Abstract: A driving system for driving at least one auger of a snow removing device comprising at least one at least one self-adjusting chain tensioner. A first portion of the driving system is positioned within an auger housing and a second portion of the driving system is positioned outside the auger housing. The roller chain is adapted to move across a third opening provided in the auger housing. The first portion is covered by a front guard to prevent snow or debris contained in the auger housing to contact said first portion. The front guard is provided with an opening adapted to surround a portion of a shaft element of the auger with a play between periphery of the opening and the periphery of a corresponding portion the shaft element.

Abstract: The present invention provides novel compounds compositions and methods for (i) treating or preventing inflammation; and (ii) preventing or reducing hyperactivation of innate immune response, by inhibiting NRP1-dependent cell-signaling. Also provided are compounds, composition, and methods of specifically inhibiting SEMA3A-mediated cell signaling.

Abstract: The present invention provides novel compounds compositions and methods for (i) treating or preventing inflammation; and (ii) preventing or reducing hyperactivation of innate immune response, by inhibiting NRP1-dependent cell-signaling. Also provided are compounds, composition, and methods of specifically inhibiting SEMA3A-mediated cell signaling.

Abstract: A driving system for driving at least one auger of a snow removing device comprising at least one at least one self-adjusting chain tensioner. A first portion of the driving system is positioned within an auger housing and a second portion of the driving system is positioned outside the auger housing. The roller chain is adapted to move across a third opening provided in the auger housing. The first portion is covered by a front guard to prevent snow or debris contained in the auger housing to contact said first portion. The front guard is provided with an opening adapted to surround a portion of a shaft element of the auger with a play between periphery of the opening and the periphery of a corresponding portion the shaft element.

Abstract: Described herein are compositions and methods for modulating cellular senescence of a cell or induction of the senescence-associated secretory phenotype (SASP) in a cell. The methods generally comprise modulating the level or activity of IRE1a as a mean to control cellular senescence and induction of the SASP. Also described are methods for treating and preventing ocular vascular diseases comprising contacting cells in an eye of a subject with a biguanide compound and ophthalmic compositions comprising a biguanide compound.

Abstract: A driving system for driving at least one auger of a snow removing device comprising at least one at least one self-adjusting chain tensioner. A first portion of the driving system is positioned within an auger housing and a second portion of the driving system is positioned outside the auger housing. The roller chain is adapted to move across a third opening provided in the auger housing. The first portion is covered by a front guard to prevent snow or debris contained in the auger housing to contact said first portion. The front guard is provided with an opening adapted to surround a portion of a shaft element of the auger with a play between periphery of the opening and the periphery of a corresponding portion the shaft element.

Abstract: The present invention provides novel compounds compositions and methods for (i) treating or preventing inflammation; and (ii) preventing or reducing hyperactivation of innate immune response, by inhibiting NRP1-dependent cell-signaling. Also provided are compounds, composition, and methods of specifically inhibiting SEMA3A-mediated cell signaling.

Abstract: A driving system for driving at least one auger of a snow removing device comprising at least one at least one self-adjusting chain tensioner. A first portion of the driving system is positioned within an auger housing and a second portion of the driving system is positioned outside the auger housing. The roller chain is adapted to move across a third opening provided in the auger housing. The first portion is covered by a front guard to prevent snow or debris contained in the auger housing to contact said first portion. The front guard is provided with an opening adapted to surround a portion of a shaft element of the auger with a play between periphery of the opening and the periphery of a corresponding portion the shaft element.

Abstract: The present invention provides novel compounds compositions and methods for (i) treating or preventing inflammation; and (ii) preventing or reducing hyperactivation of innate immune response, by inhibiting NRP1-dependent cell-signaling. Also provided are compounds, composition, and methods of specifically inhibiting SEMA3A-mediated cell signaling.

Abstract: A driving system for driving at least one auger of a snow removing device comprising at least one at least one self-adjusting chain tensioner. A first portion of the driving system is positioned within an auger housing and a second portion of the driving system is positioned outside the auger housing. The roller chain is adapted to move across a third opening provided in the auger housing. The first portion is covered by a front guard to prevent snow or debris contained in the auger housing to contact said first portion. The front guard is provided with an opening adapted to surround a portion of a shaft element of the auger with a play between periphery of the opening and the periphery of a corresponding portion the shaft element.

Abstract: The present invention provides novel compounds compositions and methods for (i) treating or preventing inflammation; and (ii) preventing or reducing hyperactivation of innate immune response, by inhibiting NRP1-dependent cell-signaling. Also provided are compounds, composition, and methods of specifically inhibiting SEMA3A-mediated cell signaling.

Abstract: Described herein are compositions and methods for modulating cellular senescence of a cell or induction of the senescence-associated secretory phenotype (SASP) in a cell. The methods generally comprise modulating the level or activity of IRE1a as a mean to control cellular senescence and induction of the SASP. Also described are methods for treating and preventing ocular vascular diseases comprising contacting cells in an eye of a subject with a biguanide compound and ophthalmic compositions comprising a biguanide compound.

Abstract: The present invention provides novel compounds compositions and methods for (i) treating or preventing inflammation; and (ii) preventing or reducing hyperactivation of innate immune response, by inhibiting NRP1-dependent cell-signaling. Also provided are compounds, composition, and methods of specifically inhibiting SEMA3A-mediated cell signaling.

Abstract: A driving system for driving at least one auger of a snow removing device comprising at least one at least one self-adjusting chain tensioner. A first portion of the driving system is positioned within an auger housing and a second portion of the driving system is positioned outside the auger housing. The roller chain is adapted to move across a third opening provided in the auger housing. The first portion is covered by a front guard to prevent snow or debris contained in the auger housing to contact said first portion. The front guard is provided with an opening adapted to surround a portion of a shaft element of the auger with a play between periphery of the opening and the periphery of a corresponding portion the shaft element.

Abstract: The present invention provides novel compounds compositions and methods for (i) treating or preventing inflammation; and (ii) preventing or reducing hyperactivation of innate immune response, by inhibiting NRP1-dependent cell-signaling. Also provided are compounds, composition, and methods of specifically inhibiting SEMA3A-mediated cell signaling.