Patents by Inventor Norman John Lewis

Norman John Lewis has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 7351832
    Abstract: A process for preparing a compound of formula (I): or a tautomeric form thereof or a pharmaceutically acceptable salt thereof, or a pharmaceutically acceptable solvate thereof, wherein: A1 represents a substituted or unsubstituted aromatic heterocyclyl group; R1 represents a hydrogen atom, an alkyl group, an acyl group, an aralkyl group, wherein the aryl moiety may be substituted or unsubstituted, or a substituted or unsubstituted aryl group; A2 represents a benzene ring having in total up to five substituents; and n represents an integer in the range of from 2 to 6, which process comprises catalytically reducing a compound of formula (II): wherein A1, R1, A2 and n are as defined in relation to formula (I), characterised in that the reduction reaction is carried out using a hydrogen pressure above 20 psi; and thereafter if required forming a pharmaceutically acceptable salt and/or a pharmaceutically acceptable solvate of the compound of formula (I).
    Type: Grant
    Filed: October 18, 2006
    Date of Patent: April 1, 2008
    Assignee: SmithKline Beecham p.l.c.
    Inventors: Robert Gordon Giles, Norman John Lewis, John Kirby Quick
  • Patent number: 7091359
    Abstract: A process for preparing a compound of formula (I) or a tautomeric form thereof or a pharmaceutically acceptable salt thereof, wherein: A1 represents a substituted or unsubstituted aromatic heterocyclyl group; R1 represents a hydrogen atom, an alkyl group, an acyl group, an aralkyl group, wherein the aryl moiety may be substituted or unsubstituted, or a substituted or unsubstituted aryl group; A2 represents a benzene ring having in total up to five substituents; and n represents an integer in the range of from 2 to 6, which process comprises catalytically reducing a compound of formula (II): wherein A1, R1, A2 and n are as defined in relation to formula (I), characterized in that the reduction reaction is carried out using a hydrogen pressure above 20 psi; and thereafter if required forming a pharmaceutically acceptable salt and/or a pharmaceutically acceptable solvate of the compound of formula (I).
    Type: Grant
    Filed: November 4, 2002
    Date of Patent: August 15, 2006
    Assignee: SmithKline Beecham plc
    Inventors: Robert Gordon Giles, Norman John Lewis, John Kirby Quick
  • Patent number: 6632947
    Abstract: A process for preparing a compound of formula (I, I) or a tautomeric form thereof or a pharmaceutically acceptable salt thereof or a pharmaceutically acceptable solvate thereof, wherein: J represents O or S; T represents a substituted or unsubstituted aryl group and T1 is O or S; which process comprises reducing a compound of formula (II, II) or a tautomeric form thereof or a salt thereof or a solvate thereof, wherein T and T1 are as defined in relation to formula (I), with a complex hydride reducing agent or a source of a complex hydride reducing agent; and thereafter, as required, preparing a pharmaceutically acceptable salt or a pharmaceutically acceptable solvate of the compound of formula (I) or a tautomeric form thereof.
    Type: Grant
    Filed: November 8, 2001
    Date of Patent: October 14, 2003
    Assignee: SmithKline Beecham plc
    Inventors: Robert Gordon Giles, Norman John Lewis, Stephen Moore, Colin Ripley Pool, John Kirby Quick, Michael Urquhart
  • Publication number: 20030092742
    Abstract: A process for preparing a compound of formula (I) or a tautomeric form thereof or a pharmaceutically acceptable salt thereof, wherein: A1 represents a substituted or unsubstituted aromatic heterocyclyl group; R1 represents a hydrogen atom, an alkyl group, an acyl group, an aralkyl group, wherein the aryl moiety may be substituted or unsubstituted, or a substituted or unsubstituted aryl group; A2 represents a benzene ring having in total up to five substituents; and n represents an integer in the range of from 2 to 6, which process comprises catalytically reducing a compound of formula (II): wherein A1, R1, A2 and n are as defined in relation to formula (I), characterized in that the reduction reaction is carried out using a hydrogen pressure above 20 psi; and thereafter if required forming a pharmaceutically acceptable salt and/or a pharmaceutically acceptable solvate of the compound of formula (I).
    Type: Application
    Filed: November 4, 2002
    Publication date: May 15, 2003
    Applicant: SmithKline Beecham p.l.c.
    Inventors: Robert Gordon Giles, Norman John Lewis, Jonh Kirby Quick
  • Publication number: 20020120150
    Abstract: 1
    Type: Application
    Filed: February 26, 2002
    Publication date: August 29, 2002
    Applicant: SmithKline Beecham p.l.c.
    Inventors: Robert Gordon Giles, Norman John Lewis, John Kirby Quick
  • Publication number: 20020042519
    Abstract: A process for preparing a compound of formula (I, I) or a tautomeric form thereof or a pharmaceutically acceptable salt thereof or a pharmaceutically acceptable solvate thereof, wherein: J represents O or S; T represents a substituted or unsubstituted aryl group and T1 is O or S; which process comprises reducing a compound of formula (II, II) or a tautomeric form thereof or a salt thereof or a solvate thereof, wherein T and T1 are as defined in relation to formula (I), with a complex hydride reducing agent or a source of a complex hydride reducing agent; and thereafter, as required, preparing a pharmaceutically acceptable salt or a pharmaceutically acceptable solvate of the compound of formula (I) or a tautomeric form thereof.
    Type: Application
    Filed: November 8, 2001
    Publication date: April 11, 2002
    Applicant: SmithKline Beecham p.l.c.
    Inventors: Robert Gordon Giles, Norman John Lewis, Stephen Moore, Colin Ripley Pool, John Kirby Quick, Michael Urquhart
  • Patent number: 6069257
    Abstract: A process for preparing certain substituted benzopyran compounds of formula (I) ##STR1## is disclosed.
    Type: Grant
    Filed: July 6, 1999
    Date of Patent: May 30, 2000
    Assignee: SmithKline Beecham p.l.c.
    Inventors: Robert Gordon Giles, Norman John Lewis, Paul Oxley, John Kirby Quick
  • Patent number: 5777128
    Abstract: The present invention relates to a process for preparing compounds of structure (I), and the intermediate compound of formula (II).
    Type: Grant
    Filed: November 21, 1996
    Date of Patent: July 7, 1998
    Assignee: SmithKline Beecham p.l.c.
    Inventors: John David Hayler, Trevor John Grinter, Vance Novak, Norman John Lewis