Patents by Inventor Norman Earle Hughes

Norman Earle Hughes has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • SUBSTITUTED PYRAZOLE ANALOGS As RAR ANTAGONISTS
    Publication number: 20140275049
    Abstract: The present invention provides compounds of Formula I or a pharmaceutical salt thereof; methods of treating osteoarthritis and the pain associated with osteoarthritis using the compounds; and processes for preparing the compounds.
    Type: Application
    Filed: October 19, 2012
    Publication date: September 18, 2014
    Inventors: Thomas John Bleisch, David Andrew Coates, Norman Earle Hughes, Scott Alan Jones, Bryan Hurst Norman
  • Imidazole derivatives useful for the treatment of arthritis
    Patent number: 8648200
    Abstract: The present invention provides compounds of the formula below: where A, X and R1-R6 are as described herein, a pharmaceutical salt thereof, and a pharmaceutical composition containing this compound; methods of treating pain associated with osteoarthritis using one of the compounds or a pharmaceutically acceptable salt thereof, and processes for preparing the compounds.
    Type: Grant
    Filed: May 10, 2012
    Date of Patent: February 11, 2014
    Assignee: Eli Lilly and Company
    Inventors: Norman Earle Hughes, Bryan Hurst Norman, Timothy Andrew Woods
  • Novel Imidazole Derivatives Useful for the Treatment of Arthritis
    Publication number: 20120302608
    Abstract: The present invention provides compounds of the formula below: where A, X and R1-R6 are as described herein, a pharmaceutical salt thereof, and a pharmaceutical composition containing this compound; methods of treating pain associated with osteoarthritis using one of the compounds or a pharmaceutically acceptable salt thereof, and processes for preparing the compounds.
    Type: Application
    Filed: May 10, 2012
    Publication date: November 29, 2012
    Applicant: ELI LILLY AND COMPANY
    Inventors: Norman Earle Hughes, Bryan Hurst Norman, Timothy Andrew Woods
  • Pentalfluoroalkanesulfinyl naphthalenes and related estrogen receptor modulators
    Patent number: 7462647
    Abstract: The present invention provides a compound of the formula (I) wherein R is —H, or —C1-C4 alkyl; R1 is —H, —OH, —O(C1-C4 alkyl), —SO2(C1-C4 alkyl), or halo; X is —O—, —CH2—, or —C(O)—; X1 is —O— or —NR2—; R2 is —H or —CH3; Y is —S—, —CH2CH2—, or —HC?CH—; m is 0, 1, 2, or 3; and n is 0 or 1; or a pharmaceutically acceptable salt thereof; pharmaceutical compositions thereof; and methods for inhibiting a disease associated with an aberrant physiological response to endogenous estrogen.
    Type: Grant
    Filed: May 27, 2004
    Date of Patent: December 9, 2008
    Assignee: Eli Lilly and Company
    Inventors: Jeffrey Alan Dodge, Norman Earle Hughes