Patents by Inventor Normand Hebert

Normand Hebert has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Monomeric diols, phosphate linked oligomers formed therefrom and processes for preparing
    Publication number: 20030065146
    Abstract: Novel ethylene glycol compounds bearing various functional groups are used to prepare oligomeric structures. The ethylene glycol monomers can be joined via standard phosphate linkages including phosphodiester and phosphorothioate linkages. Useful functional groups include nucleobases as well as polar groups, hydrophobic groups, ionic groups, aromatic groups and/or groups that participate in hydrogen-bonding.
    Type: Application
    Filed: June 3, 2002
    Publication date: April 3, 2003
    Inventors: Phillip D. Cook, Oscar L. Acevedo, Peter W. Davis, David J. Ecker, Normand Hebert
  • Triazole compounds and methods of making same
    Patent number: 6362342
    Abstract: The present invention relates to novel triazole compounds of the following formula: wherein R1 to R5 have the meanings provided herein. The invention further relates to combinatorial libraries containing two or more such compounds, as well as methods of preparing triazole compounds.
    Type: Grant
    Filed: June 29, 1999
    Date of Patent: March 26, 2002
    Assignee: Lion Bioscience AG
    Inventors: Ming Qi, R. Normand Hebert, Alan R. Katritzky
  • Chemical synthesis apparatus employing a droplet generator
    Publication number: 20010028866
    Abstract: Chemical reaction apparatus, materials and methods are provided for the automatable, efficient synthesis of chemical species and libraries. In accordance with preferred embodiments, chemical droplet generation and direction techniques are employed to prepare oligomers and libraries of chemical species. Reaction assemblies adapted for efficient synthetic employment and for improved collection are also disclosed.
    Type: Application
    Filed: May 23, 2001
    Publication date: October 11, 2001
    Applicant: ISIS Pharmaceuticals, Inc.
    Inventors: David J. Ecker, Oscar Acevedo, Normand Hebert, Peter W. Davis, Jacqueline R. Wyatt, John S. Kiely
  • Chemical synthesis apparatus employing a droplet generator
    Patent number: 6277334
    Abstract: Chemical reaction apparatus, materials and methods are provided for the automatable, efficient synthesis of chemical species and libraries. In accordance with preferred embodiments, chemical droplet generation and direction techniques are employed to prepare oligomers and libraries of chemical species. Reaction assemblies adapted for efficient synthetic employment and for improved collection are also disclosed.
    Type: Grant
    Filed: May 18, 1999
    Date of Patent: August 21, 2001
    Assignee: ISIS Pharmaceuticals, Inc.
    Inventors: David J. Ecker, Oscar Acevedo, Normand Hebert, Peter W. Davis, Jacqueline R. Wyatt, John S. Kiely
  • Methods and compounds for tracking the biodistribution of macromolecule-carrier combinations
    Patent number: 6225293
    Abstract: The present invention provides improved methods for tracking the biodistribution of macromolecules and carriers in cells. In accordance with one embodiment, oligonucleotides and lipid carriers are differentially fluorescently labeled and coadministered to the cells. Useful compounds and synthetic methods are also provided.
    Type: Grant
    Filed: September 2, 1998
    Date of Patent: May 1, 2001
    Assignee: Isis Pharmaceuticals, Inc.
    Inventors: Clarence Frank Bennett, Muthiah Manoharan, Normand Hebert, Balkrishen Bhat
  • Combinatorial libraries having aminodiol monomer subunits
    Patent number: 6184389
    Abstract: Combinatorial libraries are constructed to include aminodiol monomer subunits connected by phosphodiester, phosphorothioate, or phosphoramidate linking moieties. Combinatorial libraries of the invention feature a plurality of functional groups attached to backbone and phosphoramidate combinatorial sites.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: February 6, 2001
    Assignee: ISIS Pharmaceuticals, Inc.
