Type: ApplicationFiled: April 28, 2017Publication date: August 17, 2017Applicant: Daiichi Sankyo Company, LimitedInventors: Masashi Watanabe, Takahiro Okachi, Michiaki Kawahara, Hiroshi Nagasawa, Noritada Sato, Takashi Takita, Gen Hasegawa
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Patent number: 9676713Abstract: The present invention provides a production intermediate of an atropisomer of a pyrrole derivative having excellent mineralocorticoid receptor antagonistic activity, a method for producing the same, and a crystal thereof. A method for producing an atropisomer of a pyrrole derivative including a step of resolving a compound represented by the following general formula (I) [wherein R1 represents a methyl group or a trifluoromethyl group, R2 represents a hydrogen atom or a C1-C3 alkoxy group, and n represents an integer selected from 1 to 3] into its atropisomers, characterized by using an optically active amine having a cinchonine skeletal formula, and a crystal of (S)-1-(2-hydroxyethyl)-4-methyl-N-[4-(methylsulfonyl)phenyl]-5-[2-(trifluoromethyl)phenyl]-1H-pyrrole-3-carboxamide.Type: GrantFiled: November 15, 2016Date of Patent: June 13, 2017Assignee: Daiichi Sankyo Company, LimitedInventors: Masashi Watanabe, Takahiro Okachi, Michiaki Kawahara, Hiroshi Nagasawa, Noritada Sato, Takashi Takita, Gen Hasegawa
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Publication number: 20170057915Abstract: The present invention provides a production intermediate of an atropisomer of a pyrrole derivative having excellent mineralocorticoid receptor antagonistic activity, a method for producing the same, and a crystal thereof. A method for producing an atropisomer of a pyrrole derivative including a step of resolving a compound represented by the following general formula (I) [wherein R1 represents a methyl group or a trifluoromethyl group, R2 represents a hydrogen atom or a C1-C3 alkoxy group, and n represents an integer selected from 1 to 3] into its atropisomers, characterized by using an optically active amine having a cinchonine skeletal formula, and a crystal of (S)-1-(2-hydroxyethyl)-4-methyl-N-[4-(methylsulfonyl)phenyl]-5-[2-(trifluoromethyl)phenyl]-1H-pyrrole-3-carboxamide.Type: ApplicationFiled: November 15, 2016Publication date: March 2, 2017Applicant: Daiichi Sankyo Company, LimitedInventors: Masashi Watanabe, Takahiro Okachi, Michiaki Kawahara, Hiroshi Nagasawa, Noritada Sato, Takashi Takita, Gen Hasegawa
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Patent number: 9499483Abstract: The present invention provides a production intermediate of an atropisomer of a pyrrole derivative having excellent mineralocorticoid receptor antagonistic activity, a method for producing the same, and a crystal thereof. A method for producing an atropisomer of a pyrrole derivative including a step of resolving a compound represented by the following general formula (I) [wherein R1 represents a methyl group or a trifluoromethyl group, R2 represents a hydrogen atom or a C1-C3 alkoxy group, and n represents an integer selected from 1 to 3] into its atropisomers, characterized by using an optically active amine having a cinchonine skeletal formula, and a crystal of (S)-1-(2-hydroxyethyl)-4-methyl-N-[4-(methylsulfonyl)phenyl]-5-[2-(trifluoromethyl)phenyl]-1H-pyrrole-3-carboxamide.Type: GrantFiled: October 9, 2015Date of Patent: November 22, 2016Assignee: Daiichi Sankyo Company, LimitedInventors: Masashi Watanabe, Takahiro Okachi, Michiaki Kawahara, Hiroshi Nagasawa, Noritada Sato, Takashi Takita, Gen Hasegawa
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Publication number: 20160237034Abstract: The present invention provides a method for producing an atropisomer of a pyrrole derivative having excellent mineralocorticoid receptor antagonistic activity, and an intermediate thereof. A method for producing an atropisomer of a pyrrole derivative using a compound represented by (B) [wherein R1 represents a C1-C4 alkyl group, and R2 represents a 2-hydroxyethyl group or a carboxymethyl group] as a production intermediate.Type: ApplicationFiled: February 12, 2016Publication date: August 18, 2016Applicant: Daiichi Sankyo Company, LimitedInventors: Masashi Watanabe, Hiroshi Nagasawa, Noritada Sato
