Patents by Inventor Norman A. Abood

Norman A. Abood has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • GPE analogs and peptidominetics
    Patent number: 7041314
    Abstract: This invention relates to analogs and peptidomimetics of glycyl-L-prolyl-L-glutamic acid (GPE). In particular, this invention relates to GPE analogs and peptidomimetics that are anti-apoptotic and anti-necrotic, to methods of making them, to pharmaceutical compositions containing them, and to their use.
    Type: Grant
    Filed: May 24, 2002
    Date of Patent: May 9, 2006
    Assignee: Neuren Pharmaceuticals Ltd.
    Inventors: Norman A. Abood, Margaret Anne Brimble
  • 2-amino-benzoxazinones for the treatment of viral infections
    Publication number: 20050032793
    Abstract: A class of compounds for the treatment of viral infections. Compounds of particular interest are defined by Formula I wherein R-R4 are as defined herein, or a pharmaceutically-acceptable salt thereof.
    Type: Application
    Filed: December 8, 2003
    Publication date: February 10, 2005
    Applicant: G.D. Searle & Co.
    Inventors: Norman Abood, Daniel Flynn, Daniel Becker, Brian Bax, Hui Li, Roger Nosal, Lori Schretzman, Clara Villamil
  • 2-Amino-benzoxazinones for the treatment of viral infections
    Patent number: 6683077
    Abstract: A class of compounds for the treatment of viral infections. Compounds of particular interest are defined by Formula I wherein R-R4 are as defined herein, or a pharmaceutically-acceptable salt thereof.
    Type: Grant
    Filed: January 4, 2002
    Date of Patent: January 27, 2004
    Assignee: G.D. Searle & Co.
    Inventors: Norman Abood, Daniel L. Flynn, Daniel P. Becker, Brian M. Bax, Hui Li, Roger A. Nosal, Lori A. Schretzman, Clara I. Villamil
  • GPE analogs and peptidominetics
    Publication number: 20030055004
    Abstract: This invention relates to analogs and peptidomimetics of glycyl-L-prolyl-L-glutamic acid (GPE). In particular, this invention relates to GPE analogs and peptidomimetics that are anti-apoptotic and anti-necrotic, to methods of making them, to pharmaceutical compositions containing them, and to their use.
    Type: Application
    Filed: May 24, 2002
    Publication date: March 20, 2003
    Inventors: Norman A. Abood, Margaret Anne Brimble
  • 2-Amino-benzoxazinones for the treatment of viral infections
    Publication number: 20030022895
    Abstract: A class of compounds for the treatment of viral infections.
    Type: Application
    Filed: January 4, 2002
    Publication date: January 30, 2003
    Applicant: G.D. Searle & Co.
    Inventors: Norman Abood, Daniel L. Flynn, Daniel P. Becker, Brian M. Bax, Hui Li, Roger A. Nosal, Lori A. Schretzman, Clara I. Villamil
  • 2-amino benzoxazinones for the treatment of viral infections
    Patent number: 6380189
    Abstract: A class of compounds for the treatment of viral infections. Compounds of particular interest are defined by Formula I wherein R-R4 are as defined herein, or a pharmaceutically-acceptable salt thereof.
    Type: Grant
    Filed: February 11, 2000
    Date of Patent: April 30, 2002
    Assignee: G.D. Searle & Co.
    Inventors: Norman Abood, Daniel L. Flynn, Daniel P. Becker, Brian M. Bax, Hui Li, Roger A. Nosal, Lori A. Schretzman, Clara I. Villamil
  • Synthesis of chiral N-protected-.alpha.-substituted-glycine free acids by zinc-mediated addition of organic halide to glycine cation equivalent
    Patent number: 5665598
    Abstract: A method is described for synthesis of N-Boc-L-propargylglycine, a key intermediate used in the preparation of high-potency, orally-active renin inhibitors. This method involves reaction of an organic halide with a glycine cation equivalent, such as methyl N-Boc-2-acetoxyglycine, in the presence of zinc dust to give Boc-protected amino acid derivatives in high yield. Typically useful organic halides are allylic, benzylic and propargylic halides. Resolution of methyl N-Boc-propargylglycine with .alpha.-chymotrypsin provides N-Boc-L-propargylglycine in high yield.
    Type: Grant
    Filed: January 29, 1996
    Date of Patent: September 9, 1997
    Assignee: G. D. Searle & Co.
    Inventors: Norman A. Abood, Roger A. Nosal
  • Phenyl amidine lactones useful as platelet aggregation inhibitors
    Patent number: 5612355
    Abstract: This invention relates to phenyl amidine alkanoic acids and lactones having the following formula ##STR1## or a pharmaceutically acceptable salt which are useful in the inhibition of platelet aggregation. This invention also relates to pharmaceutical compositions of such phenyl amidine derivatives.
    Type: Grant
    Filed: May 26, 1995
    Date of Patent: March 18, 1997
    Assignee: G. D. Searle & Co.
