Abstract: An endoscope can include a handle, an actuator coupled to the handle, and an elongated shaft coupled to the handle. The shaft can include a deflectable distal portion, an imaging assembly at a distal end of the shaft, a tube that defines a lumen, and a guide positioned within the lumen of the tube. The guide can include a first groove that cooperates with the tube to define a first lumen and a second groove that cooperates with the tube to define a second lumen through which communication lines associated with the imaging assembly pass. The endoscope can further include a steering wire coupled to the deflectable distal portion of the shaft, extending through the first lumen and coupled to the actuator, and coupled with the actuator such that actuation of the actuator causes the steering wire to deflect the distal portion of the shaft.