Patents by Inventor Norman S. Radin

Norman S. Radin has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Amino ceramide-like compounds and therapeutic methods of use
    Patent number: 6890949
    Abstract: Novel amino ceramide-like compounds (1) are provided which inhibit glucosyl ceramide (GlcCer) formation by inhibiting the enzyme GlcCer synthase, thereby lowering the level of glycosphingolipids. The compounds of the present invention have improved GlcCer synthase inhibition activity and are therefore highly useful in therapeutic methods for treating various conditions and diseases associated with altered glycosphingolipid levels.
    Type: Grant
    Filed: July 7, 2000
    Date of Patent: May 10, 2005
    Assignee: The Regents of the University of Michigan
    Inventors: James A. Shayman, Norman S. Radin
  • Amino ceramide-like compounds and therapeutic methods of use
    Patent number: 6569889
    Abstract: Novel amino ceramide-like compounds are provided which inhibit glucosyl ceramide (GlcCer) formation by inhibiting the enzyme GlcCer synthase, thereby lowering the level of glycosphingolipids. The compounds of the present invention have improved GlcCer synthase inhibition activity and are therefore highly useful in therapeutic methods for treating various conditions and diseases associated with altered glycosphingolipid levels.
    Type: Grant
    Filed: May 31, 2001
    Date of Patent: May 27, 2003
    Assignee: The Regents of the University of Michigan
    Inventors: James A. Shayman, Norman S. Radin
  • Amino ceramide-like compounds and therapeutic methods of use
    Publication number: 20030073680
    Abstract: The present invention provides amino ceramide-like compounds which inhibit glucosyl ceramide (GlyCer) formation by inhibiting the enzyme GlyCer synthase, thereby lowering the level of glycosphingolipids. The compounds of the present invention have improved GlcCer synthase inhibition activity and are therefore useful in therapeutic methods for treating various conditions and diseases associated with altered glycosphingolipid levels.
    Type: Application
    Filed: April 29, 2002
    Publication date: April 17, 2003
    Applicant: The Regents of The University of Michigan
    Inventors: James A. Shayman, Norman S. Radin
  • Amino ceramide - like compounds and therapeutic methods of use
    Publication number: 20020198240
    Abstract: Novel prodrugs of amino ceramide-like compounds are provided which inhibit glucosyl ceramide (GlcCer) formation by inhibiting the enzyme GlcCer synthase, thereby lowering the level of glycosphingolipids. The compounds of the present invention have improved GlcCer synthase inhibition activity and are therefore highly useful in therapeutic methods for treating various conditions and diseases associated with altered glycosphingolipid levels.
    Type: Application
    Filed: April 29, 2002
    Publication date: December 26, 2002
    Inventors: James A. Shayman, Norman S. Radin
  • Amino ceramide - like compounds and therapeutic methods of use
    Publication number: 20020156107
    Abstract: Novel prodrugs of amino ceramide-like compounds are provided which inhibit glucosyl ceramide (GlcCer) formation by inhibiting the enzyme GlcCer synthase, thereby lowering the level of glycosphingolipids. The compounds of the present invention have improved GlcCer synthase inhibition activity and are therefore highly useful in therapeutic methods for treating various conditions and diseases associated with altered glycosphingolipid levels.
    Type: Application
    Filed: January 10, 2002
    Publication date: October 24, 2002
    Inventors: James A. Shayman, Norman S. Radin
  • Amino ceramide - like compounds and therapeutic methods of use
    Publication number: 20010041735
    Abstract: Novel amino ceramide-like compounds are provided which inhibit glucosyl ceramide (GlcCer) formation by inhibiting the enzyme GlcCer synthase, thereby lowering the level of glycosphingolipids. The compounds of the present invention have improved GlcCer synthase inhibition activity and are therefore highly useful in therapeutic methods for treating various conditions and diseases associated with altered glycosphingolipid levels.
    Type: Application
    Filed: May 31, 2001
    Publication date: November 15, 2001
    Inventors: James A. Shayman, Norman S. Radin
  • Amino ceramide-like compounds and therapeutic methods of use
    Patent number: 6255336
    Abstract: Novel amino ceramide-like compounds are provided which inhibit glucosyl ceramide (GlcCer) formation by inhibiting the enzyme GlcCer synthase, thereby lowering the level of glycosphingolipids. The compounds of the present invention have improved GlcCer synthase inhibition activity and are therefore highly useful in therapeutic methods for treating various conditions and diseases associated with altered glycosphingolipid levels.
    Type: Grant
    Filed: July 9, 1999
    Date of Patent: July 3, 2001
    Assignee: The Regents of the University of Michigan
    Inventors: James A. Shayman, Norman S. Radin
  • Amino ceramide-like compounds and therapeutic methods of use
    Patent number: 6051598
    Abstract: Novel amino ceramide-like compounds are provided which inhibit glucosyl ceramide (GlcCer) formation by inhibiting the enzyme GlcCer synthase, thereby lowering the level of glycosphingolipids. The compounds of the present invention have improved GlcCer synthase inhibition activity and are therefore highly useful in therapeutic methods for treating various conditions and diseases associated with altered glycosphingolipid levels.
    Type: Grant
    Filed: June 26, 1997
    Date of Patent: April 18, 2000
    Assignee: The Regents of the University of Michigan
    Inventors: James A. Shayman, Norman S. Radin
  • Amino ceramide-like compounds and therapeutic methods of use
    Patent number: 6040332
    Abstract: Novel amino ceramide-like compounds are provided which inhibit glucosyl ceramide (GlcCer) formation by inhibiting the enzyme GlcCer synthase, thereby lowering the level of glycosphingolipids. The compounds of the present invention have improved GlcCer synthase inhibition activity and are therefore highly useful in therapeutic methods for treating various conditions and diseases associated with altered glycosphingolipid levels.
    Type: Grant
    Filed: June 26, 1997
    Date of Patent: March 21, 2000
    Assignee: The Regents of the University of Michigan
    Inventors: James A. Shayman, Norman S. Radin
  • Amino ceramide-like compounds and therapeutic methods of use
    Patent number: 6030995
    Abstract: Novel amino ceramide-like compounds are provided which inhibit glucosyl ceramide (GlcCer) formation by inhibiting the enzyme GlcCer synthase, thereby lowering the level of glycosphingolipids. The compounds of the present invention have improved GlcCer synthase inhibition activity and are therefore highly useful in therapeutic methods for treating various conditions and diseases associated with altered glycosphingolipid levels.
    Type: Grant
    Filed: October 29, 1998
    Date of Patent: February 29, 2000
    Assignee: The Regents of the University of Michigan
    Inventors: James A. Shayman, Norman S. Radin
  • Amino ceramide-like compounds and therapeutic methods of use
    Patent number: 5952370
    Abstract: Novel amino ceramide-like compounds are provided which inhibit glucosyl ceramide (GlcCer) formation by inhibiting the enzyme GlcCer synthase, thereby lowering the level of glycosphingolipids. The compounds of the present invention have improved GlcCer synthase inhibition activity and are therefore highly useful in therapeutic methods for treating various conditions and diseases associated with altered glycosphingolipid levels.
    Type: Grant
    Filed: June 26, 1997
    Date of Patent: September 14, 1999
    Assignee: The Regents of University of Michigan
    Inventors: James A. Shayman, Norman S. Radin
  • Amino ceramide-like compounds and therapeutic methods of use
    Patent number: 5945442
    Abstract: Novel amino ceramide-like compounds are provided which inhibit glucosyl ceramide (GlcCer) formation by inhibiting the enzyme GlcCer synthase, thereby lowering the level of glycosphingolipids. The compounds of the present invention have improved GlcCer sythase inhibition activity and are therefore highly useful in therapeutic methods for treating various conditions and diseases associated with altered glycosphingolipid levels.
    Type: Grant
    Filed: June 26, 1997
    Date of Patent: August 31, 1999
    Assignee: The Regents of The University of Michigan
    Inventors: James A. Shayman, Norman S. Radin
  • Amino ceramide--like compounds and therapeutic methods of use
    Patent number: 5916911
    Abstract: Novel amino compounds are provided which inhibit glucosyl ceramide (GlcCer) formation by inhibiting the enzyme GlcCer synthase, thereby lowering the level of glycosphingolipids. The compounds of the present invention have improved GlcCer synthase inhibition activity and are therefore highly useful in therapeutic methods for treating various conditions and diseases associated with altered glycosphingolipid levels.
    Type: Grant
    Filed: September 5, 1996
    Date of Patent: June 29, 1999
    Assignee: The Regents Of The University Of Michigan
    Inventors: James A. Shayman, Norman S. Radin
  • Treatment of diabetic nephropathy
    Patent number: 5302609
    Abstract: The present invention is a novel method for the treatment of renal hypertrophy and hyperplasia associated with diabetic nephropathy. The method of the present invention generally comprises the administration to the diabetic patient of a compound which inhibits glycosphingolipid synthesis, more particularly, an inhibitor of GlcCer synthase or 3-ketodihydrosphingosine synthase.
    Type: Grant
    Filed: December 16, 1992
    Date of Patent: April 12, 1994
    Assignee: The Regents of the University of Michigan
    Inventors: James A. Shayman, Norman S. Radin
  • Method of chemotherapy using 1-phenyl-2-decanoylamino-3-morpholino-1-propanol
    Patent number: 5041441
    Abstract: An inhibitor of glycosphingolipid metabolism is used as a chemotherapeutic agent against cancer or to treat other conditions caused by cell proliferation sensitive glycosphingolipid metabolism inhibition. A preferred inhibitor is 1-phenyl-2-acylamino-3-morpholino-1-propanol.
    Type: Grant
    Filed: April 4, 1988
    Date of Patent: August 20, 1991
    Assignee: The Regents of the University of Michigan
    Inventors: Norman S. Radin, Jin-ichi Inokuchi
  • Process for waste nitrogen removal
    Patent number: 4284647
    Abstract: A process for controlling waste nitrogen accumulation diseases in humans which comprises administering an effective amount of at least one compound selected from the group consisting of benzoic acid, phenylacetic acid and the non-toxic, pharmaceutically-acceptable salts of the acids to a human suffering from waste nitrogen accumulation.
    Type: Grant
    Filed: March 31, 1980
    Date of Patent: August 18, 1981
    Assignee: The Johns Hopkins University
    Inventors: Saul W. Brusilow, Mark L. Batshaw, Norman S. Radin