Patents by Inventor Norman Dovichi

Norman Dovichi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20190004010
    Abstract: The invention provides a capillary isoelectric focusing (cIEF) system based on a sandwich injection method for automated chemical mobilization. This system was coupled with an electrokinetically pumped nanoelectrospray interface to a mass spectrometer. The nanoelectrospray emitter employed an acidic sheath electrolyte. To realize automated focusing and mobilization, a plug of ammonium hydroxide was first injected into the capillary, followed by a section of mixed sample and ampholyte. As focusing progressed, the NH3H2O section was titrated to lower pH buffer by the acidic sheath buffer. Chemical mobilization started automatically once the ammonium hydroxide was consumed by the acidic sheath flow electrolyte.
    Type: Application
    Filed: September 22, 2017
    Publication date: January 3, 2019
    Applicant: UNIVERSITY OF NOTRE DAME DU LAC
    Inventors: Norman DOVICHI, Guijie ZHU, Liangliang SUN
  • Publication number: 20180363054
    Abstract: Current procedures for the analysis of sexual assault kits are labor intensive, time consuming and deliver a success rate lower than 40%. This has resulted in rape kit backlogs of thousands. The primary challenge crime laboratories face in analyzing these cases is the separation of purified male DNA from the mixture of primarily female DNA from gynecological swabs. Effective elution of the sample from the swab and efficient separation of intact sperm cells from epithelial and other cellular debris, allow for a successful PCR amplification and short tandem repeat (STR) DNA analysis for perpetrator identification. The disclosure provides an effective and economically accessible technology for the separation of male and female cells and DNA, for example, from a gynecological swab by capillary zone electrophoresis (CZE).
    Type: Application
    Filed: June 20, 2018
    Publication date: December 20, 2018
    Applicant: University of Notre Dame du Lac
    Inventors: Sarah LUM, Norman DOVICHI, Bonnie JASKOWSKI HUGE, Carlos Gusti GARTNER
  • Publication number: 20180258461
    Abstract: Capillary electrophoresis fractionation of an environmental microbiota segregates high abundance microbes from lower abundance species, and results in a three-fold increase in the number of 16s rRNA OTUs that map to known species. However, most of the bacteria are found in a few wells, although reasonably large numbers of OTUs were found in over half the wells.
    Type: Application
    Filed: March 7, 2018
    Publication date: September 13, 2018
    Applicant: University of Notre Dame du Lac
    Inventors: Norman Dovichi, Bonnie Jaskowski Huge, Matthew Champion
  • Publication number: 20170363576
    Abstract: The invention provides a novel method of coating the inside of a capillary with a polymeric material. The method can include introducing a catalyst-free solution of a monomer and initiator, wherein the monomer is present in about 1-10% (w/v) and the initiator is present in 0.1-1% (w/v), into a capillary and thermally initiating polymerization of the monomer thereby providing a capillary comprising an internal polymeric coating for separating, identifying, and quantifying components of an analyte.
    Type: Application
    Filed: June 20, 2016
    Publication date: December 21, 2017
    Applicant: University of Notre Dame du Lac
    Inventors: Norman DOVICHI, Guijie ZHU, Liangliang SUN
  • Patent number: 9465014
    Abstract: The invention provides a sheath-flow interface for producing electrospray from a capillary. The electrospray generated by the interface can be used as the source of ions for mass spectrometry. Electrokinetic flow in the interface can move a sheath liquid past the end of a capillary so as to mix with an analyte effluent discharged from the capillary. The sheath liquid and analyte mixture can be directed to an electrospray emitter to generate an electrospray.
    Type: Grant
    Filed: April 5, 2015
    Date of Patent: October 11, 2016
    Assignee: University of Notre Dame du Lac
    Inventors: Norman Dovichi, Liangliang Sun, Guijie Zhu
  • Patent number: 9362102
    Abstract: The invention provides a sheath-flow interface for producing electrospray from a capillary. The electrospray generated by the interface can be used as the source of ions for mass spectrometry. Electrokinetic flow in the interface can move a sheath liquid past the end of a capillary so as to mix with an analyte effluent discharged from the capillary. The sheath liquid and analyte mixture can be directed to an electrospray emitter to generate an electrospray.