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Publication number: 20160096803Abstract: The present invention provides a production intermediate of an atropisomer of a pyrrole derivative having excellent mineralocorticoid receptor antagonistic activity, a method for producing the same, and a crystal thereof. A method for producing an atropisomer of a pyrrole derivative including a step of resolving a compound represented by the following general formula (I) [wherein R1 represents a methyl group or a trifluoromethyl group, R2 represents a hydrogen atom or a C1-C3 alkoxy group, and n represents an integer selected from 1 to 3] into its atropisomers, characterized by using an optically active amine having a cinchonine skeletal formula, and a crystal of (S)-1-(2-hydroxyethyl)-4-methyl-N-[4-(methylsulfonyl)phenyl]-5-[2-(trifluoromethyl)phenyl]-1H-pyrrole-3-carboxamide.Type: ApplicationFiled: October 9, 2015Publication date: April 7, 2016Applicant: Daiichi Sankyo Company, LimitedInventors: Masashi Watanabe, Takahiro Okachi, Michiaki Kawahara, Hiroshi Nagasawa, Noritada Sato, Takashi Takita, Gen Hasegawa
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Patent number: 7547790Abstract: An optically active 4,4-di-substituted oxazolidine compound having the formula (I) wherein R1 represents a substituted C1-C3 alkyl group, a substituted C2-C3 alkenyl group, a formyl group, a hydroxymethyl group, a group of the formula COOR, a halogenated methyl group, a phosphonium methyl group; R represents a C1-C6 alkyl group, a C2-C6 alkenyl group, a phenyl group or a benzyl group; R2 represents a C1-C6 alkyl group, a C3-C10 cycloalkyl group, or a phenyl group; R3 represents a C2-C6 alkanoyl group, a C1-C6 alkyloxycarbonyl group, a benzoyl group, a phenyloxycarbonyl group or a benzyloxycarbonyl group and R4 represents a C1-C6 alkyl group or a C2-C6 alkenyl group.Type: GrantFiled: October 26, 2005Date of Patent: June 16, 2009Assignee: Sankyo Company, LimitedInventors: Toshihiko Onoda, Yoshitaka Nakamura, Makoto Yamaoka, Tadahiro Takeda, Noritada Sato, Masayoshi Jin
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Publication number: 20080108828Abstract: An optically active 4,4-di-substituted oxazolidine compound having the formula (I) wherein R1 represents a substituted C1-C3 alkyl group, a substituted C2-C3 alkenyl group, a formyl group, a hydroxymethyl group, a group of the formula COOR, a halogenated methyl group, a phosphonium methyl group; R represents a C1-C6 alkyl group, a C2-C6 alkenyl group, a phenyl group or a benzyl group; R2 represents a C1-C6 alkyl group, a C3-C10 cycloalkyl group, or the like or a phenyl group; R3 represents a C2-C6 alkanoyl group, a C1-C6 alkyloxycarbonyl group, a benzoyl group, a phenyloxycarbonyl group or a benzyloxycarbonyl group and R4 represents a C1-C6 alkyl group or a C2-C6 alkenyl group.Type: ApplicationFiled: October 26, 2005Publication date: May 8, 2008Inventors: Toshihiko Onoda, Yoshitaka Nakamura, Makoto Yamaoka, Tadahiro Takeda, Noritada Sato, Masayoshi Jin
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Patent number: 5156979Abstract: A semiconductor-based radiation-detector element particularly adapted to neutron detection, and the method for making the same, in which a high sensitivity single-crystal semiconductor substrate has diffused therein at-least-one region of .sup.3 He gas, which remain resident therein, whereby, upon application of an inverse bias to the junction in the semiconductor substrate, the colliding of incident neutrons with the resident .sup.3 He gas results in a reaction which produces hole-electron pairs in the depletion layer within the semiconductor, those hole-electron pairs producing output electrical pulses which appear at the output terminals of the detector for utilization by detection and measuring apparatus connected to the semiconductor-based radiation-detector element.Type: GrantFiled: May 7, 1991Date of Patent: October 20, 1992Assignee: Fuji Electric Co., Ltd.Inventors: Noritada Sato, Toshikazu Suzuki, Osamu Ishiwata
