Abstract: Derivatives of milbemycins D, A.sub.3 and A.sub.4 and of the corresponding sec-butyl compound have a halogen atom at the 13-position; at the 5-position, they have an oxygen (keto) atom, an oxime group or a substituted oxime group. They may be prepared from known compounds by any appropriate combination of halogenation, ketonization and oximation.

Abstract: 5-Carbonate derivatives of milbemycins A.sub.3, A.sub.4 and A.sub.5 have valuable acaricidal, anthelmintic and other activities, especially against endo- and exoparasites.

Abstract: Oxime derivatives of 5-didehydromilbemycins A.sub.3, A.sub.4 and D are represented by the formula: ##STR1## (wherein R.sup.1 represents methyl, ethyl or isopropyl, and R.sup.2 represents hydrogen, lower alkyl, optionally substituted aralkyl or --CH.sub.2 COOR.sup.3, wherein R.sup.3 represents hydrogen or lower alkyl). These and their salts and esters have valuable anthelmintic, acaricidal and insecticidal activity.

Abstract: The combined administration of:(a) one or more macrolide anthelmintic agents selected from the group consisting of B-41 series antibiotics, C-076 series antibiotics and 22,23-dihydro C-076 derivatives; and(b) one or more anthelmintic agents selected from the group consisting of benzimidazole, salicylamide and isoquinoline compounds,has been bound to exhibit enhanced anthelmintic activity as compared with the additive use of the individual compounds.

Abstract: ML-236B carboxylic acid derivatives having the formula ##STR1## wherein R represents an alkyl group, a benzyl group optionally substituted with alkyl, alkoxy or halogen or a phenacyl group optionally substituted with alkyl, alkoxy or halogen; a group of 1/n M in which M represents a metal and n represents a valency of said metal; or a group of AH.sup.+ in which A represents an amino acid. These derivatives are derived from ML-236B by conventional procedures and have an antihyperlipemic activity.

Abstract: Pyridine derivatives having the formula ##STR1## wherein R.sub.1 is an alkyl group having 1 to 3 carbon atoms; R.sub.2 is hydrogen atom or an alkyl group having 1 to 3 carbon atoms; R.sub.3 is hydrogen atom, an alkyl group having 1 to 4 carbon atoms, an alkenyl group having 3 or 4 carbon atoms, an alkyl group having 1 or 2 carbon atoms and hydroxy as a substituent, an alkanoyl group having 1 to 18 carbon atoms, an alkenoyl group having 3 to 11 carbon atoms, an aromatic acyl group having 6 or 10 carbon atoms in the aromatic ring and optionally alkyl, alkoxy, acetylamino, cyano or halogen as a substituent, a heterocyclic acyl group, an alkylcarbamoyl group having 1 to 4 carbon atoms in the alkyl moiety, an allylcarbamoyl group or hydroxy group; n is an integer of 0 to 2 inclusive; and, when n is 2, R.sub.1 's may be the same or different; provided that when R.sub.2 is said alkyl group having 1 to 3 carbon atoms, R.sub.3 is said alkyl group having 1 to 4 carbon atoms.

Abstract: Pyridine derivatives having the formula ##STR1## wherein R.sub.1 represents hydrogen atom, amino group or a group ##STR2## in which R.sub.5 and R.sub.6 may be the same or different and each represents an alkyl group of 1 to 4 carbon atoms or R.sub.5 is hydrogen atom and R.sub.6 represents an alkyl group of 1 to 4 carbon atoms, an alkenyl group of 3 or 4 carbon atoms or a benzyl group optionally substituted with halogen, cyano, alkyl of 1 to 4 carbon atoms or alkoxy of 1 to 4 carbon atoms;R.sub.2 represents nitro group, amino group or an alkylamino group of 1 to 3 carbon atoms;R.sub.3 and R.sub.

Abstract: Use of dithiocarbamic acid derivatives having the structure ##STR1## in which R.sub.1, R.sub.2 and R.sub.3 are various organic radicals as preventive and curative agents against mycoplasmosis. These derivatives are prepared from the starting materials having the structure ##STR2## by reaction with carbon disulfide or from the starting materials having the structure ##STR3## BY REACTION WITH R.sub.3 -halide.

