Abstract: Novel compositions comprising an antiandrogenic compound of the formula ##STR1## wherein R is COR.sub.1 wherein R.sub.1 is loweralkyl and a vehicle comprising a metabolism modulator and a polar organic solvent, and a method of controlling the membrane permeation and metabolism of the compound thereof are disclosed.

Abstract: A laminar structure for administering a chemical at a controlled release rate is disclosed. The structure comprises a backing member which acts as a boundary through which the chemical does not pass. Contacting at least a portion of the backing member is a chemical containing layer having therein a first chemical portion and a second chemical portion. The first and second chemical portions comprise a mixture of chemical in a first concentration transport mode and a second concentration transport mode. The mixture being in a ratio to give a desired chemical release rate from the chemical containing layer.

Abstract: A dosing unit for delivering a measured dosage includes a dosage well positioned on the inside wall of a spray tip or neck of a squeeze bottle, a fill trough for filling the well upon tilting of the bottle in any direction, and a spray tip for delivery of the dosage which includes an orifice and a flow tube extending from the bottom of the dosage well to the spray orifice. The well may be either molded into a spray tip or molded into the neck of the bottle or a molded insert that fits into the spray tip or bottle neck.

Abstract: A tablet breaking device comprises a base and a tablet splitting edge in the base. Means are provided for holding a tablet such that a portion of the tablet extends over the tablet splitting edge. The tablet holding means comprises an elongated opening tapering in depth and width. A moment of force sufficient to break the tablet can be created about the tablet splitting edge by applying a force substantially normal to a portion of the tablet extending over the tablet splitting edge.

Abstract: There is provided a device for measuring the force required to break a tablet, wherein the device comprises a tablet holding means comprising a base, a tablet splitting edge in the base and an area for holding a tablet in an inclined cantilevered position such that at least a portion of the cantilevered segment of the tablet extends over the tablet splitting edge. Means are provided for exerting a force substantially normal to a portion of the cantilevered segment of the tablet extending over the splitting edge to thereby create a moment of force about the tablet splitting edge sufficient to break the tablet. The device includes means for measuring the force required to break the tablet.