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Patent number: 5019886Abstract: A semiconductor-based radiation-detector element particularly adapted to neutron detection, and the method for making the same, in which a high sensitivity single-crystal semiconductor substrate has diffused therein at-least-one region of .sup.3 He gas, which remains resident therein, whereby, upon application of an inverse bias to the junction in the semiconductor substrate, the colliding of incident neutrons with the resident .sup.3 He gas results in a reaction which produces hole-electron pairs in the depletion layer within the semiconductor, those hole-electron pairs producing output electrical pulses which appear at the output terminals of the detector for utilization by detection and measuring apparatus connected to the semiconductor-based radiation-detector element.Type: GrantFiled: December 12, 1988Date of Patent: May 28, 1991Assignee: Fuji Electric Co., Ltd.Inventors: Noritada Sato, Toshikazu Suzuki, Osamu Ishiwata
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Patent number: 4960436Abstract: A radiation or light detecting semiconductor element comprises a p-type monocrystalline silicon substrate having a high specific resistance of about 10,000 ohm-cm, a stopper layer formed in a part of a first principal surface of the substrate and diffused to provide a p-type conductivity material, an electrode diffusion layer of p.sup.+ type material formed in at least part of the remaining part of the first principal surface not provided with the stopper layer, so as to be diffused into an n-type conductivity material, a metal (silicon) oxide layer formed on substantially the entire first principal substrate surface, a first aluminum electrode provided through the metal oxide layer and electrically connected to the electrode diffusion layer, and a second electrode of laminated Cr-Ni-Au deposited electrically conductively on a second principal surface of the substrate. A method for producing the element is also disclosed.Type: GrantFiled: February 6, 1985Date of Patent: October 2, 1990Assignee: Fuji Electric Corporate Research & DevelopmentInventor: Noritada Sato
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Patent number: 4896200Abstract: A semiconductor-based radiation detector comprising a semiconductor substrate and an amorphous semiconductor layer formed on one surface of the substrate, one electrode being applied to the substrate and one to the amorphous layer, the electrodes formed on the amorphous semiconductor layer consisting of closely spaced, interconnected conductive strips which are substantially uniformly arranged over the entire radiation-incident surface of the amorphous semiconductor layer whereby the electrostatic capacitance appearing between the electrodes of the detector is significantly reduced without significantly changing the area of the detector that responds to radiation.Type: GrantFiled: February 1, 1988Date of Patent: January 23, 1990Assignee: Fuji Electric Co., Ltd.Inventors: Yasukazu Seki, Noritada Sato, Masaya Yabe
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Patent number: 4835587Abstract: A semiconductor device for detecting gamma radiation displaying superior linearity of response to radiation without showing any energy dependency even if the gamma rays have the high energy is formed using an annular depletion region surrounded by non-depletion regions. The size of the regions is selected so that the distance from the edge of the depletion to the most distant point of the non-depletion region is at least about equal to the mean range of the highest energy gamma ray to be measured.Type: GrantFiled: October 1, 1987Date of Patent: May 30, 1989Assignee: Fuji Electric Co., Ltd.Inventors: Noritada Sato, Yasukazu Seki
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Patent number: 4768072Abstract: In the typical embodiments of the invention described in the specification, a radiation detector has a single crystal silicon substrate coated with an amorphous semiconductor film containing silicon and carbon, metal electrodes being provided. Amorphous layers are formed by a plasma CVD method using mixtures of monosilane gas and acetylene or tetrafluorocarbon gas at a pressure of 10 Torr with an applied voltage of 400-800 volts providing increased band gaps and higher resistivity to reduce current leakage.Type: GrantFiled: October 2, 1986Date of Patent: August 30, 1988Assignees: Fuji Electric Corporate Research and Development Co., Ltd., Fuji Electric Co. Ltd.Inventors: Yasakazu Seki, Noritada Sato, Masaya Yabe