Abstract: Pyridine derivatives having the formula ##STR1## wherein R.sub.1 is an alkyl group having 1 to 3 carbon atoms; R.sub.2 is hydrogen atom or an alkyl group having 1 to 3 carbon atoms; R.sub.3 is hydrogen atom, an alkyl group having 1 to 4 carbon atoms, an alkenyl group having 3 or 4 carbon atoms, an alkyl group having 1 or 2 carbon atoms and hydroxy as a substituent, an alkanoyl group having 1 to 18 carbon atoms, an alkenoyl group having 3 to 11 carbon atoms, an aromatic acyl group having 6 or 10 carbon atoms in the aromatic ring and optionally alkyl, alkoxy, acetylamino, cyano or halogen as a substituent, a heterocyclic acyl group, an alkylcarbamoyl group having 1 to 4 carbon atoms in the alkyl moiety, an allylcarbamoyl group or hydroxy group; n is an integer of 0 to 2 inclusive; and, when n is 2, R.sub.1 's may be the same or different; provided that when R.sub.2 is said alkyl group having 1 to 3 carbon atoms, R.sub.3 is said alkyl group having 1 to 4 carbon atoms.

Abstract: Anticoccidial compositions which comprise as active ingredient pyridine derivatives having the formula ##STR1## wherein R.sub.1 is hydrogen atom, a halomethyl group or methyl group;R.sub.2 is hydrogen atom or an alkyl group of 1-3 carbon atoms;R.sub.3 is hydrogen atom, an alkyl group of 1-3 carbon atoms, allyl group, an alkyl group having 2 or 3 carbon atoms and alkoxy of 1 or 2 carbon atoms as a substituent, an alkyl group having 1-3 carbon atoms and hydroxy as a substituent, an alkanoyl group of 1-18 carbon atoms, a haloacetyl group, an alkenoyl group of 3-11 carbon atoms, an aromatic acyl group, a heterocyclic acyl group, an N-alkylcarbamoyl group of 1-4 carbon atoms in the alkyl moiety or hydroxy group;Provided that when R.sub.2 is said alkyl group of 1-3 carbon atoms, R.sub.3 is said alkyl group of 1-3 carbon atoms and inorganic acid addition salts thereof.

Abstract: An anticoccidial composition which comprises a compound of the formula ##SPC1##Intimately dispersed in an inert edible carrier, wherein R.sub.1 and R.sub.2 are each hydrogen, an aliphatic acyl group, an aromatic acyl group or a heterocyclic acyl group, and at least R.sub.1 and R.sub.2 is said heterocyclic acyl group; or a salt thereof.The composition is a preventive and curative anticoccidial agent for poultry and domestic animals. Particularly, it shows a significant activity against chronic coccidiosis caused by Eimeria acervulina.The composition is less toxic for animals, besides it has an advantage that it is also effective for coccidiosis caused by coccidia resistant to the known anticoccidial agents.

Abstract: Fungicidal compositions for topical treatment of dermatomycosis of animals which contain as active ingredient an antibiotic substance siccanin, preferably in the form of an aerosol or an ointment.

Abstract: Antibiotic substance named "Pholipomycin" which is useful as a growth promoting agent for domestic animals, poultries and the like and produced by the cultivation of a new microorganism, Streptomyces lividoclavatus strain No. 3176, NRRL 8022.

Abstract: A composition which comprises a pyridinol derivative of the formula ##SPC1##Intimately dispersed in an inert edible carrier, wherein R.sub.1 and R.sub.2 may be the same or different and each represents a hydrogen atom; a lower alkyl group, an aralkyl group, an aliphatic, an aromatic or a heterocyclic acyl group; an alkoxycarbonyl group; an aralkoxycarbonyl group; an aryloxycarbonyl group; a N-substituted carbonyl group; a N-substituted thiocarbonyl group; a phosphono group; or a salt thereof.The composition is a preventive and curative anticoccidial agent for poultry and domestic animals. Particularly, it shows a significant activity against chronic coccidiosis caused by Eimeria acervulina.The composition is less toxic for animals, besides it has an advantage that it is also effective for coccidiosis caused by coccidia resistant to the known anticoccidial agents.