    Type: Grant
    Filed: July 7, 2015
    Date of Patent: June 7, 2016
    Assignee: University of Notre Dame du Lac
    Inventors: Norman Dovichi, Liangliang Sun, Guijie Zhu
  • Patent number: 9234880
    Abstract: A sheath-flow interface for producing electrospray from a capillary is provided. The electrospray generated by the interface can be used as the source of ions for mass spectrometry. In the interface, electrokinetic flow moves a sheath liquid past the end of a capillary so as to mix with an analyte effluent discharged from the capillary. The mixture of sheath liquid and analyte is directed to an electrospray emitter in order to generate an electrospray.
    Type: Grant
    Filed: June 4, 2012
    Date of Patent: January 12, 2016
    Assignee: University of Washington through its Center for Commercialization
    Inventors: Norman Dovichi, Roza Wojcik
  • Publication number: 20150311056
    Abstract: The invention provides a sheath-flow interface for producing electrospray from a capillary. The electrospray generated by the interface can be used as the source of ions for mass spectrometry. Electrokinetic flow in the interface can move a sheath liquid past the end of a capillary so as to mix with an analyte effluent discharged from the capillary. The sheath liquid and analyte mixture can be directed to an electrospray emitter to generate an electrospray.
    Type: Application
    Filed: July 7, 2015
    Publication date: October 29, 2015
    Applicant: University of Notre Dame de Lac
    Inventors: Norman Dovichi, Liangliang Sun, Guijie Zhu
  • Patent number: 9159537
    Abstract: Described herein is a method and system for on-line coupling of capillary isoelectric focusing (cIEF) to high-resolution mass spectrometry in which a sheath flow buffer comprising polar organic solvent and organic acid is used as both an immobilization solution for (cIEF) and an ionization solution for electrospray ionization (ESI).
    Type: Grant
    Filed: May 2, 2013
    Date of Patent: October 13, 2015
    Assignees: University of Notre Dame du Lac, Medimmune, LLC
    Inventors: James McGivney, Guijie Zhu, Norman Dovichi
  • Publication number: 20150233877
    Abstract: The invention provides a sheath-flow interface for producing electrospray from a capillary. The electrospray generated by the interface can be used as the source of ions for mass spectrometry. Electrokinetic flow in the interface can move a sheath liquid past the end of a capillary so as to mix with an analyte effluent discharged from the capillary. The sheath liquid and analyte mixture can be directed to an electrospray emitter to generate an electrospray.
    Type: Application
    Filed: April 5, 2015
    Publication date: August 20, 2015
    Applicant: UNIVERSITY OF NOTRE DAME DU LAC
    Inventors: Norman Dovichi, Liangliang Sun, Guijie Zhu
  • Publication number: 20150162177
    Abstract: Described herein is a method and system for on-line coupling of capillary isoelectric focusing (cIEF) to high-resolution mass spectrometry in which a sheath flow buffer comprising polar organic solvent and organic acid is used as both an immobilization solution for (cIEF) and an ionization solution for electrospray ionization (ESI).
    Type: Application
    Filed: May 2, 2013
    Publication date: June 11, 2015
    Inventors: James McGivney, Guijie Zhu, Norman Dovichi
  • Publication number: 20130140180
    Abstract: A sheath-flow interface for producing electrospray from a capillary is provided. The electrospray generated by the interface can be used as the source of ions for mass spectrometry. In the interface, electrokinetic flow moves a sheath liquid past the end of a capillary so as to mix with an analyte effluent discharged from the capillary. The mixture of sheath liquid and analyte is directed to an electrospray emitter in order to generate an electrospray.
    Type: Application
    Filed: June 4, 2012
    Publication date: June 6, 2013
    Applicant: University of Washington through its Center for Commercialization
    Inventors: Norman Dovichi, Roza Wojcik