Patents by Inventor Norman Schechter

Norman Schechter has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Therapeutic agents
    Patent number: 9540336
    Abstract: The present invention includes a method of treating or preventing a disease or disorder such as a mycobacterial infection, a Gram-positive bacterium infection, a yeast infection, an inflammatory condition, an auto-immune disorder and/or a proliferative disorder in a subject in need thereof. The method comprises administering to the subject a therapeutically effective amount of at least one compound of the invention, which includes clofazimine derivatives.
    Type: Grant
    Filed: December 21, 2012
    Date of Patent: January 10, 2017
    Assignee: The Trustees of the University of Pennsylvania
    Inventors: Harvey Rubin, Takahiro Yano, Sacha Kassovska-Bratinova, Norman Schechter, Jiah Shin Teh, Jeffrey Winkler
  • NOVEL THERAPEUTIC AGENTS
    Publication number: 20140371228
    Abstract: The present invention includes a method of treating or preventing a disease or disorder such as a mycobacterial infection, a Gram-positive bacterium infection, a yeast infection, an inflammatory condition, an auto-immune disorder and/or a proliferative disorder in a subject in need thereof. The method comprises administering to the subject a therapeutically effective amount of at least one compound of the invention, which includes clofazimine derivatives.
    Type: Application
    Filed: December 21, 2012
    Publication date: December 18, 2014
    Inventors: Harvey Rubin, Takahiro Yano, Sacha Kassovska-Bratinova, Norman Schechter, Jiah Shin Teh, Jeffrey Winkler
  • Methods for detecting genetic mutations resulting in protease inhibitor insufficiencies
    Patent number: 5827662
    Abstract: A method of producing a recombinant serine protease inhibitor capable of effectively modulating serine protease activity is provided. Compositions capable of modulating serine protease activity and use of such compositions to regulate inflammatory processes in cells are also provided.
    Type: Grant
    Filed: December 18, 1996
    Date of Patent: October 27, 1998
    Assignee: The Trustees of the University of Pennsylvania
    Inventors: Harvey Rubin, Barry Cooperman, Norman Schechter, Michael Plotnick, Zhi Mei Wang
  • .alpha.-1-antichymotrypsin analogues having chymase inhibiting activity
    Patent number: 5723316
    Abstract: The invention provides analogues of .alpha.-1-antichymotrypsin having amino acid substitutions at position 358. .alpha.-1-antichymotrypsin analogues having amino acid substitutions at positions 356-361 and analogues having amino acid substitutions at positions 356-361 wherein the amino acid at position 358 is substituted are also within the scope of the invention. These analogues exhibit chymase inhibitory activity. Also provided are novel .alpha.-1-antichymotrypsins having an N-terminal extension of methionine-alanine-serine or alanine-serine. Expression vectors for the production of .alpha.-1-antichymotrypsins are also provided. The present invention also provides host cells and cell cultures capable of expressing analogues of .alpha.-1-antichymotrypsin, as well as protein preparations from the host cells. Methods of producing and using the analogues of .alpha.-1-antichymotrypsin to inhibit chymase activity are also provided.
    Type: Grant
    Filed: March 31, 1994
    Date of Patent: March 3, 1998
    Assignee: Trustees of the University of Pennsylvania
    Inventors: Barry S. Cooperman, Harvey Rubin, Norman Schechter, Zhi Mei Wang
  • .alpha.-1-antichymotrypsin analogues having elastase inhibitory activity
    Patent number: 5674708
    Abstract: The present invention provides an analogue of human .alpha.-1-antichymotrypsin wherein the amino acid at position 358 is selected from the group consisting of isoleucine, valine, alanine, aspattic acid, threonine, and glutamic acid.
    Type: Grant
    Filed: March 31, 1994
    Date of Patent: October 7, 1997
    Assignee: Trustees of the University of Pennsylvania
    Inventors: Barry S. Cooperman, Harvey Rubin, Norman Schechter, Zhi Mei Wang
  • Methods of producing effective recombinant serine protease inhibitors and uses of these inhibitors
    Patent number: 5612194
    Abstract: A method of producing a recombinant serine protease inhibitor capable of effectively modulating serine protease activity is provided. Compositions capable of modulating serine protease activity and use of such compositions to regulate inflammatory processes in cells are also provided.
    Type: Grant
    Filed: July 19, 1994
    Date of Patent: March 18, 1997
    Assignee: Trustees of the University of Pennsylvania
    Inventors: Harvey Rubin, Barry Cooperman, Norman Schechter, Michael Plotnick, Zhi M. Wang
  • .alpha.-1-antichymotrypsin, analogues and methods of production
    Patent number: 5367064
    Abstract: The invention provides .alpha.-1-antichymotrypsin and protein preparations comprising human .alpha.-1-antichymotrypsin produced by E. coli cells transformed with a DNA sequence encoding human .alpha.-1-antichymotrypsin. The invention also provides methods for producing .alpha.-1-antichymotrypsin. The invention further provides analogues of .alpha.-1-antichymotrypsin that exhibit antichymotrypsin, anti-trypsin and anti-thrombin activity and methods of producing the analogues.
    Type: Grant
    Filed: January 15, 1993
    Date of Patent: November 22, 1994
    Assignee: The Trustees of the University of Pennylsvania
    Inventors: Harvey Rubin, Zhi M. Wang, Barry S. Cooperman, Norman Schechter