Abstract: The systems and methods include generating polarization-switched (PS) detector and reference signals using a polarization switch controlled by a digital control signal generated by digital input/output card. A gain adjustment is performed on the PS detector and reference signals to define gain-adjusted detector and reference signals. The digital control signal is used to synchronize the gain-adjusted PS detector and reference signals to define gain-adjusted synchronized PS detector and reference signals each having respective steady-state portions. The steady state portions are used to define a measurement signal. The measurement signal is then used to calculate a stress-based characteristic of the sample being measured. The sample can be moved continuously or discretely through different measurement positions, which are synchronized with the operation of the polarization switch using the digital control signal.

Abstract: The systems and methods include generating polarization-switched (PS) detector and reference signals using a polarization switch controlled by a digital control signal generated by digital input/output card. A gain adjustment is performed on the PS detector and reference signals to define gain-adjusted detector and reference signals. The digital control signal is used to synchronize the gain-adjusted PS detector and reference signals to define gain-adjusted synchronized PS detector and reference signals each having respective steady-state portions. The steady state portions are used to define a measurement signal. The measurement signal is then used to calculate a stress-based characteristic of the sample being measured. The sample can be moved continuously or discretely through different measurement positions, which are synchronized with the operation of the polarization switch using the digital control signal.

Abstract: According to some embodiments a method of measuring the refractive index profile of a consolidated glass body having a cylindrical surface comprises the steps of: (a) forming an image of a slit behind the glass body; (b) optionally pre-scanning the cylindrical surface of the test glass body or a reference glass body and analyzing the data within a fixed window to determine the likely location of the zero-order, un-diffracted beam while ignoring other diffracted beams; (c) optionally adjusting the optical power to improve the intensity of the data within the fixed window in order to improve the analysis; (d) predicting the trajectory of the zero-order beam through the preform based on the sampling location xi (incidence position) of the light impinging on the cylindrical surface and the location at which the zero-order beam impinges on the detector; (e) measuring the cylindrical surface of a glass body while using the estimated location of the zero-order beam and adjusted optical power to set the center of a f

Abstract: Methods for detection of particulate on thin, flexible substrates wherein the substrate is positioned in a bend comprising an apex line. The apex line is illuminated by grazing angle illumination, and light from the illumination scattered by the particulate is captured by a detection apparatus.

Abstract: According to some embodiments a method of measuring the refractive index profile of a consolidated glass body having a cylindrical surface comprises the steps of: (a) forming an image of a slit behind the glass body, (b) optionally pre-scanning the cylindrical surface of the test glass body or a reference glass body and analyzing the data within a fixed window to determine the likely location of the zero-order, un-diffracted beam while ignoring other diffracted beams; (c) optionally adjusting the optical power to improve the intensity of the data within the fixed window in order to improve the analysis; (d) predicting the trajectory of the zero-order beam through the preform based on the sampling location xi (incidence position) of the light impinging on the cylindrical surface and the location at which the zero-order beam impinges on the detector; (e) measuring the cylindrical surface of a glass body while using the estimated location of the zero-order beam and adjusted optical power to set the center of a f

Abstract: Methods for detection of particulate on thin, flexible substrates wherein the substrate is positioned in a bend comprising an apex line. The apex line is illuminated by grazing angle illumination, and light from the illumination scattered by the particulate is captured by a detection apparatus.

Abstract: Systems and methods for measuring a profile of a glass sample (300) are disclosed. The method includes scanning a polarization-switched light beam (112PS) through the glass sample and a reference block (320) for different depths into the glass sample to define a transmitted polarization-switched light beam. The method also includes measuring an amount of power in the polarization-switched light beam to form a polarization-switched reference signal (SR), and detecting the transmitted polarization-switched light beam to form a polarization-switched detector signal (SD). The method further includes dividing the polarization-switched detector signal by the polarization-switched reference signal to define a normalized polarization-switched detector signal (SN). Processing the normalized polarization-switched detector signal determines the profile characteristic.

