Patents by Inventor Norman F. Sheppard

Norman F. Sheppard has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20200249150
    Abstract: A sensor and analyzer for measuring an analyte in a liquid sample are disclosed. The sensor includes a substrate with a reservoir disposed therein. The reservoir may include a top surface and a bottom surface, at least one transparent portion forming at least a part of the bottom surface of the reservoir, and a reflector disposed on the upper surface of the reservoir at a location opposite the at least one transparent portion. The analyzer may include a support surface, an aperture extending through the support surface, a light source disposed below the support surface and oriented so that at least a portion of the light emitted from the light source passes through the aperture, and a detector configured to measure an intensity of light received at the detector.
    Type: Application
    Filed: November 11, 2019
    Publication date: August 6, 2020
    Inventors: Norman F. Sheppard, JR., Gary Conrad Jensen
  • Patent number: 10473582
    Abstract: A sensor and analyzer for measuring an analyte in a liquid sample are disclosed. The sensor includes a substrate with a reservoir disposed therein. The reservoir may include a top surface and a bottom surface, at least one transparent portion forming at least a part of the bottom surface of the reservoir, and a reflector disposed on the upper surface of the reservoir at a location opposite the at least one transparent portion. The analyzer may include a support surface, an aperture extending through the support surface, a light source disposed below the support surface and oriented so that at least a portion of the light emitted from the light source passes through the aperture, and a detector configured to measure an intensity of light received at the detector.
    Type: Grant
    Filed: September 11, 2017
    Date of Patent: November 12, 2019
    Assignee: Magellan Diagnostics, Inc.
    Inventors: Norman F. Sheppard, Jr., Gary Conrad Jensen
  • Publication number: 20180059010
    Abstract: A sensor and analyzer for measuring an analyte in a liquid sample are disclosed. The sensor includes a substrate with a reservoir disposed therein. The reservoir may include a top surface and a bottom surface, at least one transparent portion forming at least a part of the bottom surface of the reservoir, and a reflector disposed on the upper surface of the reservoir at a location opposite the at least one transparent portion. The analyzer may include a support surface, an aperture extending through the support surface, a light source disposed below the support surface and oriented so that at least a portion of the light emitted from the light source passes through the aperture, and a detector configured to measure an intensity of light received at the detector.
    Type: Application
    Filed: September 11, 2017
    Publication date: March 1, 2018
    Inventors: Norman F. Sheppard, JR., Gary Conrad Jensen
  • Patent number: 9796583
    Abstract: Compression cold welding methods, joint structures, and hermetically sealed containment devices are provided. The method includes providing a first substrate having at least one first joint structure which comprises a first joining surface, which surface comprises a first metal; providing a second substrate having at least one second joint structure which comprises a second joining surface, which surface comprises a second metal; and compressing together the at least one first joint structure and the at least one second joint structure to locally deform and shear the joining surfaces at one or more interfaces in an amount effective to form a metal-to-metal bond between the first metal and second metal of the joining surfaces. Overlaps at the joining surfaces are effective to displace surface contaminants and facilitate intimate contact between the joining surfaces without heat input. Hermetically sealed devices can contain drug formulations, biosensors, or MEMS devices.
    Type: Grant
    Filed: June 4, 2012
    Date of Patent: October 24, 2017
    Assignee: Microchips Biotech, Inc.
    Inventors: Jonathan R. Coppeta, Kurt Shelton, Norman F. Sheppard, Jr., Douglas Snell, Catherine M. B. Santini
  • Patent number: 9759651
    Abstract: A sensor and analyzer for measuring an analyte in a liquid sample are disclosed. The sensor includes a substrate with a reservoir disposed therein. The reservoir may include a top surface and a bottom surface, at least one transparent portion forming at least a part of the bottom surface of the reservoir, and a reflector disposed on the upper surface of the reservoir at a location opposite the at least one transparent portion. The analyzer may include a support surface, an aperture extending through the support surface, a light source disposed below the support surface and oriented so that at least a portion of the light emitted from the light source passes through the aperture, and a detector configured to measure an intensity of light received at the detector.
    Type: Grant
    Filed: December 22, 2015
    Date of Patent: September 12, 2017
    Assignee: Magellan Diagnostics, Inc.
    Inventors: Norman F. Sheppard, Jr., Gary Conrad Jensen
  • Publication number: 20170192021
    Abstract: A sensor and method for measuring bilirubin in a liquid sample are disclosed. The sensor comprises a substrate comprising a reservoir disposed within the substrate, the reservoir having a top surface and a bottom surface; a filter; at least one transparent portion, the transparent portion forming at least a part of the bottom surface of the reservoir, and a reflector comprising at least a portion of the reservoir. The method for measuring bilirubin in a liquid sample comprises inserting a sensor into an analyzer; introducing the liquid sample to the sensor; filtering the liquid sample such that the sample flows into a reservoir in the sensor; illuminating the liquid sample in the sensor using a light source in the analyzer; measuring a reflectance of the liquid sample at one or more wavelengths using a detector in the analyzer; and computing a measurement of bilirubin using the measured reflectances.
    Type: Application
    Filed: December 29, 2016
    Publication date: July 6, 2017
    Inventors: Norman F. Sheppard, JR., Gary Conrad Jensen, Roland Lawrence Guilmet, Peter Michael Magnin
  • Publication number: 20160178573
    Abstract: A sensor and analyzer for measuring an analyte in a liquid sample are disclosed. The sensor includes a substrate with a reservoir disposed therein. The reservoir may include a top surface and a bottom surface, at least one transparent portion forming at least a part of the bottom surface of the reservoir, and a reflector disposed on the upper surface of the reservoir at a location opposite the at least one transparent portion. The analyzer may include a support surface, an aperture extending through the support surface, a light source disposed below the support surface and oriented so that at least a portion of the light emitted from the light source passes through the aperture, and a detector configured to measure an intensity of light received at the detector.
    Type: Application
    Filed: December 22, 2015
    Publication date: June 23, 2016
    Inventors: Norman F. Sheppard, JR., Gary Conrad Jensen
  • Patent number: 8649840
    Abstract: Electrochemical sensor devices are provided, in various amperometric, potentiometric, and conductometric sensor device configurations. An amperometric sensor device may include a structural body which has at least one reservoir that has at least one opening; a working electrode located within the reservoir; analyte sensor chemistry located within the reservoir and deposited on at least the working electrode; an auxiliary electrode located outside of the reservoir; a reference electrode; at least one reservoir cap closing the opening to isolate the working electrode and analyte sensor chemistry within the reservoir and to prevent an analyte outside of the reservoir from contacting the analyte sensor chemistry; and means for rupturing or displacing the reservoir cap to permit the analyte from outside of the reservoir to contact the analyte sensor chemistry.
    Type: Grant
    Filed: June 6, 2008
    Date of Patent: February 11, 2014
    Assignee: Microchips, Inc.
    Inventors: Norman F. Sheppard, Jr., John T. Santini, Jr.
  • Patent number: 8604810
    Abstract: Arrays of biosensors are provided along with methods for operating the arrays of biosensors. The array of biosensors may include a first reference electrode that is connected to an input of a first control amplifier; a first working electrode and a second working electrode in proximity with the first reference electrode; and a counter electrode that is connected to at least an output of the first control amplifier, where the first control amplifier is operative with the counter electrode to maintain a first specified voltage between the first working electrode and the first reference electrode, and between the second working electrode and the first reference electrode.
    Type: Grant
    Filed: October 15, 2010
    Date of Patent: December 10, 2013
    Assignee: MicroCHIPS, Inc.
    Inventor: Norman F. Sheppard, Jr.
  • Publication number: 20130211219
    Abstract: Sensor devices and methods are provided for detecting the presence or concentration of an analyte in fluid. The device has a reservoir; a working electrode located within the reservoir, a catalyst covering at least part of the working electrode; an oxygen-generating auxiliary electrode in the reservoir; and a reservoir cap to isolate the working and auxiliary electrodes within the reservoir. The device further includes means for selectively rupturing the cap to permit analyte from outside the reservoir to contact the catalyst. The methods may include in vivo glucose monitoring and may include implanting the device in a patient; disintegrating a reservoir cap to permit glucose to enter the reservoir; generating oxygen using the oxygen-generating auxiliary electrode; and using a working electrode to oxidize hydrogen peroxide produced by the reaction of the oxygen with glucose in the presence of glucose oxidase, and thereby detecting endogenous glucose in the patient.
    Type: Application
    Filed: August 12, 2011
    Publication date: August 15, 2013
    Applicant: Micro CHIPS ,Inc.
    Inventors: Jonathan R. Coppeta, Robert Farra, Kenneth L. Hilts, Norman F. Sheppard, JR.
  • Patent number: 8442611
    Abstract: A medical device is provided which may include a reservoir which has an opening and contains a sensor; a reservoir cap closing off the opening to isolate the sensor from an environmental component outside the reservoirs, the reservoir cap being impermeable to the environmental component and adapted to selectively undergo a phase change to disintegrate the reservoir cap and thereby expose the sensor to the environmental component. A method of use may include (i) selectively disintegrating a reservoir cap to expose a sensor which is disposed inside a reservoir of a device implanted in a patient, the disintegrating comprising inducing a phase change in the reservoir cap; and (ii) using the sensor to generate an output signal, wherein the output signal is recorded and stored in a writeable computer memory chips, directed to a microprocessor for immediate analysis and processing, or sent to a remote location away from the device.
    Type: Grant
    Filed: January 15, 2010
    Date of Patent: May 14, 2013
    Assignee: MicroCHIPS, Inc.
    Inventors: John T. Santini, Jr., Norman F. Sheppard, Jr., Chung Chang Young, Robert S. Langer
  • Patent number: 8403915
    Abstract: Devices, such as medical devices, are provided which include a body portion having at least one reservoir which has two or more openings, the two or more openings being defined in part by a reservoir cap support; reservoir contents, such as a drug formulation or sensor, disposed inside the reservoir; and a reservoir cap which closes off the two or more reservoir openings. The reservoir cap, which can be ruptured, controls release or exposure of the reservoir contents. In one embodiment, the device is an implantable medical device and provides for the controlled release of drug or exposure of a sensor.
    Type: Grant
    Filed: October 19, 2009
    Date of Patent: March 26, 2013
    Assignee: MicroCHIPS, Inc.
    Inventors: John T. Santini, Jr., Zouhair Sbiaa, Jonathan R. Coppeta, Scott A. Uhland, Norman F. Sheppard, Jr.
  • Patent number: 8403907
    Abstract: A method is provided for monitoring the status of a medical device implanted in a patient. The method includes the steps of implanting in a patient a medical device which comprises (i) a substrate in which two or more reservoirs are located, with each covered by a reservoir cap, (ii) a drug or sensor located in the reservoir, (iii) a power source and actuation electronics for disintegrating or permeabilizing the reservoir cap, and (iv) a telemetry system; and then using said telemetry system to wirelessly transmit to a remote controller data about the condition of the power source and/or data about which reservoirs have been or have yet to be activated to release the drug therefrom or to expose the sensor therein.
    Type: Grant
    Filed: October 29, 2007
    Date of Patent: March 26, 2013
    Assignee: MicroCHIPS, Inc.
    Inventors: Norman F. Sheppard, Jr., John T. Santini, Jr., Michael J. Cima, Robert S. Langer, Dennis Ausiello
  • Patent number: 8308707
    Abstract: Methods and systems are provided for delivering drug to the eye. The method and system may include implanting into the eye a device which comprises two or more discrete reservoirs, each reservoir containing a drug; and directing focused light to the implanted device to open a first one of the reservoirs and thereby permit the drug to diffuse from the first reservoir to the patient's eye.
    Type: Grant
    Filed: January 24, 2011
    Date of Patent: November 13, 2012
    Assignee: MicroCHIPS, Inc.
    Inventors: John T. Santini, Jr., Michael J. Cima, Robert S. Langer, Dennis Ausiello, Norman F. Sheppard, Jr., Stephen J. Herman
  • Publication number: 20120241216
    Abstract: Compression cold welding methods, joint structures, and hermetically sealed containment devices are provided. The method includes providing a first substrate having at least one first joint structure which comprises a first joining surface, which surface comprises a first metal; providing a second substrate having at least one second joint structure which comprises a second joining surface, which surface comprises a second metal; and compressing together the at least one first joint structure and the at least one second joint structure to locally deform and shear the joining surfaces at one or more interfaces in an amount effective to form a metal-to-metal bond between the first metal and second metal of the joining surfaces. Overlaps at the joining surfaces are effective to displace surface contaminants and facilitate intimate contact between the joining surfaces without heat input. Hermetically sealed devices can contain drug formulations, biosensors, or MEMS devices.
    Type: Application
    Filed: June 4, 2012
    Publication date: September 27, 2012
    Applicant: MicroCHIPS, Inc.
    Inventors: Jonathan R. Coppeta, Kurt Shelton, Norman F. Sheppard, JR., Douglas Snell, Catherine M.B. Santini
  • Patent number: 8211092
    Abstract: Devices and methods are provided for the controlled release or exposure of reservoir contents. The device includes a substrate, a plurality of reservoirs in the substrate, reservoir contents disposed in the reservoirs, discrete reservoir caps covering each reservoir to seal the reservoir contents in the reservoirs, and control circuitry for selectively disintegrating the reservoir caps to release or expose the reservoir contents in vivo. At least one of the reservoir caps comprises a first electrically conductive layer coated with one or more protective layers. In one embodiment, the control circuitry comprises an electrical input lead and an electrical output lead connected to and directly contacting each of said reservoir caps and a source of electric power for applying an electrical current through each reservoir cap in an amount effective to rupture each of the reservoir caps.
    Type: Grant
    Filed: October 1, 2008
    Date of Patent: July 3, 2012
    Assignee: MicroCHIPS, Inc.
    Inventors: Scott A. Uhland, Benjamin F. Polito, John M. Maloney, Norman F. Sheppard, Jr., Stephen J. Herman, Barry M. Yomtov
  • Patent number: 8191756
    Abstract: Compression cold welding methods, joint structures, and hermetically sealed containment devices are provided. The method includes providing a first substrate having at least one first joint structure which comprises a first joining surface, which surface comprises a first metal; providing a second substrate having at least one second joint structure which comprises a second joining surface, which surface comprises a second metal; and compressing together the at least one first joint structure and the at least one second joint structure to locally deform and shear the joining surfaces at one or more interfaces in an amount effective to form a metal-to-metal bond between the first metal and second metal of the joining surfaces. Overlaps at the joining surfaces are effective to displace surface contaminants and facilitate intimate contact between the joining surfaces without heat input. Hermetically sealed devices can contain drug formulations, biosensors, or MEMS devices.
    Type: Grant
    Filed: November 4, 2005
    Date of Patent: June 5, 2012
    Assignee: MicroCHIPS, Inc.
    Inventors: Jonathan R. Coppeta, Kurt Shelton, Norman F. Sheppard, Jr., Douglas Snell, Catherine M. B. Santini
  • Patent number: 7985386
    Abstract: An implantable medical device is provided for use with an external detector to detect an analyte in vivo. In one embodiment, the device consisting essentially of a substrate; a plurality of discrete reservoirs located in the substrate, each reservoir having at least one opening; a reacting component contained in each reservoir; and at least one non-degradable barrier layer covering each reservoir opening, the barrier layer being permeable to an analyte to be detected, wherein the reacting component remains inside the reservoirs and can react with the analyte to be detected, and wherein the device is adapted for implantation into the body of a patient.
    Type: Grant
    Filed: September 29, 2008
    Date of Patent: July 26, 2011
    Assignee: MicroCHIPS, Inc.
    Inventors: John T. Santini, Jr., Norman F. Sheppard, Jr.
  • Publication number: 20110172587
    Abstract: Methods and systems are provided for delivering drug to the eye. The method and system may include implanting into the eye a device which comprises two or more discrete reservoirs, each reservoir containing a drug; and directing focused light to the implanted device to open a first one of the reservoirs and thereby permit the drug to diffuse from the first reservoir to the patient's eye.
    Type: Application
    Filed: January 24, 2011
    Publication date: July 14, 2011
    Applicant: MICROCHIPS, INC.
    Inventors: John T. Santini, JR., Michael J. Cima, Robert S. Langer, Dennis Ausiello, Norman F. Sheppard, JR., Stephen J. Herman
  • Publication number: 20110089957
    Abstract: Arrays of biosensors are provided along with methods for operating the arrays of biosensors. The array of biosensors may include a first reference electrode that is connected to an input of a first control amplifier; a first working electrode and a second working electrode in proximity with the first reference electrode; and a counter electrode that is connected to at least an output of the first control amplifier, where the first control amplifier is operative with the counter electrode to maintain a first specified voltage between the first working electrode and the first reference electrode, and between the second working electrode and the first reference electrode.
    Type: Application
    Filed: October 15, 2010
    Publication date: April 21, 2011
    Applicant: MICROCHIPS, INC.
    Inventor: Norman F. Sheppard, JR.