Abstract: In some examples, a load adapter may include a body including an elongated shaft that includes an inlet passage that is in fluid communication with at least one outlet hole. The at least one outlet hole may be dimensioned to provide an opening area that is between approximately 5% to approximately 90% of a face of the body.

Abstract: A chromatography column includes a first flow distributor, a second flow distributor, and a media chamber having an inlet and an outlet. The second flow distributor is different from the first flow distributor. The first flow distributor is secured to the inlet of the media chamber and the second flow distributor is secured to the outlet of the media chamber.

Abstract: A chromatography column includes a tube, a fit assembly, a first end fitting and a second end fitting. An annular protrusion extends from an end face of the tube to a protrusion height and circumscribes a chamber in fluid communication with the axial bore. Both the chamber and the bore may be filled with a packing material. The fit assembly includes a deformable ring having a yield strength less than a yield strength of the annular protrusion. The ring contacts the annular protrusion such that the frit assembly provides a chamber boundary that retains the packing material. The first end fitting is securely fastened to the tube such that the ring is axially compressed and deformed around the annular protrusion, the chamber height is less than the protrusion height, and the packing material is compressed.

Abstract: A chromatography column includes a tube, a fit assembly, a first end fitting and a second end fitting. An annular protrusion extends from an end face of the tube to a protrusion height and circumscribes a chamber in fluid communication with the axial bore. Both the chamber and the bore may be filled with a packing material. The fit assembly includes a deformable ring having a yield strength less than a yield strength of the annular protrusion. The ring contacts the annular protrusion such that the frit assembly provides a chamber boundary that retains the packing material. The first end fitting is securely fastened to the tube such that the ring is axially compressed and deformed around the annular protrusion, the chamber height is less than the protrusion height, and the packing material is compressed.