Patents by Inventor Norman L. Letvin

Norman L. Letvin has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • MYCOBACTERIAL VACCINE VECTORS AND METHODS OF USING THE SAME
    Publication number: 20140363465
    Abstract: Mycobacterium bovis BCG is a potent stimulator of the cellular immune response and has potential as a recombinant vaccine vector. Disclosed are BCG strains that generate greater MHC class I presentation of a transgenic protein, relative to the unmutated parental strain, and that improve a recipient's CD8+ T cell response against the transgenic protein following vaccination. The mycobacterial constructs and their respective t/ansposon mutant BCG strains exhibit increased immunogenicity that is several times greater than responses generated by the parental strain and other existing modified rBCG strains. Furthermore, upon introducing the SIV gag gene into these novel strains, we observed that these strains primed for increased CD8+ T cell responses in a heterologous prime/boost regimen, comparable to levels generated by plasmid DNA vaccines. Creation of a second generation rBCG vector that may be utilized as a vaccine vector for immunizing against a variety of pathogens.
    Type: Application
    Filed: April 4, 2012
    Publication date: December 11, 2014
    Applicant: Beth Israel Deaconess Medical Center, Inc.
    Inventors: Norman L Letvin, Michael W. Panas, Geoff Gillard
  • Mycobacteria expressing HIV-1 and malaria antigens
    Patent number: 7998471
    Abstract: Provided are recombinant mycobacteria expressing an HIV-1 antigen and a malarial antigen. Also provided are Mycobacterium smegmatis expressing an HIV-1 antigen. Further provided are vaccines capable of inducing an immune response in a mammal against HIV-1 and the malarial pathogen. Additionally provided are methods of inducing an immune response in a mammal against HIV-1 and a malarial pathogen. Also provided are methods of inducing an immune response in a mammal against HIV-1. The methods comprise infecting the mammal with any of the above-described mycobacteria.
    Type: Grant
    Filed: January 11, 2006
    Date of Patent: August 16, 2011
    Assignees: Albert Einstein College of Medicine of Yeshiva University, Beth Israel Deaconess Medical Center, Inc., Duke University
    Inventors: William R. Jacobs, Jr., Norman L. Letvin, Mark Cayabyab, Barton F. Haynes, Hua-Xin Liao, Jae-Sung Yu, Avi-Hai Hovav
  • Mycobacteria Expressing Hiv-1 and Malaria Antigens
    Publication number: 20080254061
    Abstract: Provided are recombinant mycobacteria expressing an HIV-1 antigen and a malarial antigen. Also provided are Mycobacterium smegmatis expressing an HIV-1 antigen. Further provided are vaccines capable of inducing an immune response in a mammal against HIV-1 and the malarial pathogen. Additionally provided are methods of inducing an immune response in a mammal against HIV-1 and a malarial pathogen. Also provided are methods of inducing an immune response in a mammal against HIV-1. The methods comprise infecting the mammal with any of the above-described mycobacteria.
    Type: Application
    Filed: January 11, 2006
    Publication date: October 16, 2008
    Inventors: William R. Jacobs, Norman L. Letvin, Mark Cayabyab, Barton F. Haynes, Hua-Xin Liao, Jae-Sung Yu, Avi-Hai Hovav