Patents by Inventor Noriyoshi Sueda
Noriyoshi Sueda has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 5847123Abstract: Imide compounds having a propioloyl group or pharmaceutically acceptable salts thereof which exhibit potent activities to inhibit the production of Interleukin 1-.beta. and also the production of Tumor Necrosis Factor .alpha.. These imide compounds are useful as a prophylactic or therapeutic agent for inhibiting the production of Interleukin 1-.beta. and the production of Tumor Necrosis Factor .alpha., typically for such diseases as chronic rheumatism, sepsis, ulcerative colitis, Crohn's disease and many other related diseases in which Interleukin 1-.beta. and/or Tumor Necrosis Factor .alpha. would participate.Type: GrantFiled: July 1, 1997Date of Patent: December 8, 1998Assignee: Nisshin Flour Milling Co., Ltd.Inventors: Shinji Yokoyama, Noriyoshi Sueda, Hiroaki Yamada, Ryotaro Kojima, Koichi Katsuyama
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Patent number: 5621010Abstract: Urea derivatives of formula (I) ##STR1## wherein the valuable groups are as defined in the specification, which possess both an ACAT inhibitory activity and an antioxidative activity. Those derivatives are useful in the prophylaxis and treatment of hypercholesterolemia and atherosclerosis.Type: GrantFiled: May 18, 1994Date of Patent: April 15, 1997Assignee: Nisshin Flour Milling Co., Ltd.Inventors: Noriyoshi Sueda, Kazuhiko Yamada, Makoto Yanai, Katsutoshi Miura, Masato Horigome, Norio Oshida, Shigeru Hiramoto, Koichi Katsuyama, Fumihisa Nakata, Nobuhiro Kinoshita, Yoko Tsukada
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Patent number: 5576335Abstract: Urea derivatives of formula (1) ##STR1## wherein the valuable groups are as defined in the specification, which possess both an ACAT inhibitory activity and an antioxidative activity. Those derivatives are useful in the prophylaxis and treatment of hypercholesterolemia and atherosclerosis.Type: GrantFiled: September 29, 1994Date of Patent: November 19, 1996Assignee: Nisshin Flour Milling Co., Ltd.Inventors: Noriyoshi Sueda, Kazuhiko Yamada, Makoto Yanai, Katsutoshi Miura, Masato Horigome, Norio Oshida, Shigeru Hiramoto, Koichi Katasuyama, Fumihisa Nakata, Nobuhiro Kinoshita, Yoko Tsukada
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Patent number: 5116855Abstract: Disclosed is a rhodanine derivative of formula (I).A rhodanine derivative of formula (I) ##STR1## wherein R.sup.1 is hdyrogen, C.sub.1 -C.sub.8 alkyl, carboxyl(C.sub.1 -C.sub.4)alkyl or (C.sub.1 -C.sub.4)alkoxycarbonyl(C.sub.1 -C.sub.4)alkyl;R.sup.2 is --CH.sub.2 --CH.sub.2 --R.sup.3, CH.dbd.CH.sub.m R.sup.3 (m is 0 or 1), ##STR2## (R is C.sub.1 -C.sub.3 alkyl) or --CH.sub.2n CONHR.sup.4 (n is 0 or 1-4); R.sup.3 is a thienyl or furyl group which may be substituted by C.sub.1 -C.sub.3 alkyl or halogen; a pyrrolyl group which may be substituted by carboxy(C.sub.1 -C.sub.3)alkyl on the nitrogen atom; or a phenyl group which may be substituted by one or more substituents selected from the group consisting of C.sub.1 -C.sub.3 alkyl, C.sub.1 -C.sub.3 alkoxy, hydroxyl, halogen, trifluoromethyl, carboxyl, (C.sub.1 -C.sub.3)alkoxycarbonyl, cyano, carboxy(C.sub.1 -C.sub.3)alkoxy, (C.sub.1 -C.sub.6)alkoxycarbonyl(C.sub.1 -C.sub.3)alkoxy, benzyloxycarbonyl(C.sub.1 -C.sub.3)alkoxy, piperidinylcarbonyl(C.sub.1 -C.sub.Type: GrantFiled: May 11, 1990Date of Patent: May 26, 1992Assignee: Nisshin Flour Milling Co., Ltd.Inventors: Hitoshi Inoue, Hiroki Kato, Noriyoshi Sueda, Yoshiyuki Tahara, Nobuhiro Kinoshita
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Patent number: 4886803Abstract: Compounds are described of formula (I) ##STR1## wherein R.sup.1 is a hydrogen atom, an alkyl group, an alkoxy group, a dialkylamino group or a halogen atom; n is 1 to 4; R.sup.2 is a hydrogen atom, an alkyl group, an unsubstituted or substituted aminoalkyl group, an acyl group, an unsubstituted or substituted aralkyl group, a carboxyalkyl group, an alkoxycarbonyalkyl group or ##STR2## wherein X is an unsubstituted or substituted-phenyl, -benzyl, -benzoyl or -furoyl group; A is -NR.sup.3 - where R.sup.3 is hydrogen or alkyl, an alkylene or an alkylidene; and B is a heterocyclic group selected from triazolyl, pyridyl, pyridazinyl, pyrimidinyl, pyrazinyl, benzimidazolyl, benzothiazolyl, quinolyl and isoquinolyl, said heterocyclic group being optionally substituted by one or more alkyl, alkoxy, nitro or phenyl group, and the physiologically acceptable acid addition salts thereof. The compound of formula (I) are or cardiotonic activity and thus may be useful for the treatment of circulatory diseases.Type: GrantFiled: July 15, 1987Date of Patent: December 12, 1989Assignee: Nisshin Flour Milling Co., Ltd.Inventors: Noriyoshi Sueda, Yoshikuni Suzuki, Toshiji Sugai, Hiroaki Yamada, Makoto Yanai
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Patent number: 4659833Abstract: Four different optical isomers of a new compound, 1-[2'-(o-methoxyphenoxy)-1'-methylethylamino]-3-(4"-isocarbostyriloxy)-2-p ropanol are now provided as new substances. These four optical isomers are now named as (2R, 1'S)-1-[2'-(o-methoxyphenoxy)-1'-methylethylamino]-3-(4"-isocarbostyriloxy )-2-propanol, (2S, 1'S)-1-[2'-(o-methoxyphenoxy)-1'-methylethylamino]-3-(4"-isocarbostyriloxy )-2-propanol, (2S, 1'R)-1-[2'-(o-methoxyphenoxy)-1'-methylethylamino]-3-(4"-isocarbostyriloxy )-2-propanol, and (2R, 1'R)-1-[2'-(o-methoxyphenoxy)-1'-methylethylamino]-3-(4"-isocarbostyriloxy )-2-propanol, respectively. These four optical isomers have different activities for their .beta.-adrenergic-blocking effect and .alpha.-adrenergic-blocking effect and are useful as valuable agents for therapeutic treatment of various cardiovascular diseases, as compared to an optically inactive racemic mixture of said isomer compounds.Type: GrantFiled: May 8, 1985Date of Patent: April 21, 1987Assignee: Nisshin Flour Milling Co., Ltd.Inventors: Toshihiro Takahashi, Noriyoshi Sueda, Masahiro Tsuji, Yoshiyuki Tahara, Hiroyasu Koyama, Yoshikuni Suzuki, Masao Nagase, Toshiji Sugai
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Patent number: 4526893Abstract: Compounds of the structure ##STR1## wherein X, R.sub.1, R.sub.2, R.sub.3, R.sub.4, and R.sub.5 are as herein defined, effective as .beta.-blockers and hypotensive agents, are described.Type: GrantFiled: December 16, 1983Date of Patent: July 2, 1985Assignee: Nisshin Flour Milling Co., Ltd.Inventors: Toshihiro Takahashi, Noriyoshi Sueda, Masahiro Tsuji, Yoshiyuki Tahara, Hiroyasu Koyama, Yoshikuni Suzuki, Masao Nagase, Toshiji Sugai
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Patent number: 4521339Abstract: The disclosure describes a microbiological process for the preparation of mycotrien-related compounds.The compounds are isolated and characterized by structural formula and other identifying data.The compounds are useful in the treatment of tumors.Type: GrantFiled: November 24, 1982Date of Patent: June 4, 1985Assignee: Nisshin Flour Milling Co., Ltd.Inventors: Noboru Otake, Haruo Seto, Tetsuo Sasaki, Masanori Sugita, Yohei Natori, Noriyoshi Sueda
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Patent number: 4096338Abstract: 2-Hydroxy-butenoic acid derivatives of the general formula: ##STR1## are described. These compounds have antiphlogistic activity.Type: GrantFiled: November 18, 1976Date of Patent: June 20, 1978Assignee: Nisshin Flour Milling Co., Ltd.Inventors: Katsura Kogure, Noriyoshi Sueda, Sizuo Himoto, Youziro Yoshino, Kunio Nakagawa
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Patent number: 4042617Abstract: A process for preparing 3-methyl-3-(substituted aryl)-pyruvic acid compounds by treating a glycidic acid ester compound of the formula, ##STR1## wherein R.sup.1 is a 4-biphenylyl, 4-clyclohexylphenyl, 3-phenoxyphenyl, 4'-fluoro-4-biphenylyl, 2-fluoro-4-biphenylyl or 3-benzoylphenyl group and R.sup.2 is a lower alkyl group or its corresponding free acid with a Lewis acid to form a 2-hydroxy-3-(substituted aryl)-3-butenoic acid ester and treating the resulting ester in an alcohol with an alkali metal alcoholate to form the pyruvic acid compounds. If desired, the pyruvic acid compounds can then be saponified to compounds of the formula, ##STR2## wherein R.sup.1 is as previously defined and which compounds are useful as anti-inflammatory agents.Type: GrantFiled: July 28, 1975Date of Patent: August 16, 1977Assignee: Nisshin Flour Milling Co., Ltd.Inventors: Katsura Kogure, Noriyoshi Sueda, Sizuo Himoto, Youziro Yoshino, Kunio Nakagawa
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Patent number: 4016196Abstract: Process for preparing a 2-hydroxy-butenoic acid derivative of the general formula, ##STR1## wherein R.sup.1 is a group selected from aliphatic, alicyclic or aromatic radicals and R.sup.2 is a lower alkyl group by heating a glycidic acid derivative having the general formula, ##STR2## wherein R.sup.1 and R.sup.2 is as defined above or for preparing a pyruvic acid derivative of the general formula, ##STR3## wherein R.sup.1 and R.sup.2 are as defined above by heating the glycidic acid derivative of the above mentioned formula (I) or the 2-hydroxy-butenoic acid derivative of formula (II) in the presence of an electrophilic agent.Type: GrantFiled: July 28, 1975Date of Patent: April 5, 1977Assignee: Nisshin Flour Milling Co., Ltd.Inventors: Katsura Kogure, Noriyoshi Sueda, Sizuo Himoto, Youziro Yoshino, Kunio Nakagawa
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Patent number: 4007217Abstract: Process for producing a 2-hydroxy-3-butenoic acid derivative having the formula ##STR1## wherein R.sup.1 is an aliphatic, alicyclic or aromatic group and R.sup.2 is a lower alkyl group by treating a glycidic acid ester derivative having the formula ##STR2## wherein R.sup.1 and R.sup.2 are as defined above in the presence of an acid.Type: GrantFiled: July 28, 1975Date of Patent: February 8, 1977Assignee: Nisshin Flour Milling Co., Ltd.Inventors: Katsura Kogure, Noriyoshi Sueda, Sizuo Himoto, Youziro Yoshino, Kunio Nakagawa