Patents by Inventor Norman Anthony Abood

Norman Anthony Abood has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Double prodrugs of potent GP IIb/IIIa antagonists
    Patent number: 6025358
    Abstract: The present invention relates to double prodrugs of pharmacologically active glycoprotein IIb/IIIa antagonists of the formula ##STR1## wherein R.sub.1 is selected from the group consisting of lower alkyl of about 2 to about 8 carbon atoms, cycloalkyl, and aralkyl; R is selected from the group consisting of alkoxy, ##STR2## wherein R.sup.50 is H or alkyl; and ##STR3## wherein R.sup.50 is H or alkyl; and pharmaceutically acceptable salts thereof.
    Type: Grant
    Filed: May 19, 1999
    Date of Patent: February 15, 2000
    Assignee: G. D. Searle & Co.
    Inventors: Norman Anthony Abood, Michael J. Bennett, Lori A. Schretzman
  • 2-amino-benzoxazinones for the treatment of viral infections
    Patent number: 5985872
    Abstract: A class of compounds for the treatment of viral infections. Compounds of particular interest are defined by Formula II ##STR1## wherein R.sup.28 is selected from (a) amino substituted with one or two radicals selected from alkyl, aralkyl, heterocycoalkyl, heterocyclo, and aryl, and (b) amino acid residues and derivatives thereof; wherein R.sup.29 is selected from hydrido, alkyl, halo, ##STR2## wherein R.sup.30 is selected from alkyl, alkoxy, alkylamino, carboxyalkyl, alkoxyalkyl, alkylaminoalkyl, cycloalkyl, heterocyclo, heterocycloalkyl, heterocycloalkoxy, alkylaminoalkoxy, alkylaminoalkylamino, heterocycloalkylamino, and N-aralkylamino; wherein R.sup.31 is alkyl; wherein R.sup.32 is alkyl and aryl; or a pharmaceutically-acceptable salt thereof.
    Type: Grant
    Filed: May 24, 1995
    Date of Patent: November 16, 1999
    Assignee: G.D. Searle & Co.
    Inventors: Norman Anthony Abood, Daniel L. Flynn, Daniel P. Becker, Brian M. Bax, Hui Li, Roger A. Nosal, Lori A Schretzman, Clara I Villamil
  • Platelet aggregation inhibitors containing C-terminal aminergic side chain amino acid residues
    Patent number: 5811398
    Abstract: This invention relates to compounds having the following formula ##STR1## or pharmaceutically acceptable salt thereof which are useful in the inhibition of platelet aggregation, to pharmaceutical compositions containing such compounds, and to a method of inhibiting platelet aggregation in mammals by administering such compounds and compositions.
    Type: Grant
    Filed: April 11, 1995
    Date of Patent: September 22, 1998
    Assignee: G. D. Searle & Co.
    Inventors: Norman Anthony Abood, Philippe Roger Bovy, Daniel Lee Flynn, Joseph Gerace Rico, Thomas Edward Rogers
  • Platelet aggregation inhibitors
    Patent number: 5721366
    Abstract: This invention relates to compounds having the following formula ##STR1## or a pharmaceutically acceptable salt thereof which are useful in the inhibition of platelet aggregation, to pharmaceutical compositions of such phenylamidines derivatives, and to a method of inhibiting platelet aggregation in mammals by administering such compounds and compositions.
    Type: Grant
    Filed: May 23, 1995
    Date of Patent: February 24, 1998
    Assignee: G. D. Searle & Co
    Inventors: Norman Anthony Abood, Daniel Lee Flynn, Robert Bruce Garland, Lori Ann Schretzman, Kenneth Williams, Jeffery Alan Zablocki, Susan Landis Hockerman
  • Intermediates for amidino phenyl pyrrolidine .beta.-alanine urea analogs
    Patent number: 5659063
    Abstract: The invention herein is directed to a process for producing a lactam of the formula ##STR1## from a methionine analog of the formula ##STR2## by treating the methionine analog with trimethylsulfonium halide or trimethylsulfoxonium halide in the presence of a base in a suitable aprotic solvent.The invention herein is further directed to the preparation of amidinophenyl pyrrolidinyl .beta.-alanine urea analogs using such methionine and lactam compounds as intermediates, which .beta.-alanine urea analogs are useful as antithrombotics.
    Type: Grant
    Filed: June 6, 1995
    Date of Patent: August 19, 1997
    Assignee: G. D. Searle & Co.
    Inventors: Norman Anthony Abood, Daniel Lee Flynn, Scott Anthony Laneman, Roger Nosal, Lori Ann Schretzman
  • Phenyl amidine alkanoic acids useful as platelet aggregation inhibitors
    Patent number: 5646183
    Abstract: This invention relates to phenyl amidine alkanoic acids and lactones having the following formula ##STR1## or a pharmaceutically acceptable salt which are useful in the inhibition of platelet aggregation. This invention also relates to pharmaceutical compositions of such phenyl amidine derivatives.
    Type: Grant
    Filed: May 25, 1995
    Date of Patent: July 8, 1997
    Assignee: G. D. Searle & Co.
    Inventors: Norman Anthony Abood, Robert Everett Manning, Masateru Miyano