    Inventors: Norman A. Abood, Robert E. Manning, Masateru Miyano
  • Process for the preparation of amidino phenyl pyrrolidine beta-alanine urea analogs
    Patent number: 5610296
    Abstract: The invention herein is directed to a process for producing a lactam of the formula ##STR1## from a methionine analog of the formula ##STR2## by treating the methionine analog with trimethylsulfonium halide or trimethylsulfoxonium halide in the presence of a base in a suitable aprotic solvent.The invention herein is further directed to the preparation of amidinophenyl pyrrolidinyl .beta.-alanine urea analogs using such methionine and lactam compounds as intermediates, which .beta.-alanine urea analogs are useful as antithrombotics.
    Type: Grant
    Filed: December 5, 1994
    Date of Patent: March 11, 1997
    Assignee: G. D. Searle & Co.
    Inventors: Norman A. Abood, Daniel L. Flynn, Scott A. Laneman, Roger Nosal, Lori A. Schretzman
  • Process for the preparation of amidino phenyl pyrrolidine .beta.-alanine urea analogs
    Patent number: 5576447
    Abstract: The invention herein is directed to a process for producing a lactam of the formula ##STR1## from a methionine analog of the formula ##STR2## by treating the methionine analog with trimethylsulfonium halide or trimethylsulfoxonium halide in the presence of a base in a suitable aprotic solvent.The invention herein is further directed to the preparation of amidinophenyl pyrrolidinyl .beta.-alanine urea analogs using such methionine and lactam compounds as intermediates, which .beta.-alanine urea analogs are useful as antithrombotics.
    Type: Grant
    Filed: June 5, 1995
    Date of Patent: November 19, 1996
    Assignee: G. D. Searle & Co.
    Inventors: Norman A. Abood, Daniel L. Flynn, Scott A. Laneman, Roger Nosal, Lori A. Schretzman
  • Peptide mimetic compounds useful as platelet aggregation inhibitors
    Patent number: 5552431
    Abstract: This invention relates to compounds having the following formula ##STR1## or a pharmaceutically acceptable salt which are useful in the inhibition of platelet aggregation. This invention also relates to pharmaceutical compositions--of such phenyl amidines derivatives.
    Type: Grant
    Filed: March 24, 1995
    Date of Patent: September 3, 1996
    Assignee: G. D. Searle & Co.
    Inventors: Norman A. Abood, Robert B. Garland, Masateru Miyano
  • Synthesis of N-protected-.alpha.-substituted-glycine racemic esters by zinc-mediated addition of organic halide to glycine cation equivalent
    Patent number: 5508466
    Abstract: A method is described for synthesis of N-Boc-L-propargylglycine, a key intermediate used in the preparation of high-potency, orally-active renin inhibitors. This method involves reaction of an organic halide with a glycine cation equivalent, such as methyl N-Boc-2-acetoxyglycine, in the presence of zinc dust to give Boc-protected amino acid derivatives in high yield. Typically useful organic halides are allylic, benzylic and propargylic halides. Resolution of methyl N-Boc-propargylglycine with .alpha.-chymotrypsin provides N-Boc-L-propargylglycine in high yield.
    Type: Grant
    Filed: April 13, 1994
    Date of Patent: April 16, 1996
    Assignee: G.D. Searle & Co.
    Inventors: Norman A. Abood, Roger A. Nosal
  • Phenyl amidine alkanoic acids and lactones useful as platelet aggregation inhibitors
    Patent number: 5504106
    Abstract: This invention relates to phenyl amidine alkanoic acids and lactones having the following formula ##STR1## or a pharmaceutically acceptable salt which are useful in the inhibition of platelet aggregation. This invention also relates to pharmaceutical compositions of such phenyl amidine derivatives.
    Type: Grant
    Filed: July 21, 1994
    Date of Patent: April 2, 1996
    Assignee: G. D. Searle & Co.
    Inventors: Norman A. Abood, Robert E. Manning, Masateru Miyano
  • Process for the preparation of amidino phenyl pyrrolidine .beta.-alanine urea analogs
    Patent number: 5484946
    Abstract: The invention herein is directed to a process for producing a lactam of the formula ##STR1## from a methionine analog of the formula ##STR2## by treating the methionine analog with trimethylsulfonium halide or trimethylsulfoxonium halide in the presence of a base in a suitable aprotic solvent.The invention herein is further directed to the preparation of amidinophenyl pyrrolidinyl .beta.-alanine urea analogs using such methionine and lactam compounds as intermediates, which .beta.-alanine urea analogs are useful as antithrombotics.
    Type: Grant
    Filed: June 5, 1995
    Date of Patent: January 16, 1996
    Assignee: G. D. Searle & Co.
    Inventors: Norman A. Abood, Daniel L. Flynn, Scott A. Laneman, Roger Nosal, Lori A. Schretzman
  • Peptide mimetic compounds useful as platelet aggregation inhibitors
    Patent number: 5424334
    Abstract: This invention relates to compounds having the following formula ##STR1## or a pharmaceutically acceptable salt which are useful in the inhibition of platelet aggregation. This invention also relates to pharmaceutical compositions--of such phenyl amidines derivatives.
    Type: Grant
    Filed: December 19, 1991
    Date of Patent: June 13, 1995
    Assignee: G. D. Searle & Co.
    Inventors: Norman A. Abood, Robert B. Garland, Masateru Miyano