    Inventor: Normand Hebert
  • Chemical reaction apparatus for performing multiple reaction on a surface and collecting the product
    Patent number: 5925732
    Abstract: Chemical reaction apparatus, materials and methods are provided for the automatable, efficient synthesis of chemical species and libraries. In accordance with preferred embodiments, chemical droplet generation and direction techniques are employed to prepare oligomers and libraries of chemical species. Reaction assemblies adapted for efficient synthetic employment and for improved collection are also disclosed.
    Type: Grant
    Filed: January 2, 1997
    Date of Patent: July 20, 1999
    Assignee: ISIS Pharmaceuticals, Inc.
    Inventors: David J. Ecker, Oscar Acevedo, Normand Hebert, Peter W. Davis, Jacqueline R. Wyatt, John S. Kiely
  • Phosphate linked oligomers
    Patent number: 5886177
    Abstract: Novel ethylene glycol compounds bearing various functional groups are used to prepare oligomeric structures. The ethylene glycol monomers can be joined via standard phosphate linkages including phosphorothioate, phosphodiester, and phosphoramidate linkages. Useful functional groups include nucleobases as well as polar groups, hydrophobic groups, ionic groups, aromatic groups and/or groups that participate in hydrogen-bonding.
    Type: Grant
    Filed: August 8, 1996
    Date of Patent: March 23, 1999
    Assignee: ISIS Pharmaceuticals, Inc.
    Inventors: Phillip Dan Cook, Oscar L. Acevedo, Peter W. Davis, David J. Ecker, Normand Hebert
  • Phosphoramidate and phosphorothiomidate oligomeric compounds
    Patent number: 5717083
    Abstract: Compounds are provided having structure (I), wherein the L groups are backbone segments, the Y and T groups are functional groups for interacting with target molecules of interest, the X groups are oxygen or sulfur and the E groups are H, conjugate groups or intermediate groups used during the synthesis of the compounds and wherein the compounds are prepared using H phosphonate type chemistry wherein the functional groups are added during an oxidation step or during a coupling step.
    Type: Grant
    Filed: August 19, 1996
    Date of Patent: February 10, 1998
    Assignee: ISIS Pharmaceuticals, Inc.
    Inventors: Phillip Dan Cook, Oscar Acevedo, Normand Hebert
  • Pyrrolidine-containing monomers and oligomers
    Patent number: 5714606
    Abstract: The invention relates to pyrrolidine monomeric units and to oligomers which are joined via phosphate linkages, including phosphorothioate, phosphodiester and phosphoramidate linkages.
    Type: Grant
    Filed: August 15, 1996
    Date of Patent: February 3, 1998
    Assignee: ISIS Pharmaceuticals, Inc.
    Inventors: Oscar L. Acevedo, Normand Hebert
  • Phosphoramidate and phosphorothioamidate oligomeric compounds
    Patent number: 5637684
    Abstract: Compounds are provided having the structure: ##STR1## wherein the L groups are spanner or linker units, the Y and T group are functional groups for interacting with target molecules of interest, the X groups are oxygen or sulfur and the E groups are H, conjugate groups or intermediate groups used during the synthesis of the compounds are prepared using H phosphonate type chemistry wherein the functional groups are added during an oxidization step.
    Type: Grant
    Filed: February 23, 1994
    Date of Patent: June 10, 1997
    Assignee: ISIS Pharmaceuticals, Inc.
    Inventors: Phillip D. Cook, Oscar Acevedo, Normand Hebert
  • Pyrrolidine-containing monomers and oligomers
    Patent number: 5519134
    Abstract: Novel pyrrolidine monomers bearing various functional groups are used to prepare oligomeric structures. The pyrrolidine monomers can be joined via standard phosphate linkages including phosphodiester and phosphorothioate linkages. Useful functional groups include nucleobases as well as polar groups, hydrophobic groups, ionic groups, aromatic groups and/or groups that participate in hydrogen-bonding.
    Type: Grant
    Filed: January 11, 1994
    Date of Patent: May 21, 1996
    Assignee: Isis Pharmaceuticals, Inc.
    Inventors: Oscar L. Acevedo, Normand Hebert