Abstract: Disclosed are compositions and methods for using label free optical biosensors for performing cell assays. In certain embodiments the assays can be performed in high throughput methods and can be multiplexed.

Abstract: Systems and methods for measuring a profile of a glass sample (300) are disclosed. The method includes scanning a polarization-switched light beam (112PS) through the glass sample and a reference block (320) for different depths into the glass sample to define a transmitted polarization-switched light beam. The method also includes measuring an amount of power in the polarization-switched light beam to form a polarization-switched reference signal (SR), and detecting the transmitted polarization-switched light beam to form a polarization-switched detector signal (SD). The method further includes dividing the polarization-switched detector signal by the polarization-switched reference signal to define a normalized polarization-switched detector signal (SN). Processing the normalized polarization-switched detector signal determines the profile characteristic.

Abstract: Disclosed are compositions and methods for using label free optical biosensors for performing cell assays. In certain embodiments the assays can be performed in high throughput methods and can be multiplexed.

Abstract: A surface plasmon resonance sensor system including a high refractive index prism, a sensor chip, a light source having multiple wavelengths over a broad range of wavelengths, optical lenses, a photodetector, a data acquisition unit, and as defined herein. The sensor chip can include, for example, a thin layer of silicon and gold on one face of a transparent substrate and the prism adjacent to the opposite face of the transparent substrate. Such an arrangement provides variable penetration depths up to about 1.5 micrometers with a dynamic range for sensing index of refraction changes in a sample that are several times greater than that of a conventional SPR sensor. The disclosure provides methods for using the surface plasmon resonance sensor system for cell assay or chemical assay related applications.

Abstract: Systems and methods for sensing a surface plasmon resonance (SPR) biosensor using two or more wavelengths and with reduced chromatic aberration are disclosed. The system includes a beam-forming optical system that has chromatic aberration at the two or more wavelengths. A light source system provides respectively light of the two or more wavelengths, with light of each wavelength provided from a different distance from the beam-forming optical system. The different distances are selected to reduce or eliminate adverse effects of chromatic aberration on the formation of a focus spot on the SPR biosensor chip. An illumination system for illuminating a SPR biosensor using different light having different wavelengths is also disclosed.

Abstract: A surface plasmon resonance sensor system including a high refractive index prism, a sensor chip, a light source having multiple wavelengths over a broad range of wavelengths, optical lenses, a photodetector, a data acquisition unit, and as defined herein. The sensor chip can include, for example, a thin layer of silicon and gold on one face of a transparent substrate and the prism adjacent to the opposite face of the transparent substrate. Such an arrangement provides variable penetration depths up to about 1.5 micrometers with a dynamic range for sensing index of refraction changes in a sample that are several times greater than that of a conventional SPR sensor. The disclosure provides methods for using the surface plasmon resonance sensor system for cell assay or chemical assay related applications.

Abstract: A surface plasmon resonance sensor system including a high refractive index prism, a sensor chip, a light source having multiple wavelengths over a broad range of wavelengths, optical lenses, a photodetector, a data acquisition unit, and as defined herein. The sensor chip can include, for example, a thin layer of silicon and gold on one face of a transparent substrate and the prism adjacent to the opposite face of the transparent substrate. Such an arrangement provides variable penetration depths up to about 1.5 micrometers with a dynamic range for sensing index of refraction changes in a sample that are several times greater than that of a conventional SPR sensor. The disclosure provides methods for using the surface plasmon resonance sensor system for cell assay or chemical assay related applications.

Abstract: A surface plasmon resonance sensor system including a high refractive index prism, a sensor chip, a light source having multiple wavelengths over a broad range of wavelengths, optical lenses, a photodetector, a data acquisition unit, and as defined herein. The sensor chip can include, for example, a thin layer of silicon and gold on one face of a transparent substrate and the prism adjacent to the opposite face of the transparent substrate. Such an arrangement provides variable penetration depths up to about 1.5 micrometers with a dynamic range for sensing index of refraction changes in a sample that are several times greater than that of a conventional SPR sensor. The disclosure provides methods for using the surface plasmon resonance sensor system for cell assay or chemical